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Cited by 27Vitamin D Research StudiesBone health and osteoporosis researchParathyroid Disorders and Treatments

Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk

Muscogiuri, Giovanna, Barrea, Luigi, Altieri, Barbara, Di Somma, Carolina, Bhattoa, Harjit pal, Laudisio, Daniela, Duval, Guillaume T., Pugliese, Gabriella +5 more·2019·Current Vascular Pharmacology
DOI 10.2174/1570161117666190408165805
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Abstract

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

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  • Low vitamin D status is associated with increased blood pressure, dyslipidemia, impaired insulin metabolism, sleep disturbances, thus increasing the risk of cardiovascular atherosclerosis.

    “Therefore, low vitamin D status has been associated with increased BP [139, 140], dyslipidemia [139, 140], impaired insulin metabolism [138], sleep disturbances [141, 142], thus increasing the risk of cardiovascular atherosclerosis [139, 140].”

    From Mediterranean Diet and Obesity-related Disorders: What is the Evidence? (2022) · cites this paper as [139]

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Authors
Muscogiuri, G., Barrea, L., Altieri, B., Di Somma, C., Bhattoa, H. P., Laudisio, D., Duval, G. T., Pugliese, G., Annweiler, C., Orio, F., Fakhouri, H., Savastano, S., & Colao, A.
Affiliations
  • Federico II University Hospital (IT)
  • IRCCS, SDN, Via Gianturco 113, 80143, Naples, Italy
  • University of Debrecen (HU)
  • Centre Hospitalier Universitaire d'Angers (FR)
  • Parthenope University of Naples (IT)
  • Department of Biochemistry and Molecular Biology, College of Medicine, Al Faisal University, Riyadh, Saudi Arabia
Corresponding author
Muscogiuri, Giovanna
ORCID
Venue
Current Vascular Pharmacology
Publisher
Bentham Science Publishers Ltd.
Published
2019-10-02
Volume
17
Issue
6
Pages
610-617
ISSN
1570-1611 (ISSN-L)
DOI
10.2174/1570161117666190408165805
OpenAlex
W2937584775
Cited by
27
References
100
Citations by year
2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 3
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • Current Vascular Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
  • CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords
calcium supplementation, vitamin D supplementation, cardiovascular risk, osteoporosis, bone mineral density, secondary hyperparathyroidism, vitamin D deficiency, bone health, muscle health, falls and fractures, 25-hydroxyvitamin D, cardiovascular side effects
MeSH terms
Animals, Calcium, Cardiovascular Diseases, Cardiovascular System, Humans, Hyperparathyroidism, Secondary, Osteoporosis, Risk Factors, Vitamin D, Vitamin D Deficiency, Biomarkers, Bone Remodeling, Treatment Outcome, Dietary Supplements, Osteoporotic Fractures

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