The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Bacterial fibronectin-binding proteins and endothelial cell surface fibronectin mediate adherence of Staphylococcus aureus to resting human endothelial cells
Abstract
Adhesion of Staphylococcus aureus to human endothelial cells is implicated in the pathogenesis of invasive staphylococcal disease. The adhesion to endothelial cells of isogenic mutants defective in defined surface structures was studied. Three strains of S. aureus defective in fibronectin-binding proteins FnBPA and FnBPB showed reduced adhesion. This was fully restored by complementation of a FnBPA- FnBPB- mutant derived from strain 8325-4 with a multicopy plasmid encoding FnBPA or FnBPB. Adhesion of mutants defective in other surface structures was unaffected. Anti-fibronectin antibodies blocked adhesion of 8325-4 to endothelial cells, while adhesion of strains 8325-4, P1 and five clinical isolates was inhibited by the recombinant form of the binding domain of FnBPB (rFNBD) from Streptococcus dysgalactiae. Adherence of bacterial aggregates resulting from the presence of purified fibrinogen was also inhibited by rFNBD protein. Three strains of S. aureus defective in FnBPA and FnBPB were not internalized by endothelial cells. S. aureus FnBPs mediate adhesion to human endothelial cells and are required for subsequent internalization, interactions of potential relevance to pathogenesis and treatment.
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Cites
MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES
Patti, J. M., Allen, B. L., McGavin, M. J., & Höök, M. (1994) · Annual Review of Microbiology · doi:10.1146/annurev.mi.48.100194.003101 · Cited by 1,191
von Eiff, C., Heilmann, C., Proctor, R. A., Woltz, C., Peters, G., & Götz, F. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.15.4706-4712.1997 · Cited by 310 · cited 1×
“Lack of α-toxin production by small colony variants may explain why these can persist in the intracellular niche without causing endothelial cell death (Balwit et al., 1994; von Eiff et al., 1997).”
BackgroundPatel, A. H., Nowlan, P., Weavers, E. D., & Foster, T. (1987) · Infection and Immunity · doi:10.1128/iai.55.12.3103-3110.1987 · Cited by 280
Self-citationBalwit, J. M., Langevelde, P. V., Vann, J. M., & Proctor, R. A. (1994) · Journal of Infectious Diseases · doi:10.1093/infdis/170.4.1033 · Cited by 237
Surface-associated proteins of Staphylococcus aureus:Their possible roles in virulence
Foster, T. J., & McDevitt, D. (1994) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1994.tb06828.x · Cited by 186
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Cited by
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,533
Self-citationPathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Proctor, R. A., von Eiff, C., Kahl, B. C., Becker, K., McNamara, P., Herrmann, M., & Peters, G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1384 · Cited by 1,175
Intracellular staphylococcus aureus: Live-in and let die
Fraunholz, M., & Sinha, B. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00043 · Cited by 377
Wann, E. R., Gurusiddappa, S., & Höök, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13863 · Cited by 300
Metadata
- Authors
- Peacock, S. J., Foster, T. J., Cameron, B. J., & Berendt, A. R.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 1999-12-01
- Volume
- 145
- Issue
- 12
- Pages
- 3477-3486
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2128007276
- Cited by
- 237
- References
- 5
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peacock, S. J., Foster, T. J., Cameron, B. J., & Berendt, A. R. (1999). Bacterial fibronectin-binding proteins and endothelial cell surface fibronectin mediate adherence of Staphylococcus aureus to resting human endothelial cells. Microbiology. https://doi.org/10.1099/00221287-145-12-3477
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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