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Cited by 198

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Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2)

RUDD, B. A. M., HOPWOOD, D. A.·1979·Journal of General Microbiology
DOI 10.1099/00221287-114-1-35
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Abstract

A series of 76 mutants of Streptomyces coelicolor A3(2) specifically blocked in the synthesis of the binaphthoquinone antibiotic actinorhodin were classified into seven phenotypic classes on the basis of antibiotic activity, accumulation of pigmented precursors or shunt products of actinorhodin biosynthesis, and cosynthesis of actinorhodin in pairwise combinations of mutants. The polarity of cosynthetic reactions, and other phenotypic properties, allowed six of the mutant classes to be arranged in the most probable linear sequence of biosynthetic blocks. One member of each mutant class was mapped unambigiguously to the chromosomal linkage map in the short segment between the hisD and guaA loci, suggesting that structural genes for actinorhodin biosynthesis may form an uninterrupted cluster of chromosomal genes.

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Metadata

Authors
RUDD, B. A. M., & HOPWOOD, D. A.
Venue
Journal of General Microbiology
Publisher
Microbiology Society
Published
1979-09-01
Volume
114
Issue
1
Pages
35-43
ISSN
0022-1287 (ISSN-L)
DOI
10.1099/00221287-114-1-35
OpenAlex
W2119893355
Cited by
198
References
0
FWCI
2.26
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2). https://app.cochat.ai/papers/10.1099/00221287-114-1-35
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RUDD, B. A. M., & HOPWOOD, D. A. (1979). Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2). Journal of General Microbiology. https://doi.org/10.1099/00221287-114-1-35

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.