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Kinetic Model of Translational Autoregulation
Open accessPreprint — published as 10.1021/acs.jpcb.8b09503 · Paper page
Abstract
We investigate dynamics of a kinetic model of inhibitory autoregulation as exemplified when a protein inhibits its own production by interfering with its messenger RNA, known in molecular biology as translational autoregulation. We first show how linear models without feedback set the stage with a nonequilibrium steady state that constitutes the target of the regulation. However, regulation in the simple linear model is far from optimal. The negative feedback mechanism whereby the protein “jams” the mRNA greatly enhances the effectiveness of the control, with response to perturbation that is targeted, rapid, and metabolically efficient. Understanding the full dynamics of the system phase space is essential to understanding the autoregulation process.
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Metadata
- Authors
- Tyng, V., & Kellman, M. E.
- Affiliations
- University of Oregon (US)
- Corresponding author
- Kellman, Michael E.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- openRxiv
- Published
- 2018-10-03
- Volume
- 123
- Issue
- 2
- Pages
- 369-378
- ISSN
- 1520-5207 (ISSN-L)
- OpenAlex
- W2950769926
- Cited by
- 5
- References
- 1
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 1
- FWCI
- 0.09
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- The Journal of Physical Chemistry B (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- University of Oregon Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Advanced Thermodynamics and Statistical Mechanics
- Keywords
- negative feedback, protein synthesis regulation, nonequilibrium steady states, linear kinetic model, phase space dynamics, metabolic efficiency
- MeSH terms
- Feedback, Homeostasis, Kinetics, Models, Genetic, Proteins, RNA, Messenger, Protein Biosynthesis
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- Tyng, V., & Kellman, M. E. (2018). Kinetic Model of Translational Autoregulation. The Journal of Physical Chemistry B. https://doi.org/10.1101/432658
