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Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
Abstract
Broth-culture filtrates of Campylobacter pylori induced non-lethal cytopathic effects in vitro in 7 of 9 mammalian cell lines tested. Transmission electronmicroscopy revealed that the response consisted of intracellular vacuolisation. Intestine 407 cells were among the most responsive and were used for routine assay. About 55% of isolates of C. pylori tested, originating from four geographic regions worldwide, produced cytotoxic activity. The activity was neutralisable by specific antisera to broth-culture filtrates or to sonicated bacteria but not by antisera to other bacterial preparations. Cytotoxic activity was heat-labile (70 degrees C for 30 min), was protease-sensitive and ammonium-sulphate precipitable. It did not pass through an ultrafiltration membrane with a nominal mol.-wt limit of 100 X 10(3). It was concluded that C. pylori can produce a factor that alters cultured cells in vitro. The relevance of this factor to the pathogenesis of gastritis associated with C. pylori remains to be determined.
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Citations
Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Host-Bacterial Interactions in Helicobacter pylori Infection
Amieva, M. R., & El–Omar, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.009 · Cited by 632
Ernst, P. B., & Gold, B. D. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.615 · Cited by 554
Rhead, J. L., Letley, D. P., Mohammadi, M., Hussein, N., Mohagheghi, M. A., Eshagh Hosseini, M., & Atherton, J. C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.056 · Cited by 435
Growth Phase-Dependent Response of Helicobacter pylori to Iron Starvation
Merrell, D. S., Thompson, L. J., Kim, C. C., Mitchell, H., Tompkins, L. S., Lee, A., & Falkow, S. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6510-6525.2003 · Cited by 149
Metadata
- Authors
- Leunk, R. D., Johnson, P. T., David, B. C., Kraft, W. G., & Morgan, D. R.
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 1988-06-01
- Volume
- 26
- Issue
- 2
- Pages
- 93-99
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2135972635
- Cited by
- 671
- References
- 0
- FWCI
- 28.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Leunk, R. D., Johnson, P. T., David, B. C., Kraft, W. G., & Morgan, D. R. (1988). Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. Journal of Medical Microbiology. https://doi.org/10.1099/00222615-26-2-93
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
