The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Surface-associated proteins of Staphylococcus aureus:Their possible roles in virulence
Open accessAbstract
A class of proteins that are associated with the cell surface of Gram-positive bacteria has been recognised. Common structural features which are implicated in the proper secretion and attachment of these proteins to the cell surface occur in the C-termini. N-terminal domains interact with the host by binding to soluble host proteins, to matrix proteins or to host cells. They probably have important roles in pathogenicity by allowing bacteria to avoid host defences and by acting as adhesins. Four such proteins of Staphylococcus aureus have been characterised: protein A (immunoglobulin binding protein), fibronectin binding proteins, collagen binding protein and the fibrinogen binding protein (clumping factor). Site-specific mutants are being used to define their roles in pathogenesis in in vitro and in vivo models of adherence and infection.
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“schleiferi [20,21], or glucan binding protein of Streptococcus mutans [19].”
Background
Metadata
- Authors
- Foster, T. J., & McDevitt, D.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Foster, T.J.
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-05
- Volume
- 118
- Issue
- 3
- Pages
- 199-205
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2009387111
- Cited by
- 186
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Health Research Board
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Staphylococcus aureus, cell surface proteins, virulence factors, adhesins, protein A, immunoglobulin binding protein, fibronectin-binding protein, collagen-binding protein, fibrinogen-binding protein, clumping factor, host cell adhesion, site-directed mutants, bacterial pathogenesis
- MeSH terms
- Bacterial Adhesion, Bacterial Proteins, Cell Wall, Staphylococcus aureus, Virulence
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