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Multiple novel astrovirus species in human stool
Open accessAbstract
Diarrhoea remains a significant cause of morbidity and mortality in developing countries where numerous cases remain without identified aetiology. Astroviruses are a recently identified cause of animal gastroenteritis which currently includes two species suspected of causing human diarrhoea. Using pan-astrovirus RT-PCR, we analysed human stool samples from different continents for astrovirus-related RNA sequences. We identified variants of the two known human astrovirus species plus, based on genetic distance criteria, three novel astrovirus species all distantly related to mink and ovine astroviruses, which we provisionally named HMOAstV species A–C. The complete genome of species A displayed all the conserved characteristics of mammalian astroviruses. Each of the now three groups of astroviruses found in human stool (HAstV, AstV-MLB and HMOAstV) were more closely related to animal astroviruses than to each other, indicating that human astroviruses may periodically emerge from zoonotic transmissions. Based on the pathogenic impact of their closest phylogenetic relatives in animals, further investigations of the role of HMOAstV, so far detected in Nigeria, Nepal and Pakistan, in human gastroenteritis are warranted.
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“Some human astroviruses are more closely related to those in animals than to each other, suggesting that these viruses periodically emerge from zoonotic origins (Kapoor et al. 2009).”
From Red fox viromes in urban and rural landscapes (2020) · cites this paper as Kapoor et al. 2009
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Research works printed but not linked: 34
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Items 101–200 of 200
Human Astrovirus MLB Replication In Vitro: Persistence in Extraintestinal Cell Lines
Vu, D., Bosch, A., Pintó, R., Ribes, E., & Guix, S. (2019) · Journal of Virology · doi:10.1128/jvi.00557-19 · Cited by 19
Novel human astroviruses: challenges for developing countries
Krishnan, T. (2014) · VirusDisease · doi:10.1007/s13337-014-0202-3 · Cited by 19
“A novel human astrovirus (Ast-VA1) strain that was associated with acute gastroenteritis outbreak was reported from USA [10] and highly divergent strains (AstV-VA2, AstVMLB2 and Ast-VA3) were reported in children from USA [16].”
BackgroundInfluentialThe Molecular Virology of Enteric Viruses
Buesa, J., & Rodríguez-Díaz, J. (2016) · Viruses in Foods · doi:10.1007/978-3-319-30723-7_3 · Cited by 18
“2009b ; Kapoor et al.”
BackgroundItarte, M., Martínez-Puchol, S., Forés, E., Hundesa, A., Timoneda, N., Bofill-Mas, S., Girones, R., & Rusiñol, M. (2021) · Foods · doi:10.3390/foods10081820 · Cited by 17
Discovery of novel astrovirus genotype species in small ruminants
Kauer, R., Koch, M., Hierweger, M. M., Werder, S., Boujon, C. L., & Seuberlich, T. (2019) · PeerJ · doi:10.7717/peerj.7338 · Cited by 16
“With an identity of 57% on the amino acid level to BoAstV-CH13, this putative AstV would be part of the so-called human-mink-ovine-like clade, which also comprises the fecal OvAstV-1 strain as well as the vast majority of encephalitis-associated strains in humans and animals (Kapoor et al., 2009; Reuter, Pankovics & B…”
BackgroundWang, F., Wang, Y.-H., Peng, J.-S., Zhou, X., Tang, L., Kobayashi, N., Hu, Q., Zhou, D.-J., Huang, H.-J., & Liu, M.-Q. (2011) · Canadian Journal of Microbiology (print) · doi:10.1139/w11-085 · Cited by 16
Gut virome in early life: origins and implications
Kennedy, E. A., & Holtz, L. R. (2022) · Current Opinion in Virology · doi:10.1016/j.coviro.2022.101233 · Cited by 18
Kour, R., Kumar, P., Jindal, N., Minhas, S. K., Kumar, R., Gupta, A. K., & Malik, A. (2021) · Archives of Virology · doi:10.1007/s00705-021-05195-8 · Cited by 15
Presence of Segmented Flavivirus Infections in North America
Vandegrift, K., Kumar, A., Sharma, H., Murthy, S., Kramer, L., Ostfeld, R., Hudson, P., & Kapoor, A. (2020) · Emerging Infectious Diseases · doi:10.3201/eid2608.190986 · Cited by 15
“To confirm that the FLSV-US genome is segmented, we used FLSV-US reads showing substantial similarity to JMTV NS3 protein for acquiring the 3′ end of FLSV-US NS3 coding segment using a poly-T oligonucleotide-primed cDNA synthesis followed by specific PCR, as previously described (27).”
MethodSelf-citationMartella, V., Moschidou, P., & Buonavoglia, C. (2011) · The Veterinary clinics of North America. Small animal practice · doi:10.1016/j.cvsm.2011.09.001 · Cited by 15
“[23] [24] [25] Antibodies to one such novel AstV, strain MAstV/GII.B/Hu/THA/2001/NE-3010, have been detected in 20% to 36% of the sera of children.”
BackgroundHigh Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations
Janowski, A. B., Owen, M. C., Dudley, H. M., López, T., Espinosa, R., Elvin-Lewis, M. P. F., Colichón, A., Arias, C. F., Burbelo, P. D., & Wang, D. (2021) · mSphere · doi:10.1128/msphere.00484-21 · Cited by 17
Amoroso, M. G., Russo, D., Lanave, G., Cistrone, L., Pratelli, A., Martella, V., Galiero, G., Decaro, N., & Fusco, G. (2018) · Zoonoses and Public Health · doi:10.1111/zph.12484 · Cited by 14
“Recently, AstVs have been also detected in the nervous tissues of minks with shaking disease (Blomstrom, Widen, Hammer, Belak, & Berg, 2010) and of bovines with neurological disorders (Bouzalas et al., 2014; Li et al., 2013).”
InfluentialMelamed, R., Storch, G., Holtz, L. R., Klein, E., Herrin, B. E., Tarr, P., & Denno, D. (2017) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piw083 · Cited by 14
Leblanc, D., Inglis, G., Boras, V. F., Brassard, J., & Houde, A. (2016) · Archives of Virology · doi:10.1007/s00705-016-3063-9 · Cited by 14
Cordey, S., Brito, F., Vu, D., Turin, L., Kilowoko, M., Kyungu, E., Genton, B., Zdobnov, E., D'Acremont, V., & Kaiser, L. (2016) · Emerging Microbes and Infections · doi:10.1038/emi.2016.67 · Cited by 14
Fernandez-Cassi, X., Rusiñol, M., & Martínez-Puchol, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8682-8_13 · Cited by 14
Composition of Eukaryotic Viruses and Bacteriophages in Individuals with Acute Gastroenteritis
Ramos, E. D. S. F., Ribeiro, G. D. O., Villanova, F., Milagres, F. A. D. P., Brustulin, R., Araújo, E. L. L., Pandey, R. P., Raj, V. S., Deng, X., Delwart, E., et al. (2021) · Viruses · doi:10.3390/v13122365 · Cited by 12
Self-citationGenetic Diversity of Astrovirus in Children From a Birth Cohort in Nepal
Shrestha, S., Shrestha, J., Andreassen, Å., Strand, T., Dudman, S., & Dembinski, J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.588707 · Cited by 13
“Human astrovirus were initially identified and classified into eight serotypes (Kjeldsberg, 1994; Kazushi et al., 2000) and these are estimated to cause about 10% of sporadic diarrhea cases (Kirkwood, 2005).”
BackgroundInfection and propagation of astrovirus VA1 in cell culture
Janowski, A. B., & Wang, D. (2018) · Current Protocols in Microbiology · doi:10.1002/cpmc.73 · Cited by 13
“…human specimens through molecular assays and metagenomic sequencing, including mamastrovirus 6, 8, and 9 (Finkbeiner et al., 2008; Finkbeiner et al., 2009; Finkbeiner et al., 2009; Finkbeiner, Kirkwood, & Wang, 2008; Jiang et al., 2013; Kapoor et al., 2009; Meyer et al., 2015; Phan et al., 2014).”
BackgroundSatapathy, P., Khan, K., Devi, A. T., Patil, A. G., Govindaraju, A. M., Gopal, S., Prasad, M. N. N., More, V. S., Kakarla, R. R., Raghu, A. V., et al. (2019) · Methods in microbiology · doi:10.1016/bs.mim.2019.02.001 · Cited by 17
Prevalence of Astroviruses in Different Animal Species in Poland
Kuczera, K., Orłowska, A., Smreczak, M., Frant, M., Trębas, P., & Rola, J. (2024) · Viruses · doi:10.3390/v16010080 · Cited by 12
“Using phylogenetic tools, a few studies revealed that novel human astroviruses were phylogenetically clustered more closely with animal astroviruses (mink, ovine, and rat) than with human AstVs [12].”
MethodMaximova, O. A., Weller, M. L., Krogmann, T. A., Sturdevant, D. E., Ricklefs, S., Virtaneva, K. I., Martens, C., Wollenberg, K. R., Minai, M., Moore, I. N., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011544 · Cited by 14
“A first round of PCR was performed using primers panAV-F11 (5-GARTTYGATTGGRCKCGKTAYGA-3), panAV-F12 (5-GARTTYGATTGGRCKAGG TAYGA-3) and panAV-R1 (5-GGYTTKACCCACATICCRAA-3), followed by a second round of PCR with primers panAV-F21 (5-CGKTAYGATGGKACKATICC-3), panAV-F22 (5-AGGTAYGATGGKACKATICC-3) and panAV-R1 as previousl…”
Zhou, N., Zhou, L., & Wang, B. (2019) · Viruses · doi:10.3390/v11080707 · Cited by 12
Nijhuis, R., Sidorov, I., Chung, P., Wessels, E., Gulyaeva, A., de Vries, J. D., Claas, E., & Gorbalenya, A. (2018) · Journal of Clinical Virology · doi:10.1016/j.jcv.2018.09.007 · Cited by 12
“Different subsets of these groups were targeted by a range of PCR assays designed in our group [24] and other studies [6,17–23], while a pan-astrovirus assay was also described [16,33] (Fig.”
MethodBirch, J. M., Ullman, K., Struve, T., Agger, J. F. G., Hammer, A. S., Leijon, M., & Jensen, H. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205890 · Cited by 11
“There might also be strains with different pathogenic potential since a huge diversity of astroviruses has been found in other species, including human [40] [41] [42] .”
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“As emerging HAstVs since 2008 (Finkbeiner et al. 2008, 2009), HAstV-MLB and HAstV-VA/ HMO infections in children have been reported in some regions (Kapoor et al. 2009; Jiang et al. 2013; Wang et al. 2013).”
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Rosavirus: the prototype of a proposed new genus of the Picornaviridae family
Phan, T., Nguyen, V. P., Simmonds, P., Samayoa, E., Naccache, S., Chiu, C. Y., & Delwart, E. (2013) · Virus genes · doi:10.1007/s11262-013-0968-1 · Cited by 12
Self-citationEpidemiology of Human Astroviruses
Bosch, A., Guix, S., & Pintó, R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4735-1_1 · Cited by 12
Immunogenicity and Efficacy Evaluation of Subunit Astrovirus Vaccines
Bidokhti, M., Ullman, K., Hammer, A., Jensen, T. H., Chriel, M., Byrareddy, S., & Baule, C. (2019) · Vaccines · doi:10.3390/vaccines7030079 · Cited by 11
“Genomic [59] and proteomic [49,60] studies have shown that conserved non-immunogenic regions are located at N- and C-termini of CP.”
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Lizasoain, A., Tort, L., García, M., Gómez, M. M., Cristina, J., Leite, J. P. G., Miagostovich, M., Victoria, M., & Colina, R. (2015) · Food and Environmnetal Virology · doi:10.1007/s12560-015-9186-4 · Cited by 11
“Keywords Astrovirus Sewage Epidemiology Environment Uruguay Diversity”
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Horigan, S., Kettenburg, G., Kistler, A. L., Ranaivoson, H., Andrianiaina, A. F., Andry, S., Raharinosy, V., Randriambolamanantsoa, T. H., Tato, C., Lacoste, V., et al. (2024) · Virology Journal · doi:10.1186/s12985-024-02471-2 · Cited by 10
“This lack of host specificity demonstrates AstVs’ efficiency in cross-species transmission, thought to be facilitated by high viral diversity and frequent recombination events [16, 18–21].”
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Zaccaria, G., Lorusso, A., Hierweger, M. M., Malatesta, D., Defourny, S. V. P., Ruggeri, F., Camma', C., Ricci, P., Domenico, M. D., Rinaldi, A. M., et al. (2020) · Viruses · doi:10.3390/v12050530 · Cited by 10
“Whole genome sequences representative of the genus Mamastrovirus, including sequences of AstVs connected with neurological disease reports, and of the genus Avastrovirus (as an outgroup rooting) were retrieved from Genbank and aligned with that obtained in this study using the MAFFT system [36].”
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Mombo, I., Suquet, E., Boundenga, L., Mveang-Nzoghe, A., Maganga-Mboga, C., Arnathau, C., Sidobre, C., Leroy, E., & Rougeron, V. (2019) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2018.12.003 · Cited by 10
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Kingsley, D. (2016) · Microbiology spectrum · doi:10.1128/microbiolspec.pfs-0007-2014 · Cited by 10
“A recent metagenomics study has identi fi ed a previously unknown feline astrovirus that is closely related to human astrovirus, suggesting past cross-species infection (141).”
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Examination of a plasmid‐based reverse genetics system for human astrovirus
Chapellier, B., Tange, S., Tasaki, H., Yoshida, K., Zhou, Y., Sakon, N., Katayama, K., & Nakanishi, A. (2015) · Microbiology and immunology · doi:10.1111/1348-0421.12317 · Cited by 10
Lu, L.-J., Zhong, H.-Q., Xu, M.-H., Jia, R., Liu, P.-C., Su, L., Cao, L.-F., Zhu, X.-H., & Xu, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1265843 · Cited by 9
“However, the definitive link between these novel HAstV infections and gastroenteritis remains unestablished due to the limited number of comprehensive epidemiological studies (Finkbeiner et al., 2008a,b, 2009a,b,c; Kapoor et al., 2009).”
BackgroundInfluentialIdentification of a novel protein in porcine astrovirus that is important for virus replication.
Du, Y., Ji, C., Liu, T., Zhang, W., Fang, Q., Dong, Q., Li, M.-Y., Wang, H., Chen, Y., Ouyang, K., et al. (2021) · Veterinary Microbiology · doi:10.1016/j.vetmic.2021.108984 · Cited by 9
Diversity of human astroviruses in Germany 2018 and 2019
Niendorf, S., Marques, A. M., Bock, C., & Jacobsen, S. (2022) · Virology Journal · doi:10.1186/s12985-022-01955-3 · Cited by 8
“HAstV positive samples were further genotyped by a PCR adapted from Kapoor and colleagues [11, 20].”
MethodAstrovirus reverse genetics systems, a story of success.
Sandoval-Jaime, C. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.06.009 · Cited by 8
Bidokhti, M., Ullman, K., Jensen, T. H., Chriel, M., Mottahedin, A., Munir, M., Andersson, A. M., Detournay, O., Hammer, A., & Baule, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082978 · Cited by 8
Astrovirus Infections in Animal Mammalian Species
Cattoli, G., Chu, D. K., & Peiris, M. (2012) · Astrovirus Research · doi:10.1007/978-1-4614-4735-1_8 · Cited by 8
“Genetic sequencing of astroviruses recently led to the detection of viruses in human stool that are genetically closely related to OAstV and mink astrovirus (MiAstV), and has revealed the possibility that these viruses have a common ancestor, as previously suggested also for the HAstVs, feline astroviruses (FAstVs), a…”
BackgroundVimbiso, C., Hélène, D., Malika, A., Getrude, M., Valérie, P., Ngoni, C., Gift, M., Laure, G., Davies, P., Julien, C., et al. (2023) · bioRxiv · doi:10.1101/2023.04.14.536987 · Cited by 7
“Another AstV strain detected in Hipposideros bat species clustered with HuAstv MLB-1, -2 and -3 which are all known to cause gastro-intestinal and neurological diseases with mild-severe symptoms in humans (Kapoor et al., 2009).”
BackgroundSerotype Diversity of Astroviruses in Rawalpindi, Pakistan during 2009–2010
Alam, M., Khurshid, A., Rana, M. S., Shaukat, S., Sharif, S., Angez, M., Naeem, M., & Zaidi, S. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061667 · Cited by 7
“Recently, novel astroviruses designated as AstV-HMO-A and AstV-HMO-B have been identified in Pakistan and Nigeria through metagenomic analysis of pediatric stool samples [14] but none of these new variants have been found in the present study which can be attributed to our use of highly specific primers targeting only…”
BackgroundSelf-citationPathogens for Travelers’ Diarrhea in Nepal and Resistance Patterns
Murphy, H., & Pandey, P. (2012) · Current Infectious Disease Reports · doi:10.1007/s11908-012-0253-9 · Cited by 7
“none of 95 healthy control samples [36].”
BackgroundSelf-citationAn introduction to food- and waterborne viral disease
Cook, N., & Richards, G. (2013) · doi:10.1533/9780857098870.1.3 · Cited by 7
Kachooei, A., Mirhoseinian, M., Jalilvand, S., Latifi, T., Feizi, M., Shahosseini, Z., Arashkia, A., Marashi, S., & Shoja, Z. (2024) · Virus genes · doi:10.1007/s11262-024-02075-6 · Cited by 6
“Moreover, two additional species of highly divergent HAstV, Melbourne (MLB; MAstV-6) and Virginia/Human-Mink-Ovine-like (VA/HMO; MAstV8 and MAstV9), have been recently identified in human stools of individuals with AGE worldwide [19, 20, 33, 36].”
Huang, D.-Y., Wang, Z., Zhang, F.-J., Wang, T., Zhang, G.-Y., & Sai, L. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26995 · Cited by 6
“Since 2008, MLB‐HAstVs and VA‐HAstVs have been discovered one after another from patients with diarrhea and called novel HAstVs.(8,9) The two novel HAstVs contained three and four MLB 1–3 and VA 1–4 genotypes, respectively, and exhibited highly genetically distinct from classical HAstVs.”
BackgroundIdentification of a Type-Specific Epitope in the ORF2 Protein of Duck Astrovirus Type 1
Lan, J., Zhang, R.-H., Li, P.-F., Chen, J., Xie, Z., & Jiang, S.-J. (2019) · Animals · doi:10.3390/ani9121069 · Cited by 6
Waterborne Enteric Viruses: Diversity, Distribution, and Detection
Abbaszadegan, M., & Alum, A. (2015) · ASM Press eBooks · doi:10.1128/9781555818821.ch3.1.5 · Cited by 6
Are an Aging Gut and a Decrease in Butyrate Production the Reasons for Atherosclerosis?
Dicks, L. M. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178276 · Cited by 6
“Less is known about the virome of the human gut, except for pathogenic viruses, such as Enterovirus from the family Picornaviridae [35], and Rotavirus [36] and Norovirus [37], from the families Reoviridae and Caliciviridae , respectively.”
Mouse and human immune responses share neutralization epitopes of HAstV-VA1
Ramírez-Bello, I., López, T., Espinosa, R., Ghosh, A., Green, K., Riaño-Umbarila, L., Gaspar-Castillo, C., Aguilera-Flores, C., Alpuche-Aranda, C., López, S., et al. (2024) · Journal of Virology · doi:10.1128/jvi.00971-24 · Cited by 5
“Beginning in 2008, astrovirus strains, genetically closer to bovine, ovine, and porcine astroviruses rather than to classical HAstVs, were reported in human feces (4–6).”
BackgroundKombila, L. B., N'dilimabaka, N., Garcia, D., Rieu, O., Engone-Ondo, J., Mebaley, T. N., Boundenga, L., Fritz, M., Lenguiya, L. H., Maganga, G., et al. (2023) · Animals · doi:10.3390/ani13152512 · Cited by 5
Mbou-Boutambe, C., Mombo, I. M., Rougeron, V., Degrugillier, F., Gauthier, P., Makanga, B. K., Ngoubangoye, B., Leroy, E. M., Prugnolle, F., & Boundenga, L. (2024) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2024.105607 · Cited by 4
Mombo, I., Boundenga, L., Suquet, E., Ngoubangoye, B., Maganga, G., Leroy, E., Charpentier, M. J. E., & Rougeron, V. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104659 · Cited by 4
Chen, D.-M., Sun, Y., Zhao, L.-Q., Qian, Y., Zhu, R., Liu, L.-Y., Jia, L.-P., Dong, H.-J., Deng, J., & Deng, L. (2014) · doi:10.4172/2161-0665.1000208 · Cited by 4
“Studies have shown that the prevalence of these viruses has increased in recent years, with some of them, previously believed to be rare, causing a wider range of serious diseases [3-6].”
BackgroundOsterhaus, A. D. M. E., & Smits, S. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00097-5 · Cited by 4
“…nucleic acid amplification techniques (Allander et al., 2005; Finkbeiner et al., 2009; Fouchier et al., 2004; Gaynor et al., 2007; Jones et al., 2005; Kapoor et al., 2008b, 2009; Palacios et al., 2008; Smits et al., 2010b; Van der Hoek et al., 2004; Van Leeuwen et al., 2010; Victoria et al., 2008).”
MethodRotaviruses, astroviruses, and sapoviruses as foodborne infections
Mattison, C. P., Vinjé, J., Parashar, U., & Hall, A. (2021) · Foodborne Infections and Intoxications · doi:10.1016/b978-0-12-819519-2.00033-5 · Cited by 4
Molecular Epidemiology of Astroviruses
Khamrin, P., Maneekarn, N., & Ushijima, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802241-2.00024-9 · Cited by 4
[First detection of human astrovirus in gastroenteritis outbreak in Hungary].
Pankovics, P., Boros, Á., Rovács, M., Nagy, E., Krisztián, E., Vollain, M., & Reuter, G. (2011) · Orvosi Hetilap · doi:10.1556/oh.2011.29013 · Cited by 4
Kumar, P., Panghal, R., Minhas, S. K., Yadav, R., Mehtani, R., Kumar, V., Lather, A., Raj, S., Wani, M., Kattoor, J. J., et al. (2026) · Archives of Virology · doi:10.1007/s00705-026-06535-2 · Cited by 3
“The generic primers that reportedly amplify the conserved region of the RdRp gene fragment [43] have been used for the detection of AstVs in various animal species, including humans, cheetahs, bats, rodents, shrews, weasels, bovines, and birds [44, 49, 82, 109–112].”
Wang, J., Liu, B., Liu, S.-S., Sun, Y.-W., He, R., Lan, Y., Liu, L.-N., & Jiang, H. (2025) · Microbiology spectrum · doi:10.1128/spectrum.00836-25 · Cited by 3
Exploring the Astrovirome of Shellfish Matrices Using Nanopore Sequencing
Beikpour, F., Pellegrini, F., Lanave, G., Camero, M., Catella, C., Martino, B. D., Profio, F. D., Masotti, C., Battistini, R., Serracca, L., et al. (2023) · Veterinary Sciences · doi:10.3390/vetsci10030175 · Cited by 3
ENTERIC VIRAL ZOONOSES: COUNTERACTING THROUGH ONE HEALTH APPROACH
Verma, A., Bhat, S., Sircar, S., Dhama, K., & Malik, Y. (2018) · Journal of Experimental Biology and Agricultural Sciences · doi:10.18006/2018.6(1).42.52 · Cited by 3
“The mammalian viruses are often associated with gastroenteritis in most mammalian species, whereas the avian strains are known to cause both intestinal and extra-intestinal diseases (Kapoor et al., 2009), although economic losses due to reduced growth rate and productivity are yet to be established.”
BackgroundProduction of polyclonal antibody to a recombinant non-structural protein Nsp1a of human astrovirus.
Liu, C., Liu, W.-H., Kan, L.-L., Li, X., Li, Y.-G., & Zhao, W. (2014) · Journal of Virological Methods · doi:10.1016/j.jviromet.2014.09.007 · Cited by 3
“However, several divergent new astroviruses MLB1/MLB2, VA1/VA2/VA3, and HMO A/B/C) were recently disovered in stool samples from patients with diarrhea (Finkbeiner t al., 2008a,b, 2009a,b,c; Kapoor et al., 2009) and without diarrhea Walter et al.”
BackgroundDakouo, D., Ouattara, A. K., Ouermi, D., Traoré, M. A. E., Zohoncon, T. M., Sawadogo, M., Zigani, N. L., Tao, N. I., Traore, L., Ouedraogo, T. C., et al. (2024) · American Journal of Molecular Biology · doi:10.4236/ajmb.2024.144016 · Cited by 3
Astroviruses as Foodborne Infections
Karlsson, E., & Schultz-Cherry, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416041-5.00020-2 · Cited by 3
Isolation and preliminary pathogenicity of a recent feline astrovirus strain in China
Wang, W., Zhang, Y., Wang, X.-X., Zhu, X., Gong, L., Jing, Z., Meng, T., Shen, J., Tan, Y.-P., Qin, T., et al. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1614686 · Cited by 2
“Moreover, FeAstV has been reported in children with diarrhea, suggesting the potential possibility of FeAstV infecting humans (3).”
Nokhova, A., Dubovitskiy, N., Derko, A., Khozyainova, A., Kurskaya, O., Shestopalov, A., & Sharshov, K. (2025) · Acta virologica · doi:10.3389/av.2025.13512 · Cited by 2
“To assemble according to the reference, the contigs of AVs were mapped against the nr/nt database using BLAST to obtain the closest full genomic (or complete CDS) sequence, followed by consensus building from the libraries using BWA-MEM (Li and Durbin, 2009), SAMtools (Li et al., 2009).”
Ijeomah, I. M., Temitope, F. O. C., Lander, D., Sheriff, A., Uwem, G. E., Bernard, O. A., Oluseyi, O., Elijah, O. I., Toluwani, A. G., Arthur, O. O., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29489 · Cited by 2
“12,17,18 The nonclassical HAstVs including the HAstV ‐ MLB ‐ 1 and HMO species A and B have also been reported in Nigeria.”
BackgroundMetagenomics applied to the detection of diarrhea viruses in humans: Systematic Review.
David, E. D. S., Fonseca, E. D. C., de Carvalho, J. F. D., Marinho, R. D. S. S., Duro, R., Komninakis, S., & Souto, R. N. P. (2021) · Acta Tropica · doi:10.1016/j.actatropica.2021.106287 · Cited by 2
Circulation of classic and recombinant human astroviruses detected in South Africa: 2009 to 2014.
Nadan, S., Taylor, M. B., & Page, N. (2020) · Journal of Clinical Virology · doi:10.1016/j.jcv.2020.104719 · Cited by 2
Zhao, W., Tao, X.-L., Liu, N.-Q., Lu, H., Zheng, C.-H., Li, X.-Y., Yu, M., & Li, Y.-G. (2019) · Journal of General Virology · doi:10.1099/jgv.0.001231 · Cited by 2
RetractedGenomics and Foodborne Viral Infections
Smits, S., & Koopmans, M. (2017) · Applied Genomics of Foodborne Pathogens · doi:10.1007/978-3-319-43751-4_9 · Cited by 2
“Many previously unknown viruses have been characterized in human stool in recent years including sali-, cosa-, bufa-, picobirna-, reco-, anello-, hepatitis E, astro-, and polyomaviruses of which the clinical disease spectrum, route of transmission, and foodborne nature remains to be elucidated [36] [37] [38] [39] [40]…”
BackgroundFinkbeiner, S. R., & Holtz, L. R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4735-1_7
“AstV-VA2/HMOAStV-A has also been detected in stools from the United States, Egypt, India, and Nigeria [ 1, 13, 27 ] .”
BackgroundInfluentialAetiological importance of viruses causing acute gastroenteritis in humans
Higgins, G., Schepetiuk, S., & Ratcliff, R. (2012) · Microbiology Australia · doi:10.1071/ma12049 · Cited by 2
Genomic characterization of a novel human astrovirus MLB1 variant from Tanzania.
Shayo, M. J., Kuchaka, D., Beti, M., Mwing'a, G., Kimu, P., Wadugu, B. D., Juma, M. A., Kumburu, H. H., Kiwelu, I., Ali, M., et al. (2026) · Virology · doi:10.1016/j.virol.2026.110861 · Cited by 1
Horigan, S., Kistler, A., Ranaivoson, H., Andrianianina, A., Andry, S., Kettenburg, G., Raharinosy, V., Randriambolamanantsoa, T. H., Tato, C., Lacoste, V., et al. (2023) · bioRxiv · doi:10.1101/2023.10.27.564436 · Cited by 1
“This lack of host specificity demonstrates AstVs’ efficiency in cross-species transmission, thought to be facilitated by high viral diversity and frequent recombination events 16,18–21 .”
BackgroundZhang, F.-F., Chase-Topping, M., Guo, C.-G., & Woolhouse, M. (2021) · bioRxiv · doi:10.1101/2021.09.13.460031 · Cited by 1
Red fox viromes across an urban-rural gradientPreprint
Campbell, S. J., Ashley, W., Gil-Fernández, M., Newsome, T., Giallonardo, F. D., Ortiz-Baez, A., Mahar, J., Towerton, A. L., Gillings, M., Holmes, E., et al. (2020) · bioRxiv · doi:10.1101/2020.06.15.153858 · Cited by 1
Nduwimana, C., Odari, E., Nyangao, J., Sang, C., & Lihana, R. W. (2019) · Journal of Biology Agriculture and Healthcare · doi:10.7176/jbah/9-10-04 · Cited by 1
“It is one of the principal causes of morbidity and mortality among children in developing countries where numerous cases occur without identification of the specific etiologic agents (Kapoor et al., 2009).”
BackgroundAstroviruses-Emerging Neurotropic Pathogens.
Wang, D. (2016) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piv058 · Cited by 1
Burd, E. M., & Hinrichs, B. H. (2015) · Molecular Pathology in Clinical Practice · doi:10.1007/978-3-319-19674-9_50 · Cited by 1
The Effects of the Gut Microbiota on the Host Chromatin Landscape
Semenkovich, N. P. (2017) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k77m06c1 · Cited by 1
Meng, F.-R., Li, R., Ding, L.-Y., Wang, Z., Liu, X., Song, Y.-C., Lang, F., Yang, L.-Y., & Cheng, Z.-Q. (2026) · Veterinary Research · doi:10.1186/s13567-025-01667-w
“Since its initial isolation from the feces of infants with diarrhea in 1975 [1], AstV has expanded its host range to include both mammals and avian species [2].”
Geographic and cross-species transmission of Mamastroviruses from multiple hosts
Wang, Y., Wu, H., Liu, X.-B., Ma, H., Li, A., Li, Y.-D., & Guo, X. (2026) · Animal Microbiome · doi:10.1186/s42523-026-00517-0
“In humans, human astroviruses (HuAstVs) primarily cause gastroenteritis in children, the elderly, and immunocompromised individuals [2], but have also been detected in patients with fatal meningoencephalitis [4], acute flaccid paralysis [5], and respiratory infections [6].”
Astroviruses and celiac disease: a preliminary study into potential environmental triggers
Polat, C., Şahin, T., Şimşek, C., Tekin, İ. E., İsrafilov, S., Sökmensüer, C., Şimşek, H., Balaban, H., & Ergünay, K. (2025) · Acta medica · doi:10.32552/2025.actamedica.1094
“…single-stranded RNA viruses have three genotypes/species were described; classic (HAstV-1–8, Mamastrovirus hominis ), MLB (Melbourne) (MLB1-3, Mamastrovirus melbournense ) and VA/HMO (Virginia/Human‐ Mink‐Ovine‐like) (VA1-5, Mamastrovirus homustovis and Mamastrovirus virginiaense ) [14-20].”
Rouamba, S. S., Tapsoba, F., Kaboré, B., Soubeiga, A., Bande, M., Kabré, E., & Savadogo, A. (2024) · Food and Environmnetal Virology · doi:10.1007/s12560-024-09621-3
“The possible zoonotic transmission of astroviruses from cows has recently been reported (Kapoor et al., 2009).”
Kébé, O., Thiaw, F., Ndiaye, N., Landoh, D. E., Cissé, G., Faye, O., & Faye, M. (2023) · Microbiology Resource Announcements · doi:10.1128/mra.00214-23
Maximova, O., Weller, M., Krogmann, T., Sturdevant, D., Ricklefs, S., Virtaneva, K., Martens, C., Wollenberg, K., Minai, M., Moore, I. N., et al. (2022) · bioRxiv · doi:10.1101/2022.08.20.504643
Detection of Novel Human Astrovirus MLB1 by a Commercial Viral Gastroenteritis Multiplex Assay
Ho, Y. I., Lee, C. W., & Wong, A. (2022) · Microbiology spectrum · doi:10.1128/spectrum.00469-22
“Novel HAstV types are phylogenetically more closely related to animal astroviruses than to HAstV-C, suggesting cross-species transmission (3).”
BackgroundReuter, G., & Knowles, N. (2019) · Diseases of Swine · doi:10.1002/9781119350927.ch27
[Natural reservoirs of viruses of the genus Hepacivirus, Flaviviridae].
Deriabin, P. G. (2016) · Voprosy virusologii · doi:10.18821/0507-4088-2016-61-3-101-106
Calistri, A., & Palù, G. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu913
Novel human astroviruses (HAstVs) identified recently
Liu, M.-Q. (2014) · doi:10.5897/ajmr2014.6739
“HMOAstV/AstV-VA was another novel astrovirus species identified from human stool (Kapoor et al., 2009; Burbelo et al., 2011).”
BackgroundInfluentialEmerging Trend of Astroviruses, Enteric Adenoviruses, and Rotaviruses in Human Viral Gastroenteritis
Cowley, D., Donato, C., & Kirkwood, C. (2013) · doi:10.1002/9781118297469.ch27
Mozhgani, S., Faghihloo, E., Makvandi, M., Samarbaf-Zadeh, A., Zareh-Khoshchehreh, R., Ajorloo, M., Mousavi-Nasab, S., & Borhani, K. (2012) · doi:10.21859/isv.6.3.30
“All eight known human astrovirus serotypes belonging to the first identified human astrovirus species (HAstV) (6).”
Background
Metadata
- Authors
- Kapoor, A., Li, L., Victoria, J., Oderinde, B., Mason, C., Pandey, P., Zaidi, S. Z., & Delwart, E.
- Affiliations
- University of California, San Francisco (US)
- University of Maiduguri (NG)
- Armed Forces Research Institute of Medical Science (TH)
- CIWEC Clinic Travel Medicine Center, Kathmandu, Nepal
- National Institute of Health (PK)
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2009-12-01
- Volume
- 90
- Issue
- 12
- Pages
- 2965-2972
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- PMC
- PMC2796194
- OpenAlex
- W2114025285
- Cited by
- 241
- References
- 33
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 13 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 17 · 2017: 17 · 2016: 17 · 2015: 17 · 2014: 14 · 2013: 22 · 2012: 23
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of General Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Blood Systems Research Institute
- National Heart, Lung, and Blood Institute (R01HL083254)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- human astrovirus, zoonotic transmission, viral emergence, viral genome, phylogenetic analysis, gastroenteritis
- MeSH terms
- Animals, Mamastrovirus, Diarrhea, Feces, Gastroenteritis, Humans, Molecular Sequence Data, Phylogeny, Species Specificity, Sequence Analysis, DNA, Astroviridae Infections
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