The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Canonical and non-canonical JAK–STAT signaling
Open accessAbstract
Aberrant activation of the JAK–STAT pathway has been implicated in many human cancers. It has widely been assumed that the effects of STAT activation are mediated by direct transcriptional induction of STAT target genes. However, recent findings in Drosophila have identified a non-canonical mode of JAK–STAT signaling, which directly controls heterochromatin stability. This indicates that the JAK–STAT pathway also controls cellular epigenetic status, which affects expression of genes beyond those under direct STAT transcriptional control. Given the evolutionary conservation of the canonical pathway among different species, the non-canonical mode of JAK–STAT signaling might also operate in vertebrates. In this review, canonical versus non-canonical JAK–STAT signaling and the implications for gene regulation and cancer formation are discussed.
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The JAK/STAT signaling pathway: from bench to clinic
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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Xue, C., Yao, Q., Gu, X., Shi, Q., Yuan, X., Chu, Q., Bao, Z., Lu, J., & Li, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01468-7 · Cited by 699
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Chen, L., Chen, R., Wang, H., & Liang, F. (2015) · International Journal of Endocrinology · doi:10.1155/2015/508409 · Cited by 644
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Carow, B., & Rottenberg, M. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00058 · Cited by 555
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Metadata
- Authors
- Li, W. X.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 18
- Issue
- 11
- Pages
- 545-551
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2011466676
- Cited by
- 290
- References
- 91
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
