The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The JAK/STAT Pathway
Open accessAbstract
Cellular responses to dozens of cytokines and growth factors are mediated by the evolutionarily conserved Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway (Fig. 1).These responses include proliferation, differentiation, migration, apoptosis, and cell survival, depending on the signal, tissue, and cellular context.JAK/STATsignaling is essential for numerous developmental and homeostatic processes, including hematopoiesis, immune cell development, stem cell maintenance, organismal growth, and mammary gland development (Ghoreschi et al. 2009).Janus kinases (JAKs) were identified through sequence comparisons as a unique class of tyrosine kinases that contain both a catalytic domain and a second kinase-like IL-6 gp130
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Cites
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1×
“They were functionally linked to STATs and interferon signaling in powerful somatic cell genetic screens (Darnell et al. 1994; Schindler and Plumlee 2008).”
Janus kinases in immune cell signaling
Ghoreschi, K., Laurence, A., & O’Shea, J. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00754.x · Cited by 1,149
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Dawson, M. A., Bannister, A. J., Göttgens, B., Foster, S. D., Bartke, T., Green, A. R., & Kouzarides, T. (2009) · Nature · doi:10.1038/nature08448 · Cited by 622
JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions
Arbouzova, N. I., & Zeidler, M. P. (2006) · Development · doi:10.1242/dev.02411 · Cited by 397
Canonical and non-canonical JAK–STAT signaling
Li, W. X. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.008 · Cited by 290
Inteferons pen the JAK–STAT pathway
Schindler, C., & Plumlee, C. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.08.010 · Cited by 256
Therapeutic targeting of Janus kinases
Pesu, M., Laurence, A., Kishore, N., Zwillich, S. H., Chan, G., & O'Shea, J. J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00644.x · Cited by 231
Jatiani, S. S., Baker, S. J., Silverman, L. R., & Reddy, E. P. (2010) · Genes & Cancer · doi:10.1177/1947601910397187 · Cited by 228
Haan, C., Behrmann, I., & Haan, S. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01018.x · Cited by 64
Cited by
Sever, R., & Brugge, J. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006098 · Cited by 989
Mechanisms Linking Inflammation to Insulin Resistance
Chen, L., Chen, R., Wang, H., & Liang, F. (2015) · International Journal of Endocrinology · doi:10.1155/2015/508409 · Cited by 644
Inhibition of JAK-STAT signaling stimulates adult satellite cell function
Price, F. D., von Maltzahn, J., Bentzinger, C. F., Dumont, N. A., Yin, H., Chang, N. C., Wilson, D. H., Frenette, J., & Rudnicki, M. A. (2014) · Nature Medicine · doi:10.1038/nm.3655 · Cited by 433
Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning
Perrimon, N., Pitsouli, C., & Shilo, B.-Z. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005975 · Cited by 391
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341
Metadata
- Authors
- Harrison, D. A.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-03-01
- Volume
- 4
- Issue
- 3
- Pages
- a011205-a011205
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2172133051
- Cited by
- 417
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
