The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Tetracycline Antibiotics and Resistance
Open accessAbstract
Tetracyclines possess many properties considered ideal for antibiotic drugs, including activity against Gram-positive and -negative pathogens, proven clinical safety, acceptable tolerability, and the availability of intravenous (IV) and oral formulations for most members of the class. As with all antibiotic classes, the antimicrobial activities of tetracyclines are subject to both class-specific and intrinsic antibiotic-resistance mechanisms. Since the discovery of the first tetracyclines more than 60 years ago, ongoing optimization of the core scaffold has produced tetracyclines in clinical use and development that are capable of thwarting many of these resistance mechanisms. New chemistry approaches have enabled the creation of synthetic derivatives with improved in vitro potency and in vivo efficacy, ensuring that the full potential of the class can be explored for use against current and emerging multidrug-resistant (MDR) pathogens, including carbapenem-resistant Enterobacteriaceae, MDR Acinetobacter species, and Pseudomonas aeruginosa.
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Citations
Cites
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
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“In the T. thermophilus crystal structure, these S10 residues map to a loop projecting toward the aminoacyl-tRNA-binding site in the 30S structure (Brodersen et al. 2000; Carter et al. 2000).”
BackgroundInfluentialRibosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
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Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
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“Pseudomonas aeruginosa strains are generally less susceptible to tetracycline antibiotics, including tigecycline, and this is largely because of expression of the MexAB-OprM, MexCDOprJ, MexXY-OprM pumps (Dean et al. 2003).”
BackgroundJenner, L., Starosta, A. L., Terry, D. S., Mikolajka, A., Filonava, L., Yusupov, M., Blanchard, S. C., Wilson, D. N., & Yusupova, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216691110 · Cited by 204
Visalli, M. A., Murphy, E., Projan, S. J., & Bradford, P. A. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.2.665-669.2003 · Cited by 165 · cited 2×
“…et al. 2000; Morita et al. 2001; Chuanchuen et al. 2002; Dean et al. 2003; Schweizer 2003 P. mirabilis RND AcrAB: tigecycline, minocycline Visalli et al. 2003 S. aureus MATE MepA: tigecycline, eravacycline (not tetracycline) NorB: tetracycline (not minocycline) McAleese et al. 2005;…”
BackgroundTarget- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic
Grossman, T. H., Starosta, A. L., Fyfe, C., O'Brien, W., Rothstein, D. M., Mikolajka, A., Wilson, D. N., & Sutcliffe, J. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06187-11 · Cited by 162
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Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
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Mechanism of Tet(O)‐mediated tetracycline resistance
Connell, S. R., Trieber, C. A., Dinos, G. P., Einfeldt, E., Taylor, D. E., & Nierhaus, K. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg093 · Cited by 127
Cited by
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
Challenges of Repurposing Tetracyclines for the Treatment of Alzheimer’s and Parkinson’s Disease
Markulin, I., Matasin, M., Turk, V. E., & Salković-Petrisic, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02457-2 · Cited by 36
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria
Rozman, V., Mohar Lorbeg, P., Treven, P., Accetto, T., Janežič, S., Rupnik, M., & Bogovič Matijašić, B. (2023) · Life Science Alliance · doi:10.26508/lsa.202201637 · Cited by 36
Chauhan, P., Kakkar, A. K., Singh, H., & Gautam, C. S. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1838276 · Cited by 12
Dual site targeting of the bacterial 70S ribosome by tetracyclines
Devarkar, S. C., Lomakin, I. B., Wang, J., Grada, A., & Bunick, C. G. (2026) · Nature Communications · doi:10.1038/s41467-026-72788-9 · Cited by 2
Metadata
- Authors
- Grossman, T. H.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-03-17
- Volume
- 6
- Issue
- 4
- Pages
- a025387
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2298318901
- Cited by
- 725
- References
- 13
- Type
- posted content
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
