Feline foamy virus Tas protein is a DNA-binding transactivator
Abstract
Foamy viruses (FVs) harbour a transcriptional transactivator (Tas) and two Tas-responsive promoter regions, one in the 5′ long terminal repeat (LTR) and the other an internal promoter (IP) in the envelope gene. To analyse the mechanism of transactivation of the FVs, the specificity of feline FV (FFV) Tas protein, which is more distantly related to the respective proteins of non-human primate origin, were investigated. FFV Tas has been shown specifically to activate gene expression from the cognate promoters. No cross-transactivation was noted of the prototype foamy virus and human immunodeficiency virus type 1 LTR. The putative transactivation response element of FFV Tas was mapped to the 5′ LTR U3 region (approximately nt −228 to −195). FFV Tas binds to this element in addition to a previously described sequence (position −66 to −51). It is therefore concluded that FFV Tas is a DNA-binding transactivator that interacts with at least two regions in the virus LTR.
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Foamy viruses contain the classical LTR promoter that expresses the structural genes Gag/Pro/Pol and additionally have an internal promoter (IP) located toward the 3′ end of the env gene that can express only the two early regulatory genes tas and bet.
“They contain the classical LTR promoter that expresses the structural genes Gag/Pro/Pol, but additionally also have an internal promoter (IP) located toward the 3′ end of the env gene that can express only the two early regulatory genes, tas and bet.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Omoto et al. 2004
The basal activity of both foamy virus promoters can be trans-activated by the Tas protein.
“The basal activity of both promoters can be trans-activated by the Tas (trans-activator of spumavirus) protein (Baunach et al. 1993, Winkler et al. 1997, Omoto et al. 2004).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Omoto et al. 2004
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“The basal activity of both promoters can be trans -activated by the Tas ( trans -activator of spumavirus ) protein (Baunach et al. 1993 , Winkler et al. 1997 , Omoto et al. 2004 ).”
Foamy-like Endogenous Retroviruses Are Abundant and Extensive In Teleosts
Ruboyianes, R. S. (2015) · UA Campus Repository (The University of Arizona)
- Authors
- Omoto, S., Brisibe, E. A., Okuyama, H., & Fujii, Y. R.
- Affiliations
- Nagoya City University (JP)
- Research and Scientific Developments Division, Molecular Bio/Sciences Ltd, 124 MCC Road, Calabar, Cross River State, Nigeria
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2004-10-01
- Volume
- 85
- Issue
- 10
- Pages
- 2931-2935
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2092535838
- Cited by
- 9
- References
- 24
- Citations by year
- 2025: 1 · 2022: 1 · 2016: 2 · 2015: 1 · 2013: 2
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of General Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- feline foamy virus, long terminal repeat, internal promoter, HIV-1 LTR, env gene
- MeSH terms
- Animals, Base Sequence, Cats, DNA-Binding Proteins, Humans, Molecular Sequence Data, Promoter Regions, Genetic, Retroviridae Proteins, Trans-Activators, Spumavirus, HIV Long Terminal Repeat, Terminal Repeat Sequences
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