The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Thrombospondins
Open accessAbstract
Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo transient or longer-term interactions with other extracellular matrix components. They share properties with other matrix molecules, cytokines, adaptor proteins, and chaperones, modulate the organization of collagen fibrils, and bind and localize an array of growth factors or proteases. At cell surfaces, interactions with an array of receptors activate cell-dependent signaling and phenotypic outcomes. Through these dynamic, pleiotropic, and context-dependent pathways, mammalian thrombospondins contribute to wound healing and angiogenesis, vessel wall biology, connective tissue organization, and synaptogenesis. We overview the domain organization and structure of thrombospondins, key features of their evolution, and their cell biology. We discuss their roles in vivo, associations with human disease, and ongoing translational applications. In many respects, we are only beginning to appreciate the important roles of these proteins in physiology and pathology.
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Cites
Platelet α-granules: Basic biology and clinical correlates
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Self-citationExtracellular Matrix: Functions in the Nervous System
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Thrombospondin Plays a Vital Role in the Immune Privilege of the Eye
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“Nevertheless, biochemical and cellular analyses of the N700S and A387P SNPs of TSP-1 and TSP-4, respectively, have identified effects on calcium binding, protein conformation, and interactions with cells and ECM components of the vessel wall and platelet clot (Stenina et al. 2003, 2005; Narizhneva et al. 2004; Carlson…”
BackgroundEnhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells
Wang, Y., Wang, S., & Sheibani, N. (2006) · Microvascular Research · doi:10.1016/j.mvr.2006.02.004 · Cited by 34
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Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions
Hynes, R. O., & Naba, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004903 · Cited by 1,349
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
Halper, J., & Kjaer, M. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-007-7893-1_3 · Cited by 532
The extracellular matrix in breast cancer
Insua-Rodríguez, J., & Oskarsson, T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.017 · Cited by 470
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Metadata
- Authors
- Adams, J. C., & Lawler, J.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-08-29
- Volume
- 3
- Issue
- 10
- Pages
- a009712-a009712
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W4211045489
- Cited by
- 457
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- bronze
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