Signaling in Muscle Contraction
Open accessAbstract
Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth muscle. Although these are similar, there are striking differences in the pathways that can be attributed to the distinct functional roles of the different muscle types. Muscles contract in response to depolarization, activation of G-protein-coupled receptors and other stimuli. The actomyosin fibers responsible for contraction require an increase in the cytosolic levels of calcium, which signaling pathways induce by promoting influx from extracellular sources or release from intracellular stores. Rises in cytosolic calcium stimulate numerous downstream calcium-dependent signaling pathways, which can also regulate contraction. Alterations to the signaling pathways that initiate and sustain contraction and relaxation occur as a consequence of exercise and pathophysiological conditions.
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Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
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From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
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“These include muscle contraction [4], synaptic transmission [5], and embryonic development [6].”
- Authors
- Kuo, I. Y., & Ehrlich, B. E.
- Affiliations
- Yale University (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-02
- Volume
- 7
- Issue
- 2
- Pages
- a006023
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4315934
- OpenAlex
- W2005850081
- Cited by
- 424
- References
- 1
- Citations by year
- 2026: 31 · 2025: 70 · 2024: 57 · 2023: 59 · 2022: 43 · 2021: 61 · 2020: 40 · 2019: 33 · 2018: 14 · 2017: 9 · 2016: 5 · 2015: 1 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- muscle contraction, signaling pathways, striated muscle, skeletal muscle, myocardium, smooth muscle, calcium signaling, actomyosin, G protein-coupled receptors, depolarization, calcium influx, calcium release from intracellular stores, physical activity, muscle relaxation
- MeSH terms
- Cardiomegaly, Heart Failure, Malignant Hyperthermia, Models, Biological, Muscle Contraction, Muscle, Smooth, Muscle, Smooth, Vascular, Myocardium, Signal Transduction, Muscle, Skeletal, Calcium Signaling
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