The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Continuous culture – making a comeback?
Abstract
The heyday of continuous culture was in the 1960s, when its versatility and reproducibility were used to address fundamental problems in diverse microbiological fields such as biochemistry, ecology, genetics and physiology. The advent of molecular genetics in the 1970s and 1980s led to a decline in the popularity of continuous culture as a standard laboratory tool. The current trend of studying global proteomics, transcriptomics and metabolomics requires reproducible, reliable and biologically homogeneous datasets with which to approach a given problem. The use of continuous culture techniques can aid the acquisition of such data, and continuous cultures offer advantages over biologically heterogeneous batch cultures, where secondary growth and stress effects can often mask subtle physiological differences and trends. This review is intended to remind microbiologists of the value of continuous cultivation in a wide range of biological investigations, and describes some advantages and recent advances in applications of continuous culture in post-genomic studies.
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Cites
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Cited by
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Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations
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Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast
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Growth control of the eukaryote cell: a systems biology study in yeast
Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., et al. (2007) · Journal of Biology · doi:10.1186/jbiol54 · Cited by 263
Cultivation of Microalgae for Biodiesel Production: A Review on Upstream and Downstream Processing
Tan, X. B., Lam, M. K., Uemura, Y., Lim, J. W., Wong, C. Y., & Lee, K. T. (2018) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2017.08.010 · Cited by 224
Metadata
- Authors
- Hoskisson, P. A., & Hobbs, G.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2005-10-01
- Volume
- 151
- Issue
- 10
- Pages
- 3153-3159
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2101320046
- Cited by
- 262
- References
- 47
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
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