The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response
Open accessAbstract
Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded proteins and exit as either folded proteins in transit to their target organelles or as misfolded proteins targeted for degradation. The unfolded protein response (UPR) maintains the protein-folding homeostasis within the ER, ensuring that the protein-folding capacity of the ER meets the load of client proteins. Activation of the UPR depends on three ER stress sensor proteins, Ire1, PERK, and ATF6. Although the consequences of activation are well understood, how these sensors detect ER stress remains unclear. Recent evidence suggests that yeast Ire1 directly binds to unfolded proteins, which induces its oligomerization and activation. BiP dissociation from Ire1 regulates this oligomeric equilibrium, ultimately modulating Ire1's sensitivity and duration of activation. The mechanistic principles of ER stress sensing are the focus of this review.
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Renault, T. T., Floros, K. V., Elkholi, R., Corrigan, K.-A., Kushnareva, Y., Wieder, S. Y., Lindtner, C., Serasinghe, M. N., Asciolla, J. J., Buettner, C., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.10.028 · Cited by 217
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Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021) · Nature Immunology · doi:10.1038/s41590-021-01065-2 · Cited by 141
The hyaluronidase, TMEM2, promotes ER homeostasis and longevity independent of the UPRER
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Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
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Metadata
- Authors
- Gardner, B. M., Pincus, D., Gotthardt, K., Gallagher, C. M., & Walter, P.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-06
- Volume
- 5
- Issue
- 3
- Pages
- a013169-a013169
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2153074213
- Cited by
- 721
- References
- 75
- Type
- posted content
- Language
- en
- Open access
- bronze
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