PreprintCited by 805Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisDiagnosis and treatment of tuberculosis

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis

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Seung, Kwonjune J., Keshavjee, Salmaan, Rich, Michael L.·2015·Cold Spring Harbor Perspectives in Medicine

Abstract

The continuing spread of drug-resistant tuberculosis (TB) is one of the most urgent and difficult challenges facing global TB control. Patients who are infected with strains resistant to isoniazid and rifampicin, called multidrug-resistant (MDR) TB, are practically incurable by standard first-line treatment. In 2012, there were approximately 450,000 new cases and 170,000 deaths because of MDR-TB. Extensively drug-resistant (XDR) TB refers to MDR-TB strains that are resistant to fluoroquinolones and second-line injectable drugs. The main causes of the spread of resistant TB are weak medical systems, amplification of resistance patterns through incorrect treatment, and transmission in communities and facilities. Although patients harboring MDR and XDR strains present a formidable challenge for treatment, cure is often possible with early identification of resistance and use of a properly designed regimen. Community-based programs can improve treatment outcomes by allowing patients to be treated in their homes and addressing socioeconomic barriers to adherence.

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  1. Garcia-Prats AJ, Donald PR, Hesseling AC, Schaaf HS. 2013. Second-Line antituberculosis drugs in children: A commis- sioned review for the World Health Organization 19th Ex- pert Committee on the Selection and Use of Essential Med- icines. World Health Organization, Geneva.

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Metadata

Authors
Seung, K. J., Keshavjee, S., & Rich, M. L.
Affiliations
Brigham and Women's Hospital (US)
Venue
Cold Spring Harbor Perspectives in Medicine
Published
2015-04-27
Volume
5
Issue
9
Pages
a017863
ISSN
2157-1422 (ISSN-L)
OpenAlex
W2107340859
Cited by
805
References
32
Citations by year
2026: 70 · 2025: 147 · 2024: 136 · 2023: 165 · 2022: 105 · 2021: 72 · 2020: 52 · 2019: 20 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 4
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Medicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
Keywords
multidrug-resistant tuberculosis, extensively drug-resistant tuberculosis, isoniazid resistance, rifampicin resistance, fluoroquinolone resistance, second-line injectable drugs, transmission of drug-resistant strains, medication adherence, community-based treatment, global tuberculosis control, resistance monitoring
MeSH terms
Antitubercular Agents, Child, Community Health Services, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Isoniazid, Pregnancy, Pregnancy Complications, Infectious, Rifampin, Global Health, Drug Design, HIV Infections, Tuberculosis, Multidrug-Resistant, Fluoroquinolones, Extensively Drug-Resistant Tuberculosis, Coinfection

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