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New components of the community based DNA-repair mechanism in Sulfolobales
Open accessPreprint — published as 10.1093/femsml/uqaf002 · Paper page
Abstract
After exposure to UV light, Sulfolobus acidocaldarius cells aggregate in a species-specific manner to exchange DNA and repair double-strand breaks via homologous recombination. The formation of cell-cell interactions is mediated by Ups pili. DNA exchange subsequently occurs through the Ced system, which imports DNA. To identify novel players in these processes, we investigated several genes upregulated after UV exposure by creating in-frame deletion mutants and performing cell aggregation and DNA exchange assays. This led to the identification of two novel components involved in the Ups and Ced systems: UpsC, a minor pilin of the Ups pili, and CedD, a VirD4-like ATPase essential for DNA import. Altogether, these findings provide new insights into the fascinating DNA damage response of Sulfolobales.
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Metadata
- Authors
- Recalde, A., Wagner, A., Sivabalasarma, S., Yurmashava, A., Fehr, N. P., Thurm, R., Le, T. N., Köbler, C., Wassmer, B., Albers, S.-V., & van Wolferen, M.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Albers, Sonja-Verena
- van Wolferen, Marleen
- ORCID
- Venue
- microLife
- Publisher
- openRxiv
- Published
- 2024-09-30
- Volume
- 6
- Pages
- uqaf002-uqaf002
- ISSN
- 2633-6693 (ISSN-L)
- PMC
- PMC11823120
- OpenAlex
- W4406605637
- Cited by
- 3
- References
- 1
- Citations by year
- 2026: 2 · 2025: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- microLife (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- California Department of Fish and Game (AL1206, 426849454)
- Deutsche Forschungsgemeinschaft (SFB1381, 426849454, AL1206)
- Albert-Ludwigs-Universität Freiburg
- Bộ Giáo dục và Ðào tạo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- Sulfolobales, DNA repair, homologous recombination, DNA double-strand break repair, cell aggregation, UV-induced DNA damage, DNA damage response, archaea
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