The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Latent equid herpesviruses 1 and 4: detection and distinction using the polymerase chain reaction and co-cultivation from lymphoid tissues.
Abstract
The polymerase chain reaction (PCR) and co-cultivation were used to identify the lymphoreticular system as the site of latency of equid herpesvirus I (EHV-1). Primers for PCR were designed from aligned nucleotide sequences of the glycoprotein gB genes to amplify the same region of both the EHV-1 and EHV-4 genomes. Subsequent restriction digests using specific enzymes distinguished the amplified fragments of the EHV-1 genome from those of the EHV-4 genome. Ten weeks following an experimental infection of five ponies with EHV-1, latent virus was detected by PCR and recovered by co-cultivation, predominantly from lymphoid tissues draining the respiratory tract. Significantly, latent EHV-1 also persisted in peripheral blood leukocytes (PBL). Latent EHV-4, presumably from a preceding natural infection, was also detected in some tissues, including PBL, from all animals. Of additional interest was the recovery of EHV-1 and -4 only in the presence of the ubiquitous EHV-2.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“EHV-1 has also been shown to establish latency in respiratory associated lymphoid tissues (e.g., mandibular, retropharyngeal and bronchial lymph nodes).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Welch et al., 1992
Citations
Cites
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction
Mullis, K. B., & Faloona, F. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)55023-6 · Cited by 5,762
Latent Herpes Simplex Virus in Spinal Ganglia of Mice
Stevens, J. G., & Cook, M. L. (1971) · Science · doi:10.1126/science.173.3999.843 · Cited by 564
(1986) · PubMed · Cited by 467
Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans
Efstathiou, S., Minson, A. C., Field, H. J., Anderson, J. R., & Wildy, P. (1986) · Journal of Virology · doi:10.1128/jvi.57.2.446-455.1986 · Cited by 214
Endothelial cell infection and thrombosis in paralysis caused by equid herpesvirus-1: equine stroke.
Edington, N., Bridges, C. G., & Patel, J. R. (1986) · Archives of Virology · doi:10.1007/bf01314149 · Cited by 213
CLARK, D. (1995) · Elsevier eBooks · doi:10.1016/b978-012397720-5/50024-4 · Cited by 202
The Family Herpesviridae: General Description, Taxonomy, and Classification
Roizman, B. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4163-5_1 · Cited by 184
Buckmaster, A., Scott, S. D., Sanderson, M. J., Boursnell, M. E. G., Ross, N., & Binns, M. M. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-8-2033 · Cited by 175
Hill, T. J., Altmann, D. M., Blyth, W. A., Harbour, D. A., & Whitby, A. (1984) · Clinics in Dermatology · doi:10.1016/0738-081x(84)90065-8 · Cited by 173
Studdert, M. J., Simpson, T., & Roizman, B. (1981) · Science · doi:10.1126/science.6270790 · Cited by 154
Edington, N., BRIDGES, C. G., & HUCKLE, A. (1985) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1985.tb02524.x · Cited by 148
Herpes Simplex and 'The Herpes Complex': Diverse Observations and A Unifying Hypothesis
Honess, R. W. (1984) · Journal of General Virology · doi:10.1099/0022-1317-65-12-2077 · Cited by 141
Variation in cellular tropism between isolates of equine herpesvirus-1 in foals.
Patel, J. R., Edington, N., & Mumford, J. A. (1982) · Archives of Virology · doi:10.1007/bf01320781 · Cited by 132
Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction
Mullis, K. B., & Faloona, F. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-765560-4.50015-0 · Cited by 125
Serological Detection of Equid Herpesvirus1 Infections of the Respiratory Tract
Thomson, G. R., Mumford, J. A., Campbell, J., GRIFFITHS, L., & Clapham, P. (1976) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1976.tb03291.x · Cited by 122
Rziha, H.-J., Mettenleiter, T. C., Ohlinger, V., & Wittmann, G. (1986) · Virology · doi:10.1016/0042-6822(86)90220-5 · Cited by 111
Equine Herpesvirus 1 Infection of Horses: Studies on the Experimentally Induced Neurologic Disease
Jackson, T. A., Osburn, B. I., Cordy, D. R., & Kendrick, J. W. (1977) · American Journal of Veterinary Research · doi:10.2460/ajvr.1977.38.06.709 · Cited by 98
Whalley, J. M., Robertson, G. R., Scott, N., Hudson, G. C., Bell, C. W., & Woodworth, L. M. (1989) · Journal of General Virology · doi:10.1099/0022-1317-70-2-383 · Cited by 87
Wittmann, G., Jakubík, J., & Ahl, R. (1980) · Archives of Virology · doi:10.1007/bf01314736 · Cited by 85
Persistence of Pseudorabies Virus in Infected Swine
Beran, G. W., Davies, E. B., Arambulo, P. V., Will, L. A., Hill, H. T., & Rock, D. L. (1980) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1980.176.10.998 · Cited by 77
Latent pseudorabies virus infection in pigs.
Sabó, A., & Rajčáni, J. (1976) · PubMed · Cited by 76
Identification and nucleotide sequence of the glycoprotein gB gene of equine herpesvirus 4
Riggio, M. P., Cullinane, A., & Onions, D. E. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1123-1133.1989 · Cited by 75
Scott, J. C., Dutta, S. K., & Myrup, A. (1983) · American Journal of Veterinary Research · doi:10.2460/ajvr.1983.44.07.1344 · Cited by 71
Characterization of the Genome of Equine Herpesvirus 1 Subtype 2
Cullinane, A., Rixon, F. J., & Davison, A. J. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-7-1575 · Cited by 70
Rapid subtyping of equine herpesvirus 1 with monoclonal antibodies
Yeargan, M. R., Allen, G. P., & Bryans, J. T. (1985) · Journal of Clinical Microbiology · doi:10.1128/jcm.21.5.694-697.1985 · Cited by 63
Isolation of herpesvirus from equine leukocytes: comparison with equine rhinopneumonitis virus.
Kemény, L. V., & Pearson, J. E. (1970) · PubMed · Cited by 61
Studdert, M. J. (1983) · Archives of Virology · doi:10.1007/bf01309272 · Cited by 59
The pathogenicity in mice of respiratory, abortion and paresis isolates of equine herpesvirus-1
Patel, J., & Edington, N. (1983) · Veterinary Microbiology · doi:10.1016/0378-1135(83)90082-2 · Cited by 51
Latency of equine herpesvirus 4 (equine rhinopneumonitis virus)
Browning, G. F., Bulach, D., Ficorilli, N., Roy, E., Thorp, B. H., & Studdert, M. J. (1988) · Veterinary Record · doi:10.1136/vr.123.20.518 · Cited by 41
Burrows, R., & Goodridge, D. (1984) · Springer eBooks · doi:10.1007/978-94-009-5662-9_24 · Cited by 38
Shimizu, T., Ishizaki, R., Ishii, S., Kawakami, Y., Kaji, T., SUGIMURA, K., & Matumoto, M. (1959) · PubMed · Cited by 35
Ben‐Porat, T., Deatly, A. M., Easterday, B. C., Galloway, D. A., Kaplan, A. S., & McGregor, S. (1984) · Springer eBooks · doi:10.1007/978-94-009-5662-9_28 · Cited by 30
DOLL, E. R., & WALLACE, M. E. (1954) · PubMed · Cited by 24
Equine adenovirus 1 isolated from cauda equina neuritis
Edington, N., WRIGHT, J. A., Patel, J., Edwards, G. B., & Griffiths, L. (1984) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)31916-7 · Cited by 23
Rapid diagnosis and characterization of equid herpesvirus 1 using monoclonal antibodies.
Edington, N., BRIDGES, C. G., & Broad, S. (1987) · PubMed · Cited by 11
Human Cytomegalovirus Infections in vitro after Treatment with Arildone
Tyms, A. S., Stevens, R. J., Mobberley, M. A., Ryder, T. A., & Jeffries, D. J. (1984) · Journal of General Virology · doi:10.1099/0022-1317-65-12-2129 · Cited by 9
Olga—oligonucleotide primer design program for the Atari ST
BRIDGES, C. G. (1990) · Computer applications in the biosciences · doi:10.1093/bioinformatics/6.2.124 · Cited by 3
Cited by
Sorted by citations
Patel, J., & Heldens, J. G. M. (2004) · The Veterinary Journal · doi:10.1016/j.tvjl.2004.04.018 · Cited by 287
The trigeminal ganglion is a location for equine herpesvirus 1 latency and reactivation in the horse
Slater, J. D., Borchers, K., Thackray, A. M., & Field, H. J. (1994) · Journal of General Virology · doi:10.1099/0022-1317-75-8-2007 · Cited by 195
Equine Herpesviruses 4 (Equine Rhinopneumonitis Virus) and 1 (Equine Abortion Virus)
Crabb, B. S., & Studdert, M. J. (1995) · Advances in virus research · doi:10.1016/s0065-3527(08)60060-3 · Cited by 180
The prevalence of latent Equid herpesviruses in the tissues of 40 abattoir horses
Edington, N., Welch, H., & GRIFFITHS, L. (1994) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1994.tb04353.x · Cited by 134
The equine immune response to equine herpesvirus-1: The virus and its vaccines
Kydd, J. H., Townsend, H. G. G., & Hannant, D. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.01.005 · Cited by 134
Metadata
- Authors
- Welch, H. M., Bridges, C. G., Lyon, A. M., Griffiths, L., & Edington, N.
- Affiliations
- Royal Veterinary College (GB)
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 1992-02-01
- Volume
- 73
- Issue
- 2
- Pages
- 261-268
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2165142761
- Cited by
- 203
- References
- 41
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 6 · 2013: 12 · 2012: 3
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of General Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- equine herpesvirus 1, viral latency, lymphoid tissue, horses, peripheral blood leukocytes, glycoprotein B gene, restriction fragment length polymorphism, co-culture, viral persistence
- MeSH terms
- Acute Disease, Animals, Base Sequence, DNA, Viral, Herpesvirus 1, Equid, Fluorescent Antibody Technique, Herpesviridae, Herpesviridae Infections, Horse Diseases, Horses, Leukocytes, Lymphoid Tissue, Molecular Sequence Data, Respiratory System, Polymorphism, Restriction Fragment Length, Restriction Mapping, Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review