The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Signaling to NF- B: Regulation by Ubiquitination
Open accessAbstract
The NF-kappaB pathway is a ubiquitous stress response that activates the NF-kappaB family of transcription factors. Antigen receptors, receptors of the innate immune system, and certain intracellular stressors are potent activators of this pathway. The transcriptional program that is activated is both antiapoptotic and highly proinflammatory. Indeed, any compromise in engagement of the pathway results in immunodeficiency, whereas constitutive activation generates a sustained inflammatory response that may promote malignancy. As such, NF-kappaB activation is under tight regulation by a number of post-translational modifications, including phosphorylation and ubiquitination. This article attempts to synthesize our current knowledge regarding the regulation of NF-kappaB signaling by ubiquitination, specifically highlighting the biochemical basis for both positive and negative feedback loops that function in unison to generate coordinated signals that are essential for the viability of metazoan animals.
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Cited by
Inflammation meets cancer, with NF-κB as the matchmaker
Ben-Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,373
The diverse and complex roles of NF-κB subunits in cancer
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NF‐κB signaling in inflammation and cancer
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Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
Bedford, L., Lowe, J., Dick, L. R., Mayer, R. J., & Brownell, J. E. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3321 · Cited by 563
NF-κB and the Transcriptional Control of Inflammation
(2018) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2017.07.007 · Cited by 498
Metadata
- Authors
- Wertz, I. E., & Dixit, V. M.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-07
- Volume
- 2
- Issue
- 3
- Pages
- a003350-a003350
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2168384602
- Cited by
- 300
- References
- 88
- Type
- posted content
- Language
- en
- Open access
- bronze
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