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PreprintCited by 51Obsessive-Compulsive Spectrum DisordersNeural dynamics and brain functionDeep Brain Stimulation and Movement Disorders

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Obsessive-Compulsive Disorder (OCD) is Associated with Increased Electroencephalographic (EEG) Delta and Theta Oscillatory Power but Reduced Delta Connectivity

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Perera, M. Prabhavi N., Mallawaarachchi, Sudaraka, Bailey, Neil W., Murphy, Oscar W., Fitzgerald, Paul B.·2022·Journal of Psychiatric Research
DOI 10.1101/2022.10.03.510571

Preprint — published as 10.1016/j.jpsychires.2023.05.026

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Abstract

Background: Obsessive-Compulsive Disorder (OCD) is a mental health condition causing significant decline in the quality of life of sufferers and the limited knowledge on the pathophysiology hinders successful treatment. The aim of the current study was to examine electroencephalographic (EEG) findings of OCD to broaden our understanding of the disease. Methods: Resting-state eyes-closed EEG data was recorded from 25 individuals with OCD and 27 healthy controls (HC). The 1/f arrhythmic activity was removed prior to computing oscillatory powers of all frequency bands (delta, theta, alpha, beta, gamma). Cluster-based permutation was used for between-group statistical analyses, and comparisons were performed for the 1/f slope and intercept parameters. Functional connectivity (FC) was measured using coherence and debiased weighted phase lag index (d-wPLI), and statistically analysed using the Network Based Statistic method. Results: Compared to HC, the OCD group showed increased oscillatory power in the delta and theta bands in the fronto-temporal and parietal brain regions. However, there were no significant between-group findings in other bands or 1/f parameters. The coherence measure showed significantly reduced FC in the delta band in OCD compared to HC but the d-wPLI analysis showed no significant differences. Conclusions: OCD is associated with raised oscillatory power in slow frequency bands in the fronto-temporal brain regions, which agrees with the previous literature and therefore is a potential biomarker. Although delta coherence was found to be lower in OCD, due to inconsistencies found between measures and the previous literature, further research is required to ascertain definitive conclusions.

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  • The previous study by Perera et al. (2022) using the same sample reported significantly elevated delta and theta power in the same centroparietal electrodes that showed higher negativity in the current study.

    “Moreover, our previous study of spectral power analysis in OCD using the same sample, reported significantly elevated delta and theta power in the same centroparietal electrodes showing higher negativity in the current study (Perera, Mallawaarachchi, Bailey, Murphy, & Fitzgerald, 2022).”

    From Obsessive–compulsive disorder (OCD) is associated with increased engagement of frontal brain regions across multiple event-related potentials (2023) · cites this paper as Perera, Mallawaarachchi, Bailey, Murphy, & Fitzgerald, 2022

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Metadata

Authors
Perera, M. P. N., Mallawaarachchi, S., Bailey, N. W., Murphy, O. W., & Fitzgerald, P. B.
Affiliations
  • Monash University (AU)
  • The University of Melbourne (AU)
  • Bionics Institute (AU)
  • Australian National University (AU)
Corresponding author
Perera, M. Prabhavi N.
ORCID
Venue
Journal of Psychiatric Research
Publisher
openRxiv
Published
2022-10-04
Volume
163
Pages
310-317
ISSN
0022-3956 (ISSN-L)
DOI
10.1101/2022.10.03.510571
OpenAlex
W4376256921
Cited by
51
References
1
Citations by year
2026: 17 · 2025: 18 · 2024: 14 · 2023: 2
FWCI
14.75
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Psychiatric Research (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • LivaNova
  • BrainsWay
  • Monash University
  • Medical Research Council
  • National Health and Medical Research Council (1193596, RES-20-0000-265A)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
obsessive-compulsive disorder, delta oscillations, theta oscillations, functional connectivity, delta coherence, 1/f scaling, biomarkers, resting-state EEG
MeSH terms
Brain, Brain Mapping, Electroencephalography, Humans, Magnetic Resonance Imaging, Obsessive-Compulsive Disorder, Quality of Life

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