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Multiple novel astrovirus species in human stool
Open accessAbstract
Diarrhoea remains a significant cause of morbidity and mortality in developing countries where numerous cases remain without identified aetiology. Astroviruses are a recently identified cause of animal gastroenteritis which currently includes two species suspected of causing human diarrhoea. Using pan-astrovirus RT-PCR, we analysed human stool samples from different continents for astrovirus-related RNA sequences. We identified variants of the two known human astrovirus species plus, based on genetic distance criteria, three novel astrovirus species all distantly related to mink and ovine astroviruses, which we provisionally named HMOAstV species A–C. The complete genome of species A displayed all the conserved characteristics of mammalian astroviruses. Each of the now three groups of astroviruses found in human stool (HAstV, AstV-MLB and HMOAstV) were more closely related to animal astroviruses than to each other, indicating that human astroviruses may periodically emerge from zoonotic transmissions. Based on the pathogenic impact of their closest phylogenetic relatives in animals, further investigations of the role of HMOAstV, so far detected in Nigeria, Nepal and Pakistan, in human gastroenteritis are warranted.
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“Some human astroviruses are more closely related to those in animals than to each other, suggesting that these viruses periodically emerge from zoonotic origins (Kapoor et al. 2009).”
From Red fox viromes in urban and rural landscapes (2020) · cites this paper as Kapoor et al. 2009
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Research works printed but not linked: 34
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De Benedictis, P., Schultz-Cherry, S., Burnham, A., & Cattoli, G. (2011) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2011.07.024 · Cited by 479
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BackgroundInfluentialGoing viral: next-generation sequencing applied to phage populations in the human gut
Reyes, A., Semenkovich, N. P., Whiteson, K., Rohwer, F. L., & Gordon, J. I. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2853 · Cited by 449
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“The translated amino acid sequence most closely matched the serine protease region of the newly characterized human HMOAstV-A viral genome (34% similarity) (16, 23).”
BackgroundSelf-citationThe Fecal Viral Flora of Wild Rodents
Phan, T., Kapusinszky, B., Wang, C., Rose, R. K., Lipton, H., & Delwart, E. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002218 · Cited by 363
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BackgroundMethodInfluentialSelf-citationThe Fecal Virome of Pigs on a High-Density Farm
Shan, T., Li, L., Peter Simmonds, K., Wang, C., Moeser, A. J., & Delwart, E. (2011) · Journal of Virology · doi:10.1128/jvi.05217-11 · Cited by 347
“The detection of multiple astrovirus species in pigs as well as humans may reflect multiple past cross-species transmissions from other animal sources followed by adaptation to new hosts (40, 41, 57).”
BackgroundSelf-citationVirus hazards from food, water and other contaminated environments
Rodrı́guez-Làzaro, D., Cook, N., Ruggeri, F. M., Sellwood, J., Nasser, A. M., Nascimento, M. S. J., D’Agostino, M., Santos, R., Sáiz, J., Rzeżutka, A., et al. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00306.x · Cited by 330
“Recently, the possible zoonotic transmission of astroviruses from cows was proposed (Kapoor et al., 2009).”
Bosch, A., Pintó, R., & Guix, S. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-14 · Cited by 311
“Some of these nonclassic HAstVs have been shown to have common ancestors with recently described rat AstV (11), while others are phylogenetically related to mink and ovine AstVs (29).”
BackgroundInfluentialCharacterization of a canine homolog of hepatitis C virus
Kapoor, A., Simmonds, P., Gerold, G., Qaisar, N., Jain, K., Henriquez, J. A., Firth, C., Hirschberg, D., Rice, C., Shields, S., et al. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1101794108 · Cited by 295
Self-citationNaccache, S. N., Peggs, K. S., Mattes, F. M., Phadke, R., Garson, J. A., Grant, P., Samayoa, E., Federman, S., Miller, S., Lunn, M. P., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu912 · Cited by 294
“rhea in children [4, 5]; 95% identity to HAstV-SG, detected in brain tissue from a boy with X-linked agammaglobulinemia and fatal encephalitis [6]; and 52%–54% identity to AstVs linked to”
BackgroundHigh Variety of Known and New RNA and DNA Viruses of Diverse Origins in Untreated Sewage
Ng, T. F. F., Marine, R. L., Wang, C., Peter Simmonds, K., Kapusinszky, B., Bodhidatta, L., Oderinde, B. S., Wommack, K. E., & Delwart, E. (2012) · Journal of Virology · doi:10.1128/jvi.00869-12 · Cited by 279
Self-citationSerology-Enabled Discovery of Genetically Diverse Hepaciviruses in a New Host
Burbelo, P., Dubovi, E., Simmonds, P., Medina, J., Henriquez, J. A., Mishra, N., Wagner, J. C., Tokarz, R., Cullen, J., Iadarola, M., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00250-12 · Cited by 250
Self-citationChiu, C. Y. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.05.001 · Cited by 247
“This approach was recently used to identify novel paramyxoviruses in samples from large-scale surveys of bats and rodents [20–22] and emerging viruses such as coronavirus EMC, the cause of a new severe and occasionally fatal respiratory disease in the Middle East and Europe [6], although many other examples of this st…”
MethodAstrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients
Brown, J. R., Morfopoulou, S., Hubb, J., Emmett, W., Ip, W., Shah, D., Brooks, T., Paine, S., Anderson, G., Virasami, A., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu940 · Cited by 207
“astrovirus heminested PCR assay was carried out as described previously [10].”
BackgroundMethodResultHuman stool contains a previously unrecognized diversity of novel astroviruses
Finkbeiner, S. R., Holtz, L. R., Jiang, Y., Rajendran, P., Franz, C., Zhao, G., Kang, G., & Wang, D. (2009) · Virology Journal · doi:10.1186/1743-422x-6-161 · Cited by 195
The Broad Host Range and Genetic Diversity of Mammalian and Avian Astroviruses
Donato, C., & Vijaykrishna, D. (2017) · Viruses · doi:10.3390/v9050102 · Cited by 196
“Whilst primarily associated with asymptomatic or diarrheal disease in humans, there are several reports of central nervous system (CNS) complications such as acute flaccid paralysis [9], meningitis, and encephalitis [10,11].”
BackgroundInfluentialAstrovirus Biology and Pathogenesis.
Cortez, V., Meliopoulos, V. A., Karlsson, E., Hargest, V., Johnson, C. N., & Schultz-Cherry, S. (2017) · Annual Review of Virology · doi:10.1146/annurev-virology-101416-041742 · Cited by 194
Epidemiology of Classic and Novel Human Astrovirus: Gastroenteritis and Beyond
Vu, D., Bosch, A., Pintó, R., & Guix, S. (2017) · Viruses · doi:10.3390/v9020033 · Cited by 184
“Nepal (2006–2008) Adults, negative for bacteria, rotavirus, adenovirus, HAstV, Giardia, Cryptosporidium or norovirus RT-PCR 0 1 [14] *”
BackgroundInfluentialFaecal virome of cats in an animal shelter
Zhang, W., Li, L., Deng, X., Kapusinszky, B., Pesavento, P. A., & Delwart, E. (2014) · Journal of General Virology · doi:10.1099/vir.0.069674-0 · Cited by 215
“Not all astroviruses infecting a given animal host species phylogenetically cluster together, leading to the conclusion that astrovirus cross-species transmission occurs frequently (De Benedictis et al., 2011; Finkbeiner et al., 2009; Kapoor et al., 2009).”
BackgroundSelf-citationDivergent Astrovirus Associated with Neurologic Disease in Cattle
Li, L.-L., Diab, S., McGraw, S., Barr, B., Traslavina, R., Higgins, R., Talbot, T., Blanchard, P., Rimoldi, G., Fahsbender, E., et al. (2013) · Emerging Infectious Diseases · doi:10.3201/eid1909.130682 · Cited by 166
“One study demonstrated an HAstV-PS, which is distinct from the original HAstV and closely related to astrovirus HMO-C (AstV-HMO-C) and HAstV-VA1) (7,8) in the brain tissue of a 15-year-old boy with X-linked agammaglobulinemia who had encephalitis.”
BackgroundSelf-citationThe challenge of diagnostic metagenomics
Greninger, A. L. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1487292 · Cited by 156
Metagenomics for the study of viruses in urban sewage as a tool for public health surveillance
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“More precisely, the application of NGS techniques has facilitated the detection of these later mentioned animal recombinant astroviruses (Finkbeiner et al., 2009; Kapoor et al., 2009), which are related to neurological disorders in immunocompromised patients (Brown et al., 2015).”
BackgroundEmerging View of the Human Virome
Wylie, K., Weinstock, G., & Storch, G. (2012) · Translational Research: The Journal of Laboratory and Clinical Medicine · doi:10.1016/j.trsl.2012.03.006 · Cited by 145
“In recent years, many novel eukaryotic viruses have been discovered or characterized using sequencing, including viruses in the following groups: arenaviruses, 48 astroviruses, 46, 49, 50 rhinoviruses, 51 nodoviruses, 25 coronaviruses, 20 polyomaviruses, 52,53 bocaviruses, 54 enteroviruses, 55 and klasseviruses, 56 am…”
BackgroundComparing viral metagenomics methods using a highly multiplexed human viral pathogens reagent
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Self-citationAcute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus
Phan, T., Vo, N., Bonkoungou, I., Kapoor, A., Barro, N., O'Ryan, M., Kapusinszky, B., Wang, C.-L., & Delwart, E. (2012) · Journal of Virology · doi:10.1128/jvi.01427-12 · Cited by 137
“Metagenomic analyses of human fecal samples have shownfrequent coinfections with known enteric pathogens (26, 70) and the presence of numerous novel viral species, particularly members of the Picornaviridae (20, 31, 33, 37, 40, 51), Astroviridae (26, 27, 41) Parvoviridae (39, 45), and Circoviridae (49, 58) families of…”
BackgroundSelf-citationAstrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection
Cordey, S., Vu, D., Schibler, M., L'Huillier, A., Brito, F., Docquier, M., Posfay-Barbe, K., Petty, T., Turin, L., Zdobnov, E., et al. (2016) · Emerging Infectious Diseases · doi:10.3201/eid2205.151807 · Cited by 133
“Although HAstV-MLB has been recovered from fecal samples of patients with acute flaccid paralysis (6), to our knowledge, no reports have documented this variant in cerebrospinal fluid (CSF) or central nervous system (CNS) tissue samples.”
BackgroundA decade of RNA virus metagenomics is (not) enough
Greninger, A. L. (2017) · Virus Research · doi:10.1016/j.virusres.2017.10.014 · Cited by 138
Nearly Constant Shedding of Diverse Enteric Viruses by Two Healthy Infants
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“The association of the recently characterized human astrovirus-HMO-B (similar to AstV-VA3) (18, 37) with enteric symptoms and its duration of shedding is still uncertain.”
BackgroundSelf-citationAstrovirus evolution and emergence
Wohlgemuth, N., Honce, R., & Schultz-Cherry, S. (2019) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2019.01.009 · Cited by 119
“HAstV-MLB (strains 1–3) and HAstV-VA (stains 1–5) have been further divided into several genotypes (Bosch et al., 2014; Meyer et al., 2015; Phan et al., 2014).”
BackgroundInfluentialBodewes, R., van der Giessen, J., Haagmans, B. L., Osterhaus, A. D. M. E., & Smits, S. L. (2013) · Journal of Virology · doi:10.1128/jvi.00568-13 · Cited by 117
Multiple novel and prevalent astroviruses in pigs
Luo, Z., Roi, S., Dastor, M., Gallice, E., Laurin, M., & L'Homme, Y. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2010.11.026 · Cited by 116
“However, it is w clear that multiple AstV lineages can infect the same imal species and there is also growing evidence that tVs can cross the species barrier (Chu et al., 2008; Zhu al., 2009; Kapoor et al., 2009).”
BackgroundInfluentialNeurotropic Astrovirus in Cattle with Nonsuppurative Encephalitis in Europe
Bouzalas, I., Wüthrich, D., Walland, J., Drögemüller, C., Zurbriggen, A., Vandevelde, M., Oevermann, A., Bruggmann, R., & Seuberlich, T. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01195-14 · Cited by 110
“With the development of tools for pathogen discovery, previously unknown astroviruses such as HuAstV-MLB (28), HuAstV-VA1 (29), and human-mink-ovine-like astrovirus (HMO-AstV) (30) have been identified.”
MethodDetection of novel astroviruses in urban brown rats and previously known astroviruses in humans
Chu, D., Chin, A. W. H., Smith, G. J. D., Chan, K., Guan, Y., Peiris, J. M. M., & Poon, L. (2010) · Journal of General Virology · doi:10.1099/vir.0.022764-0 · Cited by 102
“, 2009a, c) and HMO astroviruses (Kapoor et al., 2009), none of these The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are HM450380–HM450386.”
BackgroundInfluentialJohnson, C. N., Hargest, V., Cortez, V., Meliopoulos, V. A., & Schultz-Cherry, S. (2017) · Viruses · doi:10.3390/v9010022 · Cited by 96
“The HAstV‐VA1–VA3 viruses were first discovered in an outbreak of gastroenteritis in Virginia, USA [44,45]; HAstV‐VA4 in a cohort of Indian children with diarrhea [43]; and HAstV‐VA5 in a cohort in Gambia [46].”
BackgroundInfluentialNovel human astroviruses: Novel human diseases?
Vu, D., Cordey, S., Brito, F., & Kaiser, L. (2016) · Journal of Clinical Virology · doi:10.1016/j.jcv.2016.07.004 · Cited by 95
A novel astrovirus associated with encephalitis and ganglionitis in domestic sheep
Pfaff, F., Schlottau, K., Scholes, S., Courtenay, A., Hoffmann, B., Höper, D., & Beer, M. (2017) · Transboundary and Emerging Diseases · doi:10.1111/tbed.12623 · Cited by 87
“The Mamastrovirus cluster was further divided into genogroup I, containing classical strains, and genogroup II, encompassing the humanmink-ovine (HMO) strain complex (Kapoor et al., 2009) as well as the BoAstV CH13/NeuroS1 strains (Bouzalas et al.”
BackgroundViruses Causing Gastroenteritis: The Known, The New and Those Beyond
Munnink, B. O., & van der Hoek, L. (2016) · Viruses · doi:10.3390/v8020042 · Cited by 87
“The first clade consists of the VA-1, VA-2, VA-3, VA-4, and VA-5 astroviruses, which are genetically related to feline and porcine astroviruses, while the second clade consists of the MLB1, MLB2 and MLB3 astroviruses and form a separate cluster [55, 57, [74] [75] [76] [77] [78] .”
BackgroundBurbelo, P. D., Lebovitz, E. E., & Notkins, A. L. (2014) · Translational research · doi:10.1016/j.trsl.2014.08.006 · Cited by 89
Use of Nucleotide Composition Analysis To Infer Hosts for Three Novel Picorna-Like Viruses
Kapoor, A., Simmonds, P., Lipkin, W., Zaidi, S. S., & Delwart, E. (2010) · Journal of Virology · doi:10.1128/jvi.00601-10 · Cited by 87
“Stools are known to contain viruses that infect host cells and/or bacteriophages, as well as viruses of dietary origins from consumed plants, insects, and animals (3, 4, 16, 17, 27, 36, 38).”
BackgroundSelf-citationBoros, Á., Albert, M., Pankovics, P., Bíró, H., Pesavento, P., Phan, T., Delwart, E., & Reuter, G. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2312.170804 · Cited by 83
“We identified the conserved proteolytic cleavage site (V561HQ ̄TNT) of serine protease (ORF1a) and the conserved Y358GDD motif of the RdRp (ORF1b) (33).”
BackgroundSelf-citationJiang, H.-B., Holtz, L. R., Bauer, I. K., Franz, C. J., Zhao, G.-Y., Bodhidatta, L., Shrestha, S., Kang, G., & Wang, D. (2012) · Virology · doi:10.1016/j.virol.2012.09.040 · Cited by 83
“VA2 and VA3 were identified in a cohort of children with diarrhea in India (Finkbeiner et al., 2009a); HMO-A, B, ll rights reserved. icrobiology and Pathology & icine 660 S. Euclid Ave. St. Wang). and C were simultaneously described in stools from Nigeria, Pakistan and Nepal (Kapoor et al., 2009).”
BackgroundBurbelo, P., Ching, K. H., Esper, F. L., Iadarola, M., Delwart, E., Lipkin, W., & Kapoor, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022576 · Cited by 79
“In addition, a new group of astroviruses, provisionally named HMOAstV/AstV-VA, were discovered by consensus PCR using stool samples from different continents [13,18].”
BackgroundMethodInfluentialSelf-citationLum, S., Turner, A., Guiver, M., Bonney, D., Martland, T., Davies, E., Newbould, M., Brown, J. R., Morfopoulou, S., Breuer, J., et al. (2016) · Transplant Infectious Disease · doi:10.1111/tid.12607 · Cited by 78
“Because t(10;11) is associated with a high risk of disease relapse, she had a fully human leukocyte antigenmatched unrelated donor bone marrow transplant in first remission at 8 months old.”
BackgroundMethodDufková, L., Ščigalková, I., Moutelíková, R., Malenovská, H., & Prodělalová, J. (2012) · Archives of Virology · doi:10.1007/s00705-012-1528-z · Cited by 77
“A close genetic relationship or interspecies transmission of different viruses in the SaV, AstV, and KoV genera has been documented [16, 18, 24, 30].”
BackgroundIdentification of a novel astrovirus in a domestic pig in Hungary
Reuter, G., Pankovics, P., & Boros, Á. (2010) · Archives of Virology · doi:10.1007/s00705-010-0827-5 · Cited by 67
“Interestingly, multiple lineages of astroviruses have been identified in humans (classical HAstV, HAstV-MLB and HMOAstV), phylogenetically separated by different lineages of animal astroviruses [8].”
BackgroundInfluentialIntra- and Cross-Species Transmission of Astroviruses
Roach, S. N., & Langlois, R. (2021) · Viruses · doi:10.3390/v13061127 · Cited by 64
“The human, mink, ovine-like (HMO) AstVs that infect humans (Table 1) are more closely related to mink and ovine viruses (40–45% ORF2 amino acid identity) than the classical HAstVs (23–25% ORF2 amino acid identity) [58], suggesting these viruses emerged from these animal reservoirs after close interactions with humans.”
BackgroundDelwart, E. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.012 · Cited by 59
Self-citationAstrovirus MLB1 Is Not Associated with Diarrhea in a Cohort of Indian Children
Holtz, L. R., Bauer, I. K., Rajendran, P., Kang, G., & Wang, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028647 · Cited by 63
“Subsequently, it has been found in stools collected from around the world [9,11,12,13,14,15] from patients with and without diarrhea.”
BackgroundEvidence of a Recombinant Wild-Type Human Astrovirus Strain from a Kenyan Child with Gastroenteritis
Wolfaardt, M., Kiulia, N., Mwenda, J., & Taylor, M. B. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01093-10 · Cited by 63
“(12) and the occurrence of HAstV recombinants may have a”
BackgroundDetection and genetic characterization of a novel pig astrovirus: relationship to other astroviruses
Laurin, M., Dastor, M., & L'Homme, Y. (2011) · Archives of Virology · doi:10.1007/s00705-011-1088-7 · Cited by 57
“In addition, a number of genetically distinct strains of HuAstV have recently been identified, characterized and proposed to represent novel AstV species based on genetic distance criteria [8, 15].”
BackgroundMolecular characterization of a porcine astrovirus strain in China
Lan, D.-L., Ji, W., Shan, T., Cui, L., Yang, Z.-B., Yuan, C.-L., & Hua, X.-G. (2011) · Archives of Virology · doi:10.1007/s00705-011-1050-8 · Cited by 57
“It has even been found in equine rhinoviruses, coronaviruses, and dog noroviruses [4, 12].”
BackgroundAstrovirus as a possible cause of congenital tremor type AII in piglets?
Blomström, A., Ley, C., & Jacobson, M. (2014) · Acta Veterinaria Scandinavica · doi:10.1186/s13028-014-0082-y · Cited by 56
“The samples were screened for the presence of AstV by a nested pan-AstV PCR [17] designed to target a conserved region of the RNA-dependent-RNA polymerase (RdPp) gene that have previously been shown to efficiently identify AstV in humans [18], bats [17] and pigs [19,20].”
MethodNovel goose-origin astrovirus infection in geese: the effect of age at infection
An, D., Zhang, J., Yang, J., Tang, Y., & Diao, Y. (2020) · Poultry Science · doi:10.1016/j.psj.2020.05.041 · Cited by 55
“Ranging from 6,100 to 7,900 nt in length, the genomes of these viruses are arranged in 3 open reading frames (ORF) (ORF1a, ORF1b, and ORF2), as well as a short 50-untranslated region, a 30-untranslated region, and a polyA tail (Kapoor et al., 2009; Wan et al., 2018).”
BackgroundReuter, G., Pankovics, P., & Boros, Á. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00040-18 · Cited by 49
“Finally, the MAstV9 species includes astrovirus clades VA1 (or HMO-C) (23) and VA3 (or HMO-B) (19, 21, 24).”
Identification and characterization of deer astroviruses.
Smits, S., van Leeuwen, M., Kuiken, T., Hammer, A., Simon, J., & Osterhaus, A. (2010) · Journal of General Virology · doi:10.1099/vir.0.024067-0 · Cited by 49
“To determine whether astroviruses are present in the deer faecal samples, a degenerate RT-PCR assay using primers that target conserved motifs in the RdRP gene of diverse astroviruses (Kapoor et al., 2009) was used (Fig.”
MethodResultJaphet, M. O., Famurewa, O., Adesina, O. A., Opaleye, O., Wang, B., Höhne, M., Bock, C., Marques, A. M., & Niendorf, S. (2019) · Journal of Clinical Virology · doi:10.1016/j.jcv.2018.12.004 · Cited by 48
Red fox viromes in urban and rural landscapes
Campbell, S. J., Ashley, W., Gil-Fernandez, M., Newsome, T. M., Di Giallonardo, F., Ortiz-Baez, A. S., Mahar, J. E., Towerton, A. L., Gillings, M., Holmes, E. C., et al. (2020) · Virus Evolution · doi:10.1093/ve/veaa065 · Cited by 47
Šalamúnová, S., Jacková, A., Mandelík, R., Novotný, J., Vlasáková, M., & Vilcek, S. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1640-8 · Cited by 45
Jacobsen, S., Höhne, M., Marques, A. M., Beslmüller, K., Bock, C., & Niendorf, S. (2018) · Journal of Infection · doi:10.1016/j.jinf.2018.02.006 · Cited by 45
Propagation of Astrovirus VA1, a Neurotropic Human Astrovirus, in Cell Culture
Janowski, A. B., Bauer, I. K., Holtz, L. R., & Wang, D. (2017) · Journal of Virology · doi:10.1128/jvi.00740-17 · Cited by 45
Viral hijacking of host caspases: an emerging category of pathogen–host interactions
Connolly, P. F., & Fearnhead, H. O. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.59 · Cited by 44
“They are divided into two genera; the Avastroviridae which infect birds, and the Mamastroviridae which infect mammals.(69) They are the causative agent of some forms of viral gastroenteritis.”
BackgroundPérot, P., Lecuit, M., & Eloit, M. (2017) · Viruses · doi:10.3390/v9010010 · Cited by 43
Martella, V., Moschidou, P., Pinto, P., Catella, C., Desario, C., Larocca, V., Circella, E., Bányai, K., Lavazza, A., Magistrali, C., et al. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1712.110967 · Cited by 43
Bat Astroviruses: Towards Understanding the Transmission Dynamics of a Neglected Virus Family
Fischer, K., dos Reis, V. P., & Balkema-Buschmann, A. (2017) · Viruses · doi:10.3390/v9020034 · Cited by 42
“The majority of the detected astrovirus sequences clustered with classic HAstV, whereas four sequences from Nigeria were most closely related with previously described AstV-MLB1 [66].”
BackgroundInfluentialNew astrovirus in human feces from Burkina Faso
Phan, T., Nordgren, J., Ouermi, D., Simporé, J., Nitiéma, L., Deng, X.-T., & Delwart, E. (2014) · Journal of Clinical Virology · doi:10.1016/j.jcv.2014.03.024 · Cited by 42
“(mamastrovirus 8) was reported in 2009 with strains VA2 [3] and HMO-A [4].”
BackgroundSelf-citationPorcine astrovirus viremia and high genetic variability in pigs on large holdings in Croatia.
Brnić, D., Prpić, J., Keros, T., Roić, B., Starešina, V., & Jemeršić, L. (2013) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.12.027 · Cited by 42
Martella, V., Pinto, P., Tummolo, F., Grazia, S. D., Giammanco, G., Medici, M., Ganesh, B., L'Homme, Y., Farkas, T., Jakab, F., et al. (2014) · Archives of Virology · doi:10.1007/s00705-014-2153-9 · Cited by 40
“A number of unusual HAstVs discovered recently are genetically more closely related to animal AstVs than to ‘‘canonical’’ HAstVs [3, 16, 17, 26, 28, 39].”
BackgroundIdentification of a novel astrovirus in domestic sheep in Hungary
Reuter, G., Pankovics, P., Delwart, E., & Boros, Á. (2011) · Archives of Virology · doi:10.1007/s00705-011-1151-4 · Cited by 40
“Interestingly, multiple lineages of astroviruses have been identified in humans (classical HAstV, HAstV-MLB and HMOAstV), and these are phylogenetically separated by different lineages of animal astroviruses [3, 10].”
BackgroundSelf-citationMajumdar, M., & Martín, J. E.-S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01956 · Cited by 42
Molecular detection of Porcine astrovirus in Sichuan Province, China
Cai, Y.-H., Yin, W., Zhou, Y.-C., Li, B., Ai, L., Pan, M., & Guo, W.-Z. (2016) · Virology Journal · doi:10.1186/s12985-015-0462-6 · Cited by 39
“The fecal samples were initially examined for the presence of PoAstV with a nested pan-PCR [12] designed to target a conserved region of the RNA-dependent RNA polymerase (RdRp) gene, which has been used previously for the sensitive and specific identification of AstV in mammals, including humans [13], pigs [1, 2, 6, 9…”
MethodNovel Astroviruses in Children, Egypt
Ahmed, S. F., Sebeny, P., Klena, J., Pimentel, G., Mansour, A., Naguib, A., Bruton, J., Young, S. Y., Holtz, L. R., & Wang, D. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1712.110909 · Cited by 38
Hata, A., Kitajima, M., Haramoto, E., Lee, S., Ihara, M., Gerba, C., & Tanaka, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-30217-y · Cited by 37
Alam, M., Khurshid, A., Shaukat, S., Rana, M. S., Sharif, S., Angez, M., Nisar, N., Aamir, U. B., Naeem, M., & Zaidi, S. S. (2015) · Viruses · doi:10.3390/v7010378 · Cited by 37
“In humans, eight well-characterized AstV serotypes (HAstV 1–8) have been reported, in addition to the newly identified species, AstV MLB-1 and 2, AstV-VA1, AstV-HMO-A, and AstV-HMO-B [14].”
BackgroundSelf-citationPativada, M., Nataraju, S. M., Ganesh, B., Rajendran, K., Ramamurthy, T., Ganguly, S., Bhattacharya, M., Ghosh, M., Kobayashi, N., & Krishnan, T. (2012) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.07.018 · Cited by 38
“Three novel human astrovirus species (HMOAstV-A-B-C) found in human stool samples showed close genetic relatedness to mink and bovine astroviruses (Kapoor et al., 2009).”
BackgroundHigh evolutionary rate of human astrovirus.
Babkin, I., Tikunov, A., Zhirakovskaia, E., Netesov, S., & Tikunova, N. (2012) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.01.019 · Cited by 37
The Expanding Field of Mammalian Astroviruses: Opportunities and Challenges in Clinical Virology.
Boujon, C. L., Koch, M., & Seuberlich, T. (2017) · Advances in Virus Research · doi:10.1016/bs.aivir.2017.07.002 · Cited by 37
Cordey, S., Brito, F., Vu, D., Turin, L., Kilowoko, M., Kyungu, E., Genton, B., Zdobnov, E., D'Acremont, V., & Kaiser, L. (2016) · Emerging Microbes and Infections · doi:10.1038/emi.2016.98 · Cited by 35
Prevalence and risk factors of astrovirus infection in puppies from French breeding kennels.
Grellet, A., de Battisti, C., Feugier, A., Pantile, M., Marciano, S., Grandjean, D., & Cattoli, G. (2012) · Veterinary Microbiology · doi:10.1016/j.vetmic.2011.11.012 · Cited by 34
Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus
Xavier, M. D. P. T. P., Costa, F. A. C., Rocha, M., de Andrade, J. D. S. R., Diniz, F. B., de Andrade, T. R., Miagostovich, M., Leite, J. P., & Volotão, E. D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135687 · Cited by 33
“The recent identification of novel AstV in humans using highly sensitive methods [9–13], highlights the need to analyze the prevalence of these viruses to recognize their actual impact in public health, since they were found to be genetically related to animal viruses and some were isolated from patients with more sev…”
BackgroundMethodAstrovirus infection in hospitalized children: Molecular, clinical and epidemiological features.
Siqueira, J. A., Oliveira, D. D. S., Carvalho, T. C. D. D., Portal, T. M., Justino, M. C., da Silva, L. D., Resque, H. R., & Gabbay, Y. (2017) · Journal of Clinical Virology · doi:10.1016/j.jcv.2017.07.014 · Cited by 32
The Diversity of Human RNA Viruses
Woolhouse, M. E. J., & Adair, K. (2013) · Future Virology · doi:10.2217/fvl.12.129 · Cited by 42
Hata, A., Katayama, H., Kitajima, M., & Furumai, H. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00563-15 · Cited by 31
“A previous clinical study reported the less frequent detection of MLB-AstV, but the study investigated samples from adults with diarrhea and children without diarrhea (20).”
BackgroundInfluentialDetection of a mammalian-like astrovirus in bird, European roller (Coracias garrulus).
Pankovics, P., Boros, Á., Kiss, T., Delwart, E., & Reuter, G. (2015) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2015.06.020 · Cited by 30
“Astroviruses were screened by RT-PCR using a common screening (Chu et al., 2008; Kapoor et al., 2009) and strain specific (SZAL6A-scr-R: 50-GGCTTTACCCACATACCAAA-30, SZAL6A-scr-F: 50 -GAGTTTGACTGGACCCGTTTTGA-30) primer pairs.”
MethodSelf-citationFarahmand, M., Khales, P., Salavatiha, Z., Sabaei, M., Hamidzade, M., Aminpanah, D., & Tavakoli, A. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106209 · Cited by 29
A Novel Astrovirus-Like RNA Virus Detected in Human Stool
Munnink, B. O., Cotten, M., Canuti, M., Deijs, M., Jebbink, M., van Hemert, F. V., Phan, M. V. T., Bakker, M., Farsani, S. M. J., Kellam, P., et al. (2016) · Virus Evolution · doi:10.1093/ve/vew005 · Cited by 29
A novel astrovirus from dromedaries in the Middle East.
Woo, P. C. Y., Lau, S., Teng, J. L. L., Tsang, A. K. L., Joseph, S., Xie, J., Jose, S., Fan, R. Y. Y., Wernery, U., & Yuen, K. Y. (2015) · Journal of General Virology · doi:10.1099/jgv.0.000233 · Cited by 29
Afrad, M. H., Karmakar, P. C., Das, S., Matthijnssens, J., Ahmed, F., Nahar, S., Faruque, A. G., Rahman, M. Z., Rahman, M., & Azim, T. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2013.09.028 · Cited by 28
Call to Action for Dengue Vaccine Failure
Mahalingam, S., Herring, B., & Halstead, S. (2013) · Emerging Infectious Diseases · doi:10.3201/eid1908.121864 · Cited by 28
Environmental assessment reveals the presence of MLB‐1 human astrovirus in Uruguay
Lizasoain, A., Tort, L., García, M., Gómez, M. M., Leite, J. P. G., Miagostovich, M., Cristina, J., Colina, R., & Victoria, M. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12856 · Cited by 27
“Since 2009, several studies (Finkbeiner et al. 2009a,c; Kapoor et al. 2009) suggested the worldwide distribution of MLB-1 HAstV having been detected in different continents (Ahmed et al.”
BackgroundFirth, A., & Atkins, J. (2010) · Virology Journal · doi:10.1186/1743-422x-7-17 · Cited by 27
“[11] [12] [13] [14] for recent phylogenetic trees).”
Alternative cell lines to improve the rescue of infectious human astrovirus from a cDNA clone.
Velázquez-Moctezuma, R., Baños-Lara, M. D. R., Acevedo, Y., & Méndez, E. (2012) · Journal of Virological Methods · doi:10.1016/j.jviromet.2011.11.005 · Cited by 26
Moschidou, P., Martella, V., Lorusso, E., Desario, C., Pinto, P., Losurdo, M., Catella, C., Parisi, A., Bányai, K., & Buonavoglia, C. (2011) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638711404149 · Cited by 26
Unveiling Viruses Associated with Gastroenteritis Using a Metagenomics Approach
Fernandez-Cassi, X., Martínez-Puchol, S., Silva-Sales, M., Cornejo, T., Bartolomé, R., Bofill-Mas, S., & Girones, R. (2020) · Viruses · doi:10.3390/v12121432 · Cited by 25
“Recently, astroviruses have also been associated with a wider array of diseases, including central nervous system alterations such as meningitis or acute flaccid paralysis [57,58].”
BackgroundHigh prevalence of four novel astrovirus genotype species identified from rodents in China.
To, K., Chan, W., Li, K. S., Lam, C. S. F., Chen, Z.-W., Tse, H., Lau, S., Woo, P., & Yuen, K. Y. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000766 · Cited by 23
Molecular epidemiology of astrovirus in children with gastroenteritis in southwestern Nigeria
Arowolo, K. O., Ayolabi, C. I., Adeleye, I., Lapinski, B., Santos, J. S., & Raboni, S. M. (2020) · Archives of Virology · doi:10.1007/s00705-020-04741-0 · Cited by 22
The Viruses of the Gut Microbiota
Lecuit, M., & Éloit, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00021-5 · Cited by 26
“Parechovirus [36] Cardiovirus [37] Salivirus [38] Picobirnaviridae Picobirnavirus [16] Astroviridae Astrovirus [39] Reoviridae Rotavirus Caliciviridae Norovirus [40] Sapovirus [41] Adenoviridae Mastadenovirus C and F, and others [42] Anelloviridae Anellovirus [16] Cycloviridae Circovirus [43] Cyclovirus [43] Parvoviri…”
Structure of the divergent human astrovirus MLB capsid spike
Delgado-Cunningham, K., López, T., Khatib, F., Arias, C. F., & DuBois, R. M. (2022) · Structure · doi:10.1016/j.str.2022.10.010 · Cited by 22
Linsuwanon, P., Poovorawan, Y., Li, L., Deng, X., Vongpunsawad, S., & Delwart, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135573 · Cited by 21
“It is associated with gastroenteritis predominantly effecting young children [56].”
BackgroundSelf-citationHuman Astrovirus Infection in a Patient with New-Onset Celiac Disease
Smits, S. L., van Leeuwen, M., van der Eijk, A. A., Fraaij, P. L. A., Escher, J. C., Simon, J. H., & Osterhaus, A. D. M. E. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01164-10 · Cited by 26
“as described above, and a degenerate astrovirus PCR (14) (Fig.”
BackgroundResultInfluentialMi, S., Guo, S., Xing, C., Xiao, C., He, B., Wu, B., Xia, X., Tu, C., & Gong, W. (2020) · Journal of Virology · doi:10.1128/jvi.01513-20 · Cited by 20
Complete Genome of a Novel Porcine Astrovirus
Shan, T., Wang, C., Tong, W., Zheng, H., Hua, X.-G., Yang, S., Guo, Y.-F., Zhang, W., & Tong, G. (2012) · Journal of Virology · doi:10.1128/jvi.02598-12 · Cited by 20
“Recently, a group of novel astroviruses which were highly diverse was identified in humans and swine (3, 4, 8, 11, 14, 18).”
Background
Metadata
- Authors
- Kapoor, A., Li, L., Victoria, J., Oderinde, B., Mason, C., Pandey, P., Zaidi, S. Z., & Delwart, E.
- Affiliations
- University of California, San Francisco (US)
- University of Maiduguri (NG)
- Armed Forces Research Institute of Medical Science (TH)
- CIWEC Clinic Travel Medicine Center, Kathmandu, Nepal
- National Institute of Health (PK)
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2009-12-01
- Volume
- 90
- Issue
- 12
- Pages
- 2965-2972
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- PMC
- PMC2796194
- OpenAlex
- W2114025285
- Cited by
- 241
- References
- 33
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 13 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 17 · 2017: 17 · 2016: 17 · 2015: 17 · 2014: 14 · 2013: 22 · 2012: 23
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of General Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Blood Systems Research Institute
- National Heart, Lung, and Blood Institute (R01HL083254)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- human astrovirus, zoonotic transmission, viral emergence, viral genome, phylogenetic analysis, gastroenteritis
- MeSH terms
- Animals, Mamastrovirus, Diarrhea, Feces, Gastroenteritis, Humans, Molecular Sequence Data, Phylogeny, Species Specificity, Sequence Analysis, DNA, Astroviridae Infections
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