The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Alternative splicing and the evolution of phenotypic novelty
Open accessAbstract
Alternative splicing, a mechanism of post-transcriptional RNA processing whereby a single gene can encode multiple distinct transcripts, has been proposed to underlie morphological innovations in multicellular organisms. Genes with developmental functions are enriched for alternative splicing events, suggestive of a contribution of alternative splicing to developmental programmes. The role of alternative splicing as a source of transcript diversification has previously been compared to that of gene duplication, with the relationship between the two extensively explored. Alternative splicing is reduced following gene duplication with the retention of duplicate copies higher for genes which were alternatively spliced prior to duplication. Furthermore, and unlike the case for overall gene number, the proportion of alternatively spliced genes has also increased in line with the evolutionary diversification of cell types, suggesting alternative splicing may contribute to the complexity of developmental programmes. Together these observations suggest a prominent role for alternative splicing as a source of functional innovation. However, it is unknown whether the proliferation of alternative splicing events indeed reflects a functional expansion of the transcriptome or instead results from weaker selection acting on larger species, which tend to have a higher number of cell types and lower population sizes. This article is part of the themed issue ‘Evo-devo in the genomics era, and the origins of morphological diversity’.
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Cites
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“binding – flexible sensors are more adaptable than rigid ones [74, 75] – supporting an association of alternative splicing 96”
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Cited by
Alternative splicing as a source of phenotypic diversity
Wright, C. J., Smith, C. W. J., & Jiggins, C. D. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00514-4 · Cited by 454
Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
Ping, L., Kundinger, S. R., Duong, D. M., Yin, L., Gearing, M., Lah, J. J., Levey, A. I., & Seyfried, N. T. (2020) · Scientific Data · doi:10.1038/s41597-020-00650-8 · Cited by 127
Shinde, S. S., Sharma, S., Teekas, L., Sharma, A., & Vijay, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-04077-y · Cited by 10
Drug screening at single-organoid resolution via bioprinting and interferometry
Tebon, P. J., Wang, B., Markowitz, A. L., Davarifar, A., Krawczuk, P., Murray, G., Nguyen, H. T. L., Tavanaie, N., Nguyen, T. L., Boutros, P. C., et al. (2021) · doi:10.1101/2021.10.03.462896 · Cited by 155
Metadata
- Authors
- Bush, S. J., Chen, L., Tovar-Corona, J. M., & Urrutia, A. O.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2017-02-05
- Volume
- 372
- Issue
- 1713
- Pages
- 20150474
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2563339645
- Cited by
- 193
- References
- 16
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
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