Growth Phase-Dependent Response of Helicobacter pylori to Iron Starvation

Merrell, D. Scott; Thompson, Lucinda J.; Kim, Charles C.; Mitchell, Hazel; Tompkins, Lucy S.; Lee, Adrian; Falkow, Stanley

doi:10.1128/iai.71.11.6510-6525.2003

Cited by 149Helicobacter pylori-related gastroenterology studiesBacterial Genetics and BiotechnologyIron Metabolism and Disorders

Growth Phase-Dependent Response of Helicobacter pylori to Iron Starvation

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Merrell, D. Scott, Thompson, Lucinda J., Kim, Charles C., Mitchell, Hazel, Tompkins, Lucy S., Lee, Adrian, Falkow, Stanley·2003·Infection and Immunity

DOI 10.1128/iai.71.11.6510-6525.2003PMC PMC219544

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Abstract

Iron is an essential nutrient that is often found in extremely limited available quantities within eukaryotic hosts. Because of this, many pathogenic bacteria have developed regulated networks of genes important for iron uptake and storage. In addition, it has been shown that many bacteria use available iron concentrations as a signal to regulate virulence gene expression. We have utilized DNA microarray technology to identify genes of the human pathogen Helicobacter pylori that are differentially regulated on a growth-inhibiting shift to iron starvation conditions. In addition, the growth phase-dependent expression of these genes was investigated by examining both exponential and stationary growth phase cultures. We identified known iron-regulated genes, as well as a number of genes whose regulation by iron concentration was not previously appreciated. Included in the list of regulated factors were the known virulence genes cagA, vacA, and napA. We examined the effect of iron starvation on the motility of H. pylori and found that exponential- and stationary-phase cultures responded differently to the stress. We further found that while growing cells are rapidly killed by iron starvation, stationary-phase cells show a remarkable ability to survive iron depletion. Finally, bioinformatic analysis of the predicted promoter regions of the differentially regulated genes led to identification of several putative Fur boxes, suggesting a direct role for Fur in iron-dependent regulation of these genes.

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Iron deficiency increases H. pylori expression of the Cag pathogenicity island, which encodes a type 4 secretion system used to deliver CagA into host cells.
“In either case, iron deficiency increases H. pylori expression of the Cag pathogenicity island that encodes for a type 4 secretion system used to deliver CagA into host cells (Merrell et al., 2003).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Merrell et al., 2003

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Authors: Merrell, D. S., Thompson, L. J., Kim, C. C., Mitchell, H., Tompkins, L. S., Lee, A., & Falkow, S.
Affiliations: Stanford Medicine (US)
UNSW Sydney (AU)
ORCID: Merrell, D. Scott
Kim, Charles C.
Mitchell, Hazel
Tompkins, Lucy S.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2003-11
Volume: 71
Issue: 11
Pages: 6510-6525
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.71.11.6510-6525.2003
PMC: PMC219544
OpenAlex: W2139704756
Cited by: 149
References: 76
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 3 · 2014: 9 · 2013: 8 · 2012: 12
FWCI: 10.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Damon Runyon Cancer Research Foundation
University of New South Wales
National Institutes of Health (DK56339)
Medical Research Council
National Health and Medical Research Council (CA92229, AI38459)
National Cancer Institute (CA 92229, R01CA092229)
National Institute of Allergy and Infectious Diseases (AI 38459, AI 07502-06, R01AI038459, T32AI007502)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-56339, P30DK056339)
Topics: Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: Helicobacter pylori, iron starvation, iron regulation, growth phase, virulence gene expression, CagA, VacA, napA, bacterial motility, Fur protein, Fur box, promoter analysis, iron absorption, stationary phase survival
MeSH terms: Base Sequence, Biological Transport, Flagellin, Iron, Molecular Sequence Data, Nitrogen, Protein Biosynthesis, Gene Expression Regulation, Bacterial, Helicobacter pylori, Computational Biology, Oligonucleotide Array Sequence Analysis, Virulence Factors

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Growth Phase-Dependent Response of Helicobacter pylori to Iron Starvation

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