The DOI matches its Crossref record.
The Physical State of Human Papillomavirus Type 16 DNA in Benign and Malignant Genital Tumours
Abstract
Cloned DNA from human papillomavirus (HPV) type 16 was subjected to restriction enzyme analysis. A genome size of 7.8 +/- 0.1 kb was determined and restriction maps were prepared. Fragments of HPV 16 DNA were nick-translated and hybridized with fragments of HPV 6b DNA. The two genomes appeared to be colinear. The physical state of HPV 16 DNA in genital tumours was analysed. In each of six benign tumours the viral DNA was detected exclusively as 8 kb circles. In four malignant tumours the viral DNA appeared to be integrated within the host genome but one cervical carcinoma and one case of Bowen's disease also contained oligomeric episomal molecules of viral DNA. One cervical carcinoma (WV 2965), containing only integrated viral DNA, was examined in detail. HPV 16 DNA was integrated as head-to-tail tandem repeats at more than one site. Three virus/cell junction fragments from this tumour were cloned. Two contained lengths of repetitive cellular DNA and one a length of apparently single copy cellular DNA.
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Cited by
Münger, K., Phelps, W. C., Bubb, V, Howley, P. M., & Schlegel, R. (1989) · Journal of Virology · doi:10.1128/jvi.63.10.4417-4421.1989 · Cited by 1,030
Halbert, C. L., Demers, G. W., & Galloway, D. A. (1991) · Journal of Virology · doi:10.1128/jvi.65.1.473-478.1991 · Cited by 462
Integration of high‐risk human papillomavirus: a key event in cervical carcinogenesis?
Pett, M., & Coleman, N. (2007) · The Journal of Pathology · doi:10.1002/path.2192 · Cited by 451
Cullen, A. P., Reid, R., Campion, M., & Lörincz, A. T. (1991) · Journal of Virology · doi:10.1128/jvi.65.2.606-612.1991 · Cited by 445
Squamous cell carcinoma of the skin (excluding lip and oral mucosa)
Johnson, T. M., Rowe, D. E., Nelson, B. R., & Swanson, N. A. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70074-p · Cited by 414
Metadata
- Authors
- Durst, M., Kleinheinz, A., Hotz, M., & Gissmann, L.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 1985-07-01
- Volume
- 66
- Issue
- 7
- Pages
- 1515-1522
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2151066134
- Cited by
- 477
- References
- 0
- FWCI
- 36.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Durst, M., Kleinheinz, A., Hotz, M., & Gissmann, L. (1985). The Physical State of Human Papillomavirus Type 16 DNA in Benign and Malignant Genital Tumours. Journal of General Virology. https://doi.org/10.1099/0022-1317-66-7-1515
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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