The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors
Abstract
Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and typhoid fever. The bacteria are able to invade and replicate within host cells, including epithelial cells and macrophages. Pathogenesis of Salmonella is facilitated by a type III secretion system (T3SS) encoded by genes of Salmonella pathogenicity island 2 (SPI-2). Intracellular replication occurs in a specialized membrane compartment, the Salmonella-containing vacuole (SCV), and depends on translocation of approximately 30 effector proteins via the SPI-2 T3SS into the host endomembrane system and cytoplasm. In this review we discuss the many different functions of these effectors, which range from maintaining the integrity of the SCV and its juxtanuclear location, to interference with the host cytoskeleton and immune signalling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Global Burden of Nontyphoidal Salmonella Gastroenteritis
Majowicz, S. E., Musto, J., Scallan, E., Angulo, F. J., Kirk, M., O’Brien, S. J., Jones, T. F., Fazil, A., & Hoekstra, R. M. (2010) · Clinical Infectious Diseases · doi:10.1086/650733 · Cited by 2,442
Membrane curvature and mechanisms of dynamic cell membrane remodelling
McMahon, H. T., & Gallop, J. L. (2005) · Nature · doi:10.1038/nature04396 · Cited by 2,163
The global burden of typhoid fever.
(2004) · Europe PMC (PubMed Central) · Cited by 1,965
The leucine-rich repeat as a protein recognition motif
Kobe, B. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(01)00266-4 · Cited by 1,679
Ubiquitin: structures, functions, mechanisms
Pickart, C. M., & Eddins, M. J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.019 · Cited by 1,407
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Parkhill, J., Dougan, G., James, K. D., Thomson, N. R., Pickard, D., Wain, J., Churcher, C., Mungall, K. L., Bentley, S. D., Holden, M. T. G., et al. (2001) · Nature · doi:10.1038/35101607 · Cited by 1,271
Simultaneous Identification of Bacterial Virulence Genes by Negative Selection
Hensel, M., Shea, J. E., Gleeson, C., Jones, M. D., Dalton, E., & Holden, D. W. (1995) · Science · doi:10.1126/science.7618105 · Cited by 1,198
Self-citationMutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.
Fields, P. I., Swanson, R. V., Haidaris, C. G., & Heffron, F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5189 · Cited by 1,114
Salmonella Interactions with Host Cells: Type III Secretion at Work
Galán, J. E. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.53 · Cited by 732
THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE
Carter, P. B., & Collins, F. M. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.5.1189 · Cited by 664
Cited by
Mitogen-activated protein kinases in innate immunity
Arthur, J. S. C., & Ley, S. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3495 · Cited by 1,855
Baker, P. J., Boucher, D., Bierschenk, D., Tebartz, C., Whitney, P. G., D'Silva, D. B., Tanzer, M. C., Monteleone, M., Robertson, A. A. B., Cooper, M. A., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545655 · Cited by 366
Lamichhane, B., Mawad, A. M. M., Saleh, M., Kelley, W. G., Harrington, P. J., Lovestad, C. W., Amezcua, J., Sarhan, M. M., El Zowalaty, M. E., Ramadan, H., et al. (2024) · Antibiotics · doi:10.3390/antibiotics13010076 · Cited by 353
Nutritional iron turned inside out: intestinal stress from a gut microbial perspective
Kortman, G. A. M., Raffatellu, M., Swinkels, D. W., & Tjalsma, H. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12086 · Cited by 291
Increased colon cancer risk after severe Salmonella infection
Mughini-Gras, L., Schaapveld, M., Kramers, J., Mooij, S., Neefjes-Borst, E. A., Pelt, W. V., & Neefjes, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0189721 · Cited by 133
Metadata
- Authors
- Figueira, R., & Holden, D. W.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2012-05-01
- Volume
- 158
- Issue
- 5
- Pages
- 1147-1161
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2014746756
- Cited by
- 362
- References
- 145
- FWCI
- 38.17
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors. https://app.cochat.ai/papers/10.1099/mic.0.058115-0
- The paper
- Figueira, R., & Holden, D. W. (2012). Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors. Microbiology. https://doi.org/10.1099/mic.0.058115-0
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
