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The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER
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“Conversely, ectopic expression of human hyaluronidase TMEM2 promotes resistance to ER stress and extends lifespan in C. elegans through changes in p38/ERK MAPK signaling 254 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [254]
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Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3437 · Cited by 4,637
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BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369
Adamson, B., Norman, T. M., Jost, M., Cho, M. Y., Nuñez, J. K., Chen, Y., Villalta, J. E., Gilbert, L. A., Horlbeck, M. A., Hein, M. Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.048 · Cited by 1,193
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Eden, E., Lipson, D., Yogev, S., & Yakhini, Z. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030039 · Cited by 696
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Horlbeck, M. A., Xu, A., Wang, M., Bennett, N. K., Park, C. Y., Bogdanoff, D., Adamson, B., Chow, E. D., Kampmann, M., Peterson, T. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.010 · Cited by 319
The hallmarks of fibroblast ageing
Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.03.004 · Cited by 250
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease
Gerakis, Y., & Hetz, C. (2018) · The FEBS Journal · doi:10.1111/febs.14332 · Cited by 226
ECM in brain aging and dementia
Morawski, M., Filippov, M., Tzinia, A., Tsilibary, E., & Vargova, L. (2014) · Progress in Brain Research · doi:10.1016/b978-0-444-63486-3.00010-4 · Cited by 84 · cited 2×
“An increase in ER stress, changes to the ECM, as well an altered MAPK signaling have all been identified as characteristic cellular phenotypes in tissues undergoing age-associated decline (Brown and Naidoo, 2012; Kurz and Tan, 2004;Morawski et al., 2014; Robert and Labat-Robert, 2015; Tigges et al., 2014).”
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Mechanisms, regulation and functions of the unfolded protein response
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Metadata
- Authors
- Schinzel, R. T., Higuchi-Sanabria, R., Shalem, O., Moehle, E. A., Webster, B. M., Joe, L., Bar-Ziv, R., Frankino, P. A., Durieux, J., Pender, C., Kelet, N., Kumar, S. S., Savalia, N., Chi, H., Simic, M., Nguyen, N.-T., & Dillin, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 179
- Issue
- 6
- Pages
- 1306-1318.e18
- ISSN
- 0092-8674
- PMC
- PMC6913896
- Cited by
- 117
- References
- 10
- Language
- en
- Licence
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging
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