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Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibilities
Open accessPreprint — published as 10.1126/science.ade0705 · Paper page
Abstract
Horizontal gene transfer—the movement of genetic material between different species—has been reported across all major eukaryotic lineages, including vertebrates. However, the underlying mechanisms of transfer and their impact on genome evolution are still poorly understood. While studying the evolutionary origin of a selfish element in the nematode C. briggsae , we discovered that Mavericks , ancient viral-like transposons related to giant viruses and virophages, are one of the long-sought vectors of horizontal gene transfer. We found that Mavericks gained a novel herpesvirus-like fusogen in nematodes, leading to the widespread exchange of cargo genes between extremely divergent species, bypassing sexual and genetic barriers spanning hundreds of millions of years. Our results show how the union between viruses and transposons—nature’s melting pot—causes horizontal gene transfer and ultimately genetic incompatibilities in natural populations.
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Metadata
- Authors
- Widen, S. A., Bes, I. C., Koreshova, A., Krogull, D., & Burga, A.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Corresponding author
- Widen, Sonya A.
- Bes, Israel Campo
- Burga, Alejandro
- Venue
- Science
- Publisher
- openRxiv
- Published
- 2022-07-13
- Volume
- 380
- Issue
- 6652
- Pages
- eade0705-eade0705
- ISSN
- 0036-8075 (ISSN-L)
- OpenAlex
- W4382520369
- Cited by
- 78
- References
- 1
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 25 · 2023: 7
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- European Commission (2014‐2020, HORIZON2020)
- Österreichischen Akademie der Wissenschaften
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- horizontal gene transfer, genetic incompatibility, Caenorhabditis briggsae, nematodes, giant viruses, virophages, selfish genetic elements, genome evolution
- MeSH terms
- Animals, Caenorhabditis, DNA Transposable Elements, Biological Evolution, Genetic Vectors, Viruses, Gene Transfer, Horizontal
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