The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA Replication Timing
Open accessAbstract
Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin structure, and genome evolution. Recent advances in genome-scale mapping of replication kinetics have allowed these correlations to be explored in many species, cell types, and growth conditions, and these large data sets have allowed quantitative and computational analyses. One striking new correlation to emerge from these analyses is between replication timing and the three-dimensional structure of chromosomes. This correlation, which is significantly stronger than with any single histone modification or chromosome-binding protein, suggests that replication timing is controlled at the level of chromosomal domains. This conclusion dovetails with parallel work on the heterogeneity of origin firing and the competition between origins for limiting activators to suggest a model in which the stochastic probability of individual origin firing is modulated by chromosomal domain structure to produce patterns of replication. Whether these patterns have inherent biological functions or simply reflect higher-order genome structure is an open question.
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Replication timing and transcriptional control: beyond cause and effect--part II
Hiratani, I., Takebayashi, S.-I., Lu, J., & Gilbert, D. M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.02.002 · Cited by 140
Self-citation
Cited by
Integrative detection and analysis of structural variation in cancer genomes
Dixon, J. R., Xu, J., Dileep, V., Zhan, Y., Song, F., Le, V. T., Yardımcı, G. G., Chakraborty, A., Bann, D. V., Wang, Y., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0195-8 · Cited by 452
Self-citationBuisson, R., Boisvert, J. L., Benes, C. H., & Zou, L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.029 · Cited by 316
A global profile of replicative polymerase usage
Daigaku, Y., Keszthelyi, A., Müller, C. A., Miyabe, I., Brooks, T., Retkute, R., Hubank, M., Nieduszynski, C. A., & Carr, A. M. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2962 · Cited by 169
Gene functioning and storage within a folded genome
Razin, S. V., & Ulianov, S. V. (2017) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-017-0050-4 · Cited by 37
TopBP1 utilises a bipartite GINS binding mode to support genome replication
Day, M., Tetik, B., Parlak, M., Almeida-Hernández, Y., Räschle, M., Kaschani, F., Siegert, H., Marko, A., Sanchez-Garcia, E., Kaiser, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45946-0 · Cited by 14
Metadata
- Authors
- Rhind, N., & Gilbert, D. M.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-07-09
- Volume
- 5
- Issue
- 8
- Pages
- a010132-a010132
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2135922376
- Cited by
- 388
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Rhind, N., & Gilbert, D. M. (2013). DNA Replication Timing. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a010132
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