Function of alternative splicing

AUGUSTUS: ab initio prediction of alternative transcripts

Stanke, M., Keller, O., Gunduz, I., Hayes, A., Waack, S., & Morgenstern, B. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl200 · Cited by 2,829 · see citing works

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · see citing works

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665 · see citing works

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

Tripathi, V., Ellis, J. D., Shen, Z., Song, D. Y., Pan, Q., Watt, A. T., Freier, S. M., Bennett, C. F., Sharma, A., Bubulya, P. A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.011 · Cited by 2,223 · see citing works

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

Berget, S. M., Moore, C. L., & Sharp, P. A. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3171 · Cited by 1,424 · see citing works

The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing

Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works

Function of alternative splicing

Stamm, S., Ben‐Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., & Soreq, H. (2004) · Gene · doi:10.1016/j.gene.2004.10.022 · Cited by 1,373 · see citing works

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature · doi:10.1038/nature07488 · Cited by 1,352 · see citing works

Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources

Stanke, M., Schöffmann, O., Morgenstern, B., & Waack, S. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-62 · Cited by 1,304 · see citing works

Understanding alternative splicing: towards a cellular code

Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299 · see citing works

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

Sultan, M., Schulz, M. H., Richard, H., Magen, A., Klingenhoff, A., Scherf, M., Seifert, M., Borodina, T., Soldatov, A., Parkhomchuk, D., et al. (2008) · Science · doi:10.1126/science.1160342 · Cited by 1,293 · see citing works

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284 · see citing works

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

Chow, L. T., Gelinas, R. E., Broker, T. R., & Roberts, R. J. (1977) · Cell · doi:10.1016/0092-8674(77)90180-5 · Cited by 1,234 · see citing works

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179 · see citing works

RNA and Disease

Cooper, T. A., Wan, L., & Dreyfuss, G. (2009) · Cell · doi:10.1016/j.cell.2009.02.011 · Cited by 1,160 · see citing works

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

König, J., Zarnack, K., Rot, G., Curk, T., Kayikci, M., Zupan, B., Turner, D. J., Luscombe, N. M., & Ule, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1838 · Cited by 1,126 · see citing works

CLIP Identifies Nova-Regulated RNA Networks in the Brain

Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120 · see citing works

Regulation of Alternative Splicing by Histone Modifications

Luco, R. F., Pan, Q., Tominaga, K., Blencowe, B. J., Pereira‐Smith, O. M., & Misteli, T. (2010) · Science · doi:10.1126/science.1184208 · Cited by 1,099 · see citing works

Exon Recognition in Vertebrate Splicing

Berget, S. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2411 · Cited by 1,090 · see citing works

Alternative splicing and evolution: diversification, exon definition and function

Keren, H., Lev-Maor, G., & Ast, G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2776 · Cited by 1,082 · see citing works

Splicing in disease: disruption of the splicing code and the decoding machinery

Wang, G., & Cooper, T. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2164 · Cited by 1,040 · see citing works

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,035 · see citing works

Splicing of a Novel <i>Androgen Receptor</i> Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., & Tindall, D. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0594 · Cited by 834 · see citing works

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedPreprint

David, C. J., & Manley, J. L. (2010) · Genes & Development · doi:10.1101/gad.1973010 · Cited by 815 · see citing works

Acid-Mediated Tumor Invasion: a Multidisciplinary Study

Gatenby, R. A., Gawlinski, E. T., Gmitro, A. F., Kaylor, B., & Gillies, R. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4193 · Cited by 771 · see citing works

Structure and evolution of transcriptional regulatory networks

Babu, M. M., Luscombe, N. M., Aravind, L., Gerstein, M., & Teichmann, S. A. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.05.004 · Cited by 764 · see citing works

The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers

Lyko, F., Foret, S., Kucharski, R., Wolf, S., Falckenhayn, C., & Maleszka, R. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000506 · Cited by 727 · see citing works

The <i>Evf-2</i> noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator

Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., & Kohtz, J. D. (2006) · Genes &amp; Development · doi:10.1101/gad.1416106 · Cited by 712 · see citing works

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

Frías, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W. A., Sculley, T. B., Carr, S. A., & Sabatini, D. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.001 · Cited by 690 · see citing works

Differential chromatin marking of introns and expressed exons by H3K36me3

Kolasinska-Zwierz, P., Down, T. A., Latorre, I. J., Liu, T., Liu, X. S., & Ahringer, J. (2009) · Nature Genetics · doi:10.1038/ng.322 · Cited by 671 · see citing works

Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets

Denis, M. M., Tolley, N. D., Bunting, M., Schwertz, H., Jiang, H., Lindemann, S., Yost, C. C., Rubner, F. J., Albertine, K. H., Swoboda, K. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.015 · Cited by 652 · see citing works

AceView: a comprehensive cDNA-supported gene and transcripts annotation

Thierry-Mieg, D., & Thierry-Mieg, J. (2006) · Genome Biology · doi:10.1186/gb-2006-7-s1-s12 · Cited by 629 · see citing works

Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis

Johnson, M. B., Kawasawa, Y. I., Mason, C. E., Krsnik, Ž., Coppola, G., Bogdanović, D., Geschwind, D. H., Mane, S. M., State, M. W., & Šestan, N. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.027 · Cited by 603 · see citing works

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

Yeo, G. W., Coufal, N. G., Liang, T. Y., Peng, G. E., Fu, X.-D., & Gage, F. H. (2009) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1545 · Cited by 572 · see citing works

Different levels of alternative splicing among eukaryotes

Kim, E., Magen, A., & Ast, G. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl924 · Cited by 545 · see citing works

Alternative splicing and disease

Tazi, J., Bakkour, N., & Stamm, S. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.017 · Cited by 541 · see citing works

Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms

Romero, P. R., Zaidi, S., Fang, Y. Y., Uversky, V. N., Radivojac, P., Oldfield, C. J., Cortese, M. S., Sickmeier, M., LeGall, T., Obradovic, Z., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507916103 · Cited by 480 · see citing works

RNA-MEDIATED NEUROMUSCULAR DISORDERS

Ranum, L. P. W., & Cooper, T. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113014 · Cited by 472 · see citing works

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

Xue, Y., Zhou, Y., Wu, T., Zhu, T., Ji, X., Kwon, Y.-S., Zhang, C., Yeo, G., Black, D. L., Sun, H., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.003 · Cited by 469 · see citing works

Nucleosome positioning as a determinant of exon recognition

Tilgner, H., Nikolaou, C., Althammer, S., Sammeth, M., Beato, M., Valcárcel, J., & Guigó, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1658 · Cited by 446 · see citing works

The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons

Lev-Maor, G., Sorek, R., Shomron, N., & Ast, G. (2003) · Science · doi:10.1126/science.1082588 · Cited by 435 · see citing works

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Cheah, M. T., Wachter, A., Sudarsan, N., & Breaker, R. R. (2007) · Nature · doi:10.1038/nature05769 · Cited by 430 · see citing works

Influence of RNA Secondary Structure on the Pre-mRNA Splicing Process

Buratti, E., & Baralle, F. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10505-10514.2004 · Cited by 425 · see citing works

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

Clower, C. V., Chatterjee, D., Wang, Z., Cantley, L. C., Vander Heiden, M. G., & Krainer, A. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914845107 · Cited by 424 · see citing works

Intron—exon structures of eukaryotic model organisms

Long, M., & Deutsch, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3219 · Cited by 417 · see citing works

The pathobiology of splicing

Ward, A. J., & Cooper, T. A. (2009) · The Journal of Pathology · doi:10.1002/path.2649 · Cited by 415 · see citing works

Cell Motility Is Controlled by SF2/ASF through Alternative Splicing of the Ron Protooncogene

Ghigna, C., Giordano, S., Shen, H., Benvenuto, F., Castiglioni, F., Comoglio, P. M., Green, M. R., Riva, S., & Biamonti, G. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.026 · Cited by 389 · see citing works

An ESRP‐regulated splicing programme is abrogated during the epithelial–mesenchymal transition

Warzecha, C. C., Jiang, P., Amirikian, K., Dittmar, K. A., Lu, H., Shen, S., Guo, W., Xing, Y., & Carstens, R. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.195 · Cited by 383 · see citing works

ASTALAVISTA: dynamic and flexible analysis of alternative splicing events in custom gene datasets

Foissac, S., & Sammeth, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm311 · Cited by 377 · see citing works

Neuronal regulation of alternative pre-mRNA splicing

Li, Q., Lee, J.-A., & Black, D. L. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2237 · Cited by 376 · see citing works

Polypyrimidine Tract Binding Protein Antagonizes Exon Definition

Wagner, E. J., & García-Blanco, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3281-3288.2001 · Cited by 376 · see citing works

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

Ko, J., Fuccillo, M. V., Malenka, R. C., & Südhof, T. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.12.012 · Cited by 369 · see citing works

Splign: algorithms for computing spliced alignments with identification of paralogs

Kapustin, Y., Souvorov, A. E., Tatusova, T. A., & Lipman, D. J. (2008) · Biology Direct · doi:10.1186/1745-6150-3-20 · Cited by 365 · see citing works

Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

Izquierdo, J. M., Oró, N. M., Bonnal, S., Martínez, C., Castelo, R., Guigó, R., Bilbao, D., & Valcárcel, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.015 · Cited by 364 · see citing works

SR Proteins Function in Coupling RNAP II Transcription to Pre-mRNA Splicing

Das, R., Yu, J., Zhang, Z., Gygi, M. P., Krainer, A. R., Gygi, S. P., & Reed, R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.036 · Cited by 346 · see citing works

Cancer-associated regulation of alternative splicing

Venables, J. P., Klinck, R., Koh, C., Gervais-Bird, J., Bramard, A., Inkel, L., Durand, M., Couture, S., Froehlich, U., Lapointe, E., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1608 · Cited by 340 · see citing works

Nucleosomes are well positioned in exons and carry characteristic histone modifications

Andersson, R., Enroth, S., Rada-Iglesias, A., Wadelius, C., & Komorowski, J. (2009) · Genome Research · doi:10.1101/gr.092353.109 · Cited by 325 · see citing works

AUGUSTUS at EGASP: using EST, protein and genomic alignments for improved gene prediction in the human genome

Stanke, M., Tzvetkova, A., & Morgenstern, B. (2006) · Genome biology · doi:10.1186/gb-2006-7-s1-s11 · Cited by 320 · see citing works

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

Moore, M. J., Wang, Q., Kennedy, C. J., & Silver, P. A. (2010) · Cell · doi:10.1016/j.cell.2010.07.019 · Cited by 316 · see citing works

Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcriptsPreprint

Sanford, J. R., Wang, X., Mort, M. E., VanDuyn, N., Cooper, D. N., Mooney, S. D., Edenberg, H. J., & Liu, Y. (2008) · Genome Research · doi:10.1101/gr.082503.108 · Cited by 309 · see citing works

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs

Grillo, G., Turi, A., Licciulli, F., Mignone, F., Liuni, S., Banfi, S., Gennarino, V. A., Horner, D. S., Pavesi, G., Picardi, E., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp902 · Cited by 308 · see citing works

Splicing regulates NAD metabolite binding to histone macroH2A

Kustatscher, G., Hothorn, M., Pugieux, C., Scheffzek, K., & Ladurner, A. G. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb956 · Cited by 300 · see citing works

Mutually Exclusive Splicing of the Insect Dscam Pre-mRNA Directed by Competing Intronic RNA Secondary Structures

Graveley, B. R. (2005) · Cell · doi:10.1016/j.cell.2005.07.028 · Cited by 295 · see citing works

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

Chalaris, A., Garbers, C., Rabe, B., Rose‐John, S., & Scheller, J. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.007 · Cited by 291 · see citing works

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.

Yan, M., Kanbe, E., Peterson, L. F., Boyapati, A., Miao, Y., Wang, Y., Chen, I.-M., Chen, Z., Rowley, J. D., Willman, C. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1443 · Cited by 279 · see citing works

The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing

Kishore, S., Khanna, A., Zhang, Z., Hui, J., Balwierz, P. J., Stefan, M., Beach, C. M., Nicholls, R. D., Zavolan, M., & Stamm, S. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp585 · Cited by 279 · see citing works

Female-specific insect lethality engineered using alternative splicing

Fu, G., Condon, K. C., Epton, M. J., Gong, P., Jin, L., Condon, G. C., Morrison, N. I., Dafa’alla, T., & Alphey, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1283 · Cited by 272 · see citing works

G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+Channels Is Dependent on a Shank-Binding Domain

Olson, P. A., Tkatch, T., Hernández‐López, S., Ulrich, S., Ilijić, E., Mugnaini, E., Zhang, H., Борисович, Б. И., & Surmeier, D. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3327-04.2005 · Cited by 270 · see citing works

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

Llorian, M., Schwartz, S., Clark, T. A., Hollander, D., Tan, L.-Y., Spellman, R., Gordon, A., Schweitzer, A. C., de la Grange, P., Ast, G., et al. (2010) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1881 · Cited by 263 · see citing works

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

Bluemlein, K., Grüning, N., Feichtinger, R. G., Lehrach, H. R., Kofler, B., & Ralser, M. (2011) · Oncotarget · doi:10.18632/oncotarget.278 · Cited by 254 · see citing works

Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion

Chen, Z., Gore, B. B., Long, H., Ma, L., & Tessier‐Lavigne, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.016 · Cited by 251 · see citing works

Regulation of Alternative Splicing by Reversible Protein Phosphorylation

Stamm, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700034200 · Cited by 250 · see citing works

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

Varani, L., Hasegawa, M., Spillantini, M. G., Smith, M. J., Murrell, J. R., Ghetti, B. F., Klug, A., Goedert, M., & Varani, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8229 · Cited by 248 · see citing works

iCLIP Predicts the Dual Splicing Effects of TIA-RNA Interactions

Wang, Z., Kayikci, M., Briese, M., Zarnack, K., Luscombe, N. M., Rot, G., Zupan, B., Curk, T., & Ule, J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000530 · Cited by 242 · see citing works

RegRNA: an integrated web server for identifying regulatory RNA motifs and elements

Huang, H.-L., Chien, C.-H., Jen, K.-H., & Huang, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl333 · Cited by 239 · see citing works

Conservation of an RNA regulatory map between Drosophila and mammalsPreprint

Brooks, A. N., Yang, L. C., Duff, M. O., Hansen, K. D., Park, J. W., Dudoit, S., Brenner, S. E., & Graveley, B. R. (2010) · Genome Research · doi:10.1101/gr.108662.110 · Cited by 236 · see citing works

Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau

Bhaskar, K., Yen, S.-H. C., & Lee, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505895200 · Cited by 223 · see citing works

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Behzadnia, N., Golas, M. M., Hartmuth, K., Sander, B. O., Kastner, B., Deckert, J., Dube, P., Will, C. L., Urlaub, H., Stark, H., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601631 · Cited by 218 · see citing works

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients

Sadakata, T., Washida, M., Iwayama, Y., Shoji, S., Sato, Y., Ohkura, T., Katoh-Semba, R., Nakajima, M., Sekine, Y., Tanaka, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29031 · Cited by 218 · see citing works

Alternatively Spliced Lipin Isoforms Exhibit Distinct Expression Pattern, Subcellular Localization, and Role in Adipogenesis

Péterfy, M., Phan, J. P., & Reue, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503885200 · Cited by 215 · see citing works

Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function

Günzel, D., Stuiver, M., Kausalya, P. J., Haisch, L., Krug, S. M., Rosenthal, R., Meij, I. C., Hunziker, W., Fromm, M., & Müller, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.040113 · Cited by 214 · see citing works

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

Ferrera, L., Caputo, A., Ubby, I., Bussani, E., Zegarra‐Moran, O., Ravazzolo, R., Pagani, F., & Galietta, L. J. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046607 · Cited by 212 · see citing works

Survivin splice variants regulate the balance between proliferation and cell death

Caldas, H., Jiang, Y., Holloway, M. P., Fangusaro, J., Mahotka, C., Conway, E. M., & Altura, R. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208350 · Cited by 200 · see citing works

Pre-mRNA Secondary Structures Influence Exon Recognition

Hiller, M., Zhang, Z., Backofen, R., & Stamm, S. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030204 · Cited by 199 · see citing works

Hybrid Receptors Formed by Insulin Receptor (IR) and Insulin-like Growth Factor I Receptor (IGF-IR) Have Low Insulin and High IGF-1 Affinity Irrespective of the IR Splice Variant

Slaaby, R., Schäffer, L., Lautrup-Larsen, I., Andersen, A. S., Shaw, A. C., Mathiasen, I. S., & Brandt, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605189200 · Cited by 198 · see citing works

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

Sun, S., Zhang, Z., Sinha, R., Karni, R., & Krainer, A. R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1750 · Cited by 197 · see citing works

A catalog of SCN1A variants

Lossin, C. (2008) · Brain and Development · doi:10.1016/j.braindev.2008.07.011 · Cited by 195 · see citing works

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays

Sugnet, C. W., Srinivasan, K., Clark, T. A., O’Brien, G. S., Cline, M., Wang, H., Williams, A., Kulp, D., Blume, J. E., Haussler, D. H., et al. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020004 · Cited by 194 · see citing works

Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells

Adato, A., Lefevre, G. M., Delprat, B., Michel, V., Michalski, N., Chardenoux, S., Weil, D., El-Amraoui, A., & Petit, C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi416 · Cited by 185 · see citing works

POU5F1 Isoforms Show Different Expression Patterns in Human Embryonic Stem Cells and Preimplantation Embryos

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Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences

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Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

Keats, J. J., Maxwell, C. A., Taylor, B. J., Hendzel, M. J., Chesi, M., Bergsagel, P. L., Larratt, L. M., Mant, M. J., Reiman, T., Belch, A. R., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3704 · Cited by 183 · see citing works

fruitless regulates aggression and dominance in Drosophila

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Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA

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A Splicing Variant of the RON Transcript Induces Constitutive Tyrosine Kinase Activity and an Invasive Phenotype

Collesi, C., Santoro, M. M., Gaudino, G., & Comoglio, P. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5518 · Cited by 177 · see citing works

Chromatin, transcript elongation and alternative splicing

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Angiomotin Regulates Endothelial Cell-Cell Junctions and Cell Motility

Bratt, A., Birot, O., Sinha, I., Veitonmäki, N., Aase, K., Ernkvist, M., & Holmgren, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503915200 · Cited by 173 · see citing works

Genome-wide analysis of alternative splicing in Caenorhabditis elegansPreprint

Ramani, A. K., Calarco, J. A., Pan, Q., Mavandadi, S., Wang, Y., Nelson, A. C., Lee, L. J., Morris, Q., Blencowe, B. J., Zhen, M., et al. (2010) · Genome Research · doi:10.1101/gr.114645.110 · Cited by 170 · see citing works

The Roles of Versican V1 and V2 Isoforms in Cell Proliferation and Apoptosis

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Coupling Transcription and Alternative Splicing

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Structures of APRIL-Receptor Complexes

Hymowitz, S. G., Patel, D. R., Wallweber, H. J. A., Runyon, S., Yan, M., Yin, J., Shriver, S. K., Gordon, N. C., Pan, B., Skelton, N. J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411714200 · Cited by 167 · see citing works

Functional genetic analysis of mutations implicated in a human speech and language disorder

Vernes, S. C., Nicod, J., Elahi, F. M., Coventry, J. A., Kenny, N., Coupe, A.-M., Bird, L. E., Davies, K. E., & Fisher, S. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl392 · Cited by 167 · see citing works

Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread

Narla, G., DiFeo, A. V., Yao, S., Banno, A., Hod, E. A., Reeves, H. L., Qiao, R., Camacho‐Vanegas, O., Levine, A. C., Kirschenbaum, A. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0217 · Cited by 166 · see citing works

Polypyrimidine Tract Binding Protein Blocks the 5′ Splice Site-Dependent Assembly of U2AF and the Prespliceosomal E Complex

Sharma, S., Falick, A. M., & Black, D. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.014 · Cited by 165 · see citing works

Lipins: Multifunctional Lipid Metabolism Proteins

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Insights into the connection between cancer and alternative splicing

Kim, E., Goren, A., & Ast, G. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.10.001 · Cited by 162 · see citing works

Ras-induced Modulation of CXCL10 and Its Receptor Splice Variant CXCR3-B in MDA-MB-435 and MCF-7 Cells: Relevance for the Development of Human Breast Cancer

Datta, D. B., Flaxenburg, J. A., Laxmanan, S., Geehan, C. S., Grimm, M. R., Waaga-Gasser, A. M., Briscoe, D. M., & Pal, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4345 · Cited by 162 · see citing works

Characterization of the Human LPIN1-encoded Phosphatidate Phosphatase Isoforms

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Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer

Misquitta-Ali, C. M., Cheng, E., O’Hanlon, D., Liu, G., McGlade, C. J., Tsao, M., & Blencowe, B. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00709-10 · Cited by 160 · see citing works

Differential Role of N-Type Calcium Channel Splice Isoforms in Pain

Altier, C., Dale, C. S., Kisilevsky, A. E., Chapman, K., Castiglioni, A. J., Matthews, E. A., Evans, R. M., Dickenson, A. H., Lipscombe, D., Vergnolle, N., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0307-07.2007 · Cited by 159 · see citing works

Discovery and Analysis of Evolutionarily Conserved Intronic Splicing Regulatory Elements

Yeo, G. W.-M., Nostrand, E. L. V., & Liang, T. Y. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030085 · Cited by 158 · see citing works

An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exonsPreprint

Lee, J.-A., Tang, Z., & Black, D. L. (2009) · Genes & Development · doi:10.1101/gad.1837009 · Cited by 158 · see citing works

Identification of Common Genetic Variation That Modulates Alternative Splicing

Hull, J., Campino, S. G., Rowlands, K., Chan, M., Copley, R. R., Taylor, M. S., Rockett, K. A., Elvidge, G. P., Keating, B. J., Knight, J. C., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030099 · Cited by 157 · see citing works

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

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Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes

Wang, J. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki810 · Cited by 156 · see citing works

Global regulation of alternative splicing during myogenic differentiation

Bland, C. S., Wang, E. T., Vu, A. Q., David, M. P., Castle, J. C., Johnson, J. M., Burge, C. B., & Cooper, T. A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq614 · Cited by 153 · see citing works

A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization

Feng, Y., Li, X., Wang, L., Zhou, L., & Gorodeski, G. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602999200 · Cited by 152 · see citing works

Selective Knockdown of the Long Variant of Cellular FLICE Inhibitory Protein Augments Death Receptor-mediated Caspase-8 Activation and Apoptosis

Sharp, D. A., Lawrence, D. A., & Ashkenazi, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413962200 · Cited by 152 · see citing works

Alternatively spliced tissue factor induces angiogenesis through integrin ligation

van den Berg, Y. W., van den Hengel, L. G., Myers, H. R., Ayachi, O., Jordanova, E. S., Ruf, W., Spek, C. A., Reitsma, P. H., Bogdanov, V. Y., & Versteeg, H. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905325106 · Cited by 150 · see citing works

A Novel Splice Variant of GLI1 That Promotes Glioblastoma Cell Migration and Invasion

Lo, H., Zhu, H., Cao, X., Aldrich, A. J., & Ali‐Osman, F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0886 · Cited by 150 · see citing works

Alternative splicing of conserved exons is frequently species-specific in human and mouse

Pan, Q., Bakowski, M. A., Morris, Q., Zhang, W., Frey, B. J., Hughes, T. R., & Blencowe, B. J. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.12.004 · Cited by 149 · see citing works

A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones

Gooding, C., Clark, F., Wollerton, M., Grellscheid, S., Groom, H. C. T., & Smith, C. W. J. (2006) · Genome biology · doi:10.1186/gb-2006-7-1-r1 · Cited by 149 · see citing works

Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1α

Zhang, Y., Huypens, P., Adamson, A. W., Chang, J. S., Henagan, T. M., Boudreau, A., Lenard, N. R., Burk, D. H., Klein, J. C., Perwitz, N., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.037556 · Cited by 148 · see citing works

Multiple Alternative Splicing Markers for Ovarian Cancer

Klinck, R., Bramard, A., Inkel, L., Dufresne‐Martin, G., Gervais-Bird, J., Madden, R., Paquet, É. R., Koh, C., Venables, J. P., Prinos, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2580 · Cited by 147 · see citing works

Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin

Lüke, Y., Zaim, H., Karakesisoglou, I., Jaeger, V. M., Sellin, L. K., Lu, W., Schneider, M., Neumann, S., Beijer, Å., Munck, M., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.019075 · Cited by 146 · see citing works

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

Novikov, L., Park, J. W., Chen, H., Klerman, H., Jalloh, A. S., & Gamble, M. J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05244-11 · Cited by 146 · see citing works

Alternative splicing: global insights

Hallegger, M., Llorian, M., & Smith, C. W. J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07521.x · Cited by 143 · see citing works

Useful ‘junk’: Alu RNAs in the human transcriptome

Häsler, J., Samuelsson, T., & Strub, K. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7084-0 · Cited by 142 · see citing works

Isoform and Splice-Variant Specific Functions of Dynamin-2 Revealed by Analysis of Conditional Knock-Out Cells

Liu, Y., Surka, M. C., Schroeter, T., Lukiyanchuk, V., & Schmid, S. L. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-08-0890 · Cited by 141 · see citing works

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

Weise, A., Bruser, K., Elfert, S., Wallmen, B., Wittel, Y., Wöhrle, S., & Hecht, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1197 · Cited by 139 · see citing works

An intronic element contributes to splicing repression in spinal muscular atrophy

Kashima, T., Rao, N., & Manley, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700343104 · Cited by 133 · see citing works

Positive and Negative Regulation of Nuclear Factor-κB-mediated Transcription by IκB-ζ, an Inducible Nuclear Protein

Motoyama, M., Yamazaki, S., Eto-Kimura, A., Takeshige, K., & Muta, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412738200 · Cited by 131 · see citing works

Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies

Dhir, A., & Buratti, E. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07520.x · Cited by 129 · see citing works

Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition

Yu, Y., Maroney, P. A., Denker, J. A., Zhang, X. H.-F., Dybkov, O., Lührmann, R., Jankowsky, E., Chasin, L. A., & Nilsen, T. W. (2008) · Cell · doi:10.1016/j.cell.2008.10.046 · Cited by 129 · see citing works

MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development

Kalsotra, A., Wang, K., Li, P.-F., & Cooper, T. A. (2010) · Genes &amp; Development · doi:10.1101/gad.1894310 · Cited by 129 · see citing works

Reciprocal intronic and exonic histone modification regions in humans

Huff, J. T., Plocik, A. M., Guthrie, C., & Yamamoto, K. R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1924 · Cited by 128 · see citing works

MicroRNAs-10a and -10b Contribute to Retinoic Acid-induced Differentiation of Neuroblastoma Cells and Target the Alternative Splicing Regulatory Factor SFRS1 (SF2/ASF)

Meseguer, S., Mudduluru, G., Escamilla, J. M., Allgayer, H., & Barettino, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167817 · Cited by 127 · see citing works

Alternative Splicing of Vitamin D-24-Hydroxylase

Ren, S., Nguyen, L., Wu, S., Encinas, C., Adams, J. S., & Hewison, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414522200 · Cited by 126 · see citing works

FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus

Fletcher, R. B., Baker, J. C., & Harland, R. M. (2006) · Development · doi:10.1242/dev.02342 · Cited by 126 · see citing works

A Smooth Muscle Cav1.2 Calcium Channel Splice Variant Underlies Hyperpolarized Window Current and Enhanced State-dependent Inhibition by Nifedipine

Liao, P. H., Yu, D., Li, G., Yong, T. F., Soon, J.-L., Chua, Y. L., & Soong, T. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705478200 · Cited by 125 · see citing works

Functional coupling of RNAP II transcription to spliceosome assemblyPreprint

Das, R., Dufu, K., Romney, B., Feldt, M. C., Elenko, M. P., & Reed, R. (2006) · Genes & Development · doi:10.1101/gad.1397406 · Cited by 125 · see citing works

Global analysis of positive and negative pre-mRNA splicing regulators in DrosophilaPreprint

Blanchette, M., Green, R. E., Brenner, S. E., & Rio, D. C. (2005) · Genes & Development · doi:10.1101/gad.1314205 · Cited by 124 · see citing works

A Structure-based Model of the c-Myc/Bin1 Protein Interaction Shows Alternative Splicing of Bin1 and c-Myc Phosphorylation are Key Binding Determinants

Pineda‐Lucena, A., Ho, C. S. W., Mao, D. Y. L., Sheng, Y., Laister, R. C., Muhandiram, R., Lü, Y., Seet, B. T., Katz, S., Szyperski, T., et al. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.046 · Cited by 124 · see citing works

Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis

Chawla, G., Lin, C.-H., Han, A., Shiue, L., Ares, M., & Black, D. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01349-08 · Cited by 124 · see citing works

The discovery of split genes and RNA splicing

Sharp, P. A. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.04.002 · Cited by 122 · see citing works

In Vivo and In Vitro Studies Support That a New Splicing Isoform of OLR1 Gene Is Protective Against Acute Myocardial Infarction

Mango, R., Biocca, S., Vecchio, F. D., Clementi, F., Sangiuolo, F. C., Amati, F., Filareto, A., Grelli, S., Spitalieri, P., Filesi, I., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000174563.62625.8e · Cited by 120 · see citing works

RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5′ Splice Site

Kar, A. N., Fushimi, K., Zhou, X., Ray, P., Chen, S., Chen, X., Liu, Z., Chen, S., & Wu, J. Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01149-10 · Cited by 120 · see citing works

Autoregulation of Fox protein expression to produce dominant negative splicing factors

Damianov, A., & Black, D. L. (2010) · RNA · doi:10.1261/rna.1838210 · Cited by 120 · see citing works

Genomic features defining exonic variants that modulate splicing

Woolfe, A., Mullikin, J. C., & Elnitski, L. L. (2010) · Genome biology · doi:10.1186/gb-2010-11-2-r20 · Cited by 119 · see citing works

The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species

Kim, N., Alekseyenko, A. V., Roy, M., & Lee, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl884 · Cited by 117 · see citing works

UMD (Universal Mutation Database): 2005 update

Béroud, C., Hamroun, D., Collod‐Béroud, G., Boileau, C., Soussi, T., & Claustres, M. (2005) · Human Mutation · doi:10.1002/humu.20210 · Cited by 116 · see citing works

ΔBAFF, a Splice Isoform of BAFF, Opposes Full-Length BAFF Activity In Vivo in Transgenic Mouse Models

Gavin, A. L., Duong, B. H., Skog, P. D., Aït‐Azzouzene, D., Greaves, D. R., Scott, M. L., & Nemazee, D. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.319 · Cited by 115 · see citing works

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

Bao, J., Lu, Z., Joseph, J. J., Carabenciov, D., Dimond, C. C., Pang, L., Samsel, L., McCoy, J. P., Leclerc, J., Nguyen, P., et al. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22531 · Cited by 115 · see citing works

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

Gonçalves, V., Matos, P., & Jordan, P. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp317 · Cited by 113 · see citing works

Rescuing Z ⁺ agrin splicing in <i>Nova</i> null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing

Ruggiu, M., Herbst, R., Kim, N., Jevsek, M., Fak, J. J., Mann, M. A., Fischbach, G., Burden, S. J., & Darnell, R. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813112106 · Cited by 113 · see citing works

Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothoraxPreprint

Noro, B., Culí, J., McKay, D. J., Zhang, W., & Mann, R. S. (2006) · Genes & Development · doi:10.1101/gad.1412606 · Cited by 112 · see citing works

Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions

Pan, Y., Xu, J., Xu, M., Rossi, G. C., Matulonis, J. E., & Pasternak, G. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811586106 · Cited by 112 · see citing works

Alternative trans ‐splicing: a novel mode of pre‐mRNA processing

Horiuchi, T., & Aigaki, T. (2006) · Biology of the Cell · doi:10.1042/bc20050002 · Cited by 111 · see citing works

Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin

Liu, X., Yang, P. S., Yang, W., & Yue, D. T. (2010) · Nature · doi:10.1038/nature08766 · Cited by 111 · see citing works

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertilePreprint

Dunn, N. R., Koonce, C. H., Anderson, D. C., Islam, A., Bikoff, E. K., & Robertson, E. J. (2005) · Genes & Development · doi:10.1101/gad.1243205 · Cited by 108 · see citing works

A Splice Variant of CD99 Increases Motility and MMP-9 Expression of Human Breast Cancer Cells through the AKT-, ERK-, and JNK-dependent AP-1 Activation Signaling Pathways

Byun, H.-J., Hong, I., Kim, E., Jin, Y., Jeoung, D., Hahn, J.-H., Kim, Y.-M., Park, S. H., & Lee, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605483200 · Cited by 105 · see citing works

Coactivator-associated Arginine Methyltransferase 1, CARM1, Affects Pre-mRNA Splicing in an Isoform-specific Manner*♦

Ohkura, N., Takahashi, M., Yaguchi, H., Nagamura, Y., & Tsukada, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502173200 · Cited by 105 · see citing works

New isoforms of rat Aquaporin-4

Moe, S. E., Sorbo, J. G., Sogaard, R., Zeuthen, T., Ottersen, O. P., & Holen, T. (2008) · Genomics · doi:10.1016/j.ygeno.2007.12.003 · Cited by 103 · see citing works

Steroid Receptor Coactivator-1 Splice Variants Differentially Affect Corticosteroid Receptor Signaling

Meijer, O. C., Kalkhoven, E., van der Laan, S., Steenbergen, P. J., Houtman, S., Dijkmans, T. F., Pearce, D., & de Kloet, E. R. (2004) · Endocrinology · doi:10.1210/en.2004-0411 · Cited by 103 · see citing works

The Novel CXCL12γ Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4

Laguri, C., Sadir, R., Rueda, P., Baleux, F., Gans, P., Arenzana‐Seisdedos, F., & Lortat‐Jacob, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001110 · Cited by 103 · see citing works

A Novel Splice Variant of Interleukin-1 Receptor (IL-1R)-Associated Kinase 1 Plays a Negative Regulatory Role in Toll/IL-1R-Induced Inflammatory Signaling

Rao, N. L., Nguyen, S. M., Ngo, K., & Fung‐Leung, W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6521-6532.2005 · Cited by 103 · see citing works

Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc

López, V., & Kelleher, S. L. (2009) · Biochemical Journal · doi:10.1042/bj20081189 · Cited by 102 · see citing works

Intronic polyadenylation signal sequences and alternate splicing generate human soluble Fltl variants and regulate the abundance of soluble Flt1 in the placenta

Thomas, C. P., Andrews, J. I., & Liu, K. Z. (2007) · The FASEB Journal · doi:10.1096/fj.07-8809com · Cited by 102 · see citing works

SFmap: a web server for motif analysis and prediction of splicing factor binding sites

Paz, I., Akerman, M., Dror, I., Kosti, I., & Mandel-Gutfreund, Y. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq444 · Cited by 102 · see citing works

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

Hövelmeyer, N., Wunderlich, F. T., Massoumi, R., Jakobsen, C. G., Song, J., Wörns, M., Merkwirth, C., Kovalenko, A., Aumailley, M., Strand, D. J., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070318 · Cited by 102 · see citing works

Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different Manners

Levy, S. F., LeBoeuf, A. C., Massie, M. R., Jordan, M. A., Wilson, L., & Feinstein, S. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413490200 · Cited by 102 · see citing works

Characterization of GPRA, a Novel G Protein–Coupled Receptor Related to Asthma

Vendelin, J., Pulkkinen, V., Rehn, M., Pirskanen, A., Räisänen-Sokolowski, A. K., Laitinen, A., Laitinen, L. A., Kere, J., & Laitinen, T. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0405oc · Cited by 102 · see citing works

Human–mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation

Kol, G., Lev-Maor, G., & Ast, G. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi164 · Cited by 99 · see citing works

A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding

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Developments in RNA Splicing and Disease

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A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies

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Novel Splice Variants of ING4 and Their Possible Roles in the Regulation of Cell Growth and Motility

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Alternative Pre-mRNA Splicing Governs Expression of a Conserved Acidic Transactivation Domain in Myocyte Enhancer Factor 2 Factors of Striated Muscle and Brain

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ERK1c regulates Golgi fragmentation during mitosis

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Alternative splicing: regulation of HIV‐1 multiplication as a target for therapeutic action

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A soluble mouse brain splice variant of type 2α corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity

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Fox-3 and PSF interact to activate neural cell-specific alternative splicing

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The <i>Drosophila</i> Class B Scavenger Receptor NinaD-I Is a Cell Surface Receptor Mediating Carotenoid Transport for Visual Chromophore Synthesis

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Splice Variants of the Human Zinc Transporter ZnT5 (SLC30A5) Are Differentially Localized and Regulated by Zinc through Transcription and mRNA Stability

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Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells

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A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing

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Ischemia Induces a Translocation of the Splicing Factor tra2-β1 and Changes Alternative Splicing Patterns in the Brain

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A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel α-subunits

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Atherosclerosis-related molecular alteration of the human Ca V 1.2 calcium channel α 1C subunit

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Alternative Splicing of Human Insulin-Degrading Enzyme Yields a Novel Isoform with a Decreased Ability To Degrade Insulin and Amyloid β-Protein

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Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress

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Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

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Alternative Splicing of <i>Cyr61</i> Is Regulated by Hypoxia and Significantly Changed in Breast Cancer

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Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles

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An Essential Role of Alternative Splicing of c-myc Suppressor FUSE-Binding Protein–Interacting Repressor in Carcinogenesis

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Characterization of the Intracellular Localization, Processing, and Secretion of Two Glial Cell Line-Derived Neurotrophic Factor Splice Isoforms

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Ca V 2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: Implications for calcium channelopathies

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ApoE receptor 2 controls neuronal survival in the adult brain

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Fas-activated Serine/Threonine Kinase (FAST K) Synergizes with TIA-1/TIAR Proteins to Regulate Fas Alternative Splicing

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Mechanisms and Regulation of Alternative Pre-mRNA Splicing

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Gene co-expression analysis for functional classification and gene–disease predictions

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Molecular mechanisms of ROS production and oxidative stress in diabetes

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Introducing Protein Intrinsic Disorder

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Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

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Alternative splicing as a source of phenotypic diversity

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The Expanding Landscape of Alternative Splicing Variation in Human Populations

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Alternative Splicing May Not Be the Key to Proteome Complexity

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Misregulation of Pre-mRNA Alternative Splicing in Cancer

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Proteomic and interactomic insights into the molecular basis of cell functional diversity

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A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

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Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues

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Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects

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Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genesPreprint

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Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals

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RNA-binding proteins control gene expression and cell fate in the immune system

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Alternative Splicing and Protein Diversity: Plants Versus Animals

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SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization

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Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticityPreprint

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The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development

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The RNA Splicing Response to DNA Damage

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Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer’s disease, Parkinson’s disease

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FFPred 3: feature-based function prediction for all Gene Ontology domains

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DYRK1A inhibitors for disease therapy: Current status and perspectives

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The state of play in higher eukaryote gene annotation

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Genetic Control of Gonadal Sex Determination and Development.

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RNA-guided transcriptional activation via CRISPR/dCas9 mimics overexpression phenotypes in Arabidopsis

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Genome-Wide Detection of Condition-Sensitive Alternative Splicing in Arabidopsis Roots

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RNA splicing in human disease and in the clinic

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QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

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Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity

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SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes

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Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies

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An integrated transcriptional analysis of the developing human retina

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Alternative Splicing of G9a Regulates Neuronal Differentiation

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