Neural signatures of loss of consciousness and its recovery by thalamic stimulation
Open accessAbstract
We know that general anesthesia produces unconsciousness but not quite how. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non-human primates (NHPs) with propofol. Unconsciousness was marked by slow frequency (∼1 Hz) oscillations in local field potentials, entraining local spiking to Up states alternating with Down states of little spiking, and decreased higher frequency (>4 Hz) coherence. The thalamus contributed to cortical rhythms. Its stimulation “awakened” anesthetized NHPs and reversed the electrophysiologic features of unconsciousness. Unconsciousness thus resulted from slow frequency hypersynchrony and loss of high-frequency dynamics, partly mediated by the thalamus, that disrupts cortical communication/integration.
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Electrical stimulation of the central thalamus reverses the anesthetized state in non-human primates and is associated with return of corticocortical connectivity.
“Indeed, electrical stimulation of the central thalamus has recently been shown to reverse the anesthetized state in non-human primates, in association with a return of corticocortical connectivity (Donoghue et al., 2019; Redinbaugh et al., 2020; J. Tasserie et al., 2019, Soc. Neurosci., conference).).”
From Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) · cites this paper as Donoghue et al., 2019
The Abstract (page not specified) reports that central-thalamus stimulation awakened propofol-anesthetized non-human primates and restored awake-like cortical activity. The paper discusses corticocortical coherence when comparing awake and unconscious states, but the passages on stimulation do not show that corticocortical connectivity returned during stimulation. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRecent animal studies demonstrate reversal of the anesthetized state with central thalamus stimulation, leading to return of functional corticocortical connectivity.
“This is consistent with recent animal studies demonstrating the reversal of the anesthetized state with stimulation of the central thalamus (Donoghue et al., 2019; Redinbaugh et al., 2020), leading to a return of functional corticocortical connectivity.”
From Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) · cites this paper as Donoghue et al., 2019
The paper reports that central-thalamus stimulation produced behavioral and cortical signs of wakefulness in propofol-anesthetized non-human primates (stimulation findings, Fig. 4). It also analyzes corticocortical coherence in awake versus unconscious states (Fig. 3), but our copy does not show that corticocortical connectivity returned during stimulation. (LLM, conf=0.85)
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Cites
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Arousal and Locomotion Make Distinct Contributions to Cortical Activity Patterns and Visual Encoding
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Self-citationGlobal Workspace Dynamics: Cortical “Binding and Propagation” Enables Conscious Contents
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Conscious Processing and the Global Neuronal Workspace Hypothesis
Mashour, G. A., Roelfsema, P., Changeux, J.-P., & Dehaene, S. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.026 · Cited by 1,164 · see citing works
“This is consistent with recent animal studies demonstrating the reversal of the anesthetized state with stimulation of the central thalamus (Donoghue et al., 2019; Redinbaugh et al., 2020), leading to a return of functional corticocortical connectivity.”
Result
- Authors
- Donoghue, J. A., Bastos, A. M., Yanar, J., Kornblith, S., Mahnke, M., Brown, E. N., & Miller, E. K.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Miller, Earl K.
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2019-10-17
- OpenAlex
- W2980434065
- Cited by
- 5
- References
- 4
- Citations by year
- 2024: 1 · 2023: 2 · 2020: 2
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Institute of Mental Health
- National Institute of General Medical Sciences (T32GM007753)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- loss of consciousness, general anesthesia, propofol, thalamic stimulation, thalamus, cortical oscillations, local field potentials, cortical synchronization, non-human primates, anesthesia recovery
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