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CUR(E)ating a New Approach to Study Fungal Effectors and Enhance Undergraduate Education through Authentic Research
Open accessPreprint — published as 10.1002/bmb.21783 · Paper page
Abstract
Course-based Undergraduate Research Experiences (CUREs) integrate active, discovery-based learning into undergraduate curriculums, adding tremendous value to Biochemistry and Molecular Biology (BMB) education. There are multiple challenges in transforming a research project into a CURE, such as the readiness of students, the time commitment of the instructor, and the productivity of the research. In this article, we report a CURE course developed and offered in the University of Massachusetts Amherst BMB Department since 2018 that addresses these challenges. Our CURE focuses on fungal effectors which are proteins secreted by a destructive pathogenic fungus Fusarium oxysporum , one of the top five most devastating plant pathogens. By studying this group of proteins, students are connected to real-world problems and participate in the search for potential solutions. A three-week “standard Bootcamp” is implemented to help students familiarize themselves with all basic techniques and boost their confidence. Next, molecular cloning, a versatile technique with modularity and repeatability, is used as the bedrock of the course. Our past five years of experience have confirmed that we have developed a novel and feasible CURE protocol. Measurable progress documented by students who took this course includes stimulated active learning and increased career trajectory to pursue hypothesis-based research to address societal needs. In addition, data generated through the course advance ongoing lab research. Collectively, we encourage the implementation of CURE among research-intensive faculty to provide a more inclusive research experience to all students, an important element in predicting career success.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Research works printed but not linked: 20
- 2013, Gayeski Preparing College Students for Real-World 2.0: Towards a Recipe for the ‘Secret Sauce’, Educational Technology, 53, 12
- 10.1187/cbe.10-03-0044 · DOI
- J. M. Heemstra , R. Waterman , J. M. Antos , P. J. Beuning , S. K. Bur , L. Columbus , et al. in R. Waterman , A. Feig (Eds.) (2017) ACS Symposium Series, American Chemical Society, Washington, DC, pp. 33–63. · DOI
- 2017, CUREs in biochemistry—where we are and where we should go, Biochem Mol Biol Educ, 45, 7, 10.1002/bmb.20989 · DOI
- 2021, Morris Agar Art: a CURE for the Microbiology Laboratory, J Microbiol Biol Educ, 22, e00121
- 2022, Worcester A Course-Based Undergraduate Research Experience (CURE) in Biology: Developing Systems Thinking through Field Experiences in Restoration Ecology, LSE, 21, ar20, 10.1187/cbe.20-12-0300 · DOI
- 2018, Undergraduate research, learning gain and equity: the impact of final year research projects, Higher Education Pedagogies, 3, 145, 10.1080/23752696.2018.1425097 · DOI
- 2018, Brownell Developing Course-Based Research Experiences in Discipline-Based Education Research: Lessons Learned and Recommendations, J Microbiol Biol Educ, 19, jmbe
- 2019, Holt Benefits and Challenges of Instructing Introductory Biology Course-Based Undergraduate Research Experiences (CUREs) as Perceived by Graduate Teaching Assistants, LSE, 18, ar43, 10.1187/cbe.18-09-0193 · DOI
- 10.1093/biosci/biv167 · DOI
- 10.1146/annurev-micro-092412-155650 · DOI
- A. Viljoen , L.-J. Ma , A. B. Molina in (2020) Emerging Plant Diseases and Global Food Security, The American Phytopathological Society,, pp. 159–184. · DOI
- 10.1002/bmb.20441 · DOI
- 2010, Provost Bringing the excitement and motivation of research to students; Using inquiry and research-based learning in a year-long biochemistry laboratoryLJ: Part II-research-based laboratory-a semester-long research approach using malate dehydrogenase as a research model, Biochem Mol Biol Educ, 38, 324, 10.1002/bmb.20401 · DOI
- A. C. Edmondson (2012) Teaming: How Organizations Learn, Innovate, and Compete in the Knowledge Economy. John Wiley & Sons,.
- 2021, Metatranscriptomic Comparison of Endophytic and Pathogenic Fusarium–Arabidopsis Interactions Reveals Plant Transcriptional Plasticity, MPMI, 34, 1071, 10.1094/MPMI-03-21-0063-R · DOI
- 10.1038/s41596-021-00628-9 · DOI
- 10.1126/science.abj8754 · DOI · Paper page
- 10.1093/NAR/GKAB1061 · DOI · Paper page
- 10.1002/sce.20173 · DOI · Paper page
Metadata
- Authors
- Li, G., McWilliams, M., Rodrigues, M., Mearkle, B., Jaafar, N., Golla, V., Yu, H., Yang, H., Ayhan, D. H., Allen, K., Martínez-Soto, D., Springer, A., & Ma, L.-J.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Ma, Li-Jun
- ORCID
- Venue
- Biochemistry and Molecular Biology Education
- Publisher
- openRxiv
- Published
- 2023-02-15
- Volume
- 52
- Issue
- 1
- Pages
- 6-14
- ISSN
- 1470-8175 (ISSN-L)
- PMC
- PMC10843451
- OpenAlex
- W4386704434
- Cited by
- 3
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Biochemistry and Molecular Biology Education (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- PubMed Central (submittedVersion)
- Funders
- National Science Foundation (IOS-165241, 2119918, CAREER)
- U.S. Department of Agriculture (MAS00496, 2016‐68004‐24931)
- National Institutes of Health
- National Institute of Food and Agriculture (2016-68004-24931, MAS00496)
- University of Massachusetts Amherst
- National Eye Institute (R01EY030150)
- Topics
- Social Sciences › Education › Science Education and Pedagogy
- Social Sciences › Education › Innovative Teaching Methods
- Social Sciences › Education › Problem and Project Based Learning
- Keywords
- course-based undergraduate research experiences, fungal effectors, Fusarium oxysporum, plant pathogenic fungi, gene cloning, undergraduate research training, active learning, student career outcomes, authentic research
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