AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis
Open accessAbstract
Tigecycline has good broad-spectrum activity against many gram-positive and gram-negative pathogens with the notable exception of the Proteeae . A study was performed to identify the mechanism responsible for the reduced susceptibility to tigecycline in Proteus mirabilis . Two independent transposon insertion mutants of P. mirabilis that had 16-fold-increased susceptibility to tigecycline were mapped to the acrB gene homolog of the Escherichia coli AcrRAB efflux system. Wild-type levels of decreased susceptibility to tigecycline were restored to the insertion mutants by complementation with a clone containing a PCR-derived fragment from the parental wild-type acrRAB efflux gene cluster. The AcrAB transport system appears to be associated with the intrinsic reduced susceptibility to tigecycline in P. mirabilis .
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MDR efflux pumps AcrAB-TolC in Enterobacteriaceae and MexAB-OprM in P. aeruginosa, both RND-family pumps, extrude tetracyclines including tigecycline as part of their contribution to multidrug resistance.
“In addition to the tetracycline-specific transport systems, several MDR efflux pumps like AcrAB-TolC in Enterobacteriaceae and MexAB-OprM in P. aeruginosa (both belonging to the RND family) are able to extrude tetracyclines (including tigecycline) as part of their contribution to multidrug resistance (48, 49).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [48]
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically
Ferraro, M. J. (2000) · Cited by 16,875 · see citing works
National Committee for Clinical Laboratory Standards
Bruck, E. (1980) · PEDIATRICS · doi:10.1542/peds.65.1.187 · Cited by 14,736 · see citing works
REPLICA PLATING AND INDIRECT SELECTION OF BACTERIAL MUTANTS
Lederberg, J., & Lederberg, E. M. (1952) · Journal of Bacteriology · doi:10.1128/jb.63.3.399-406.1952 · Cited by 1,371 · see citing works
Multidrug efflux pumps of gram-negative bacteria
Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.20.5853-5859.1996 · Cited by 1,095 · see citing works
Okusu, H., Ma, D., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.1.306-308.1996 · Cited by 818 · see citing works
Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P., & TESTA, R. T. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.4.738 · Cited by 413 · see citing works
Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
Fralick, J. A. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5803-5805.1996 · Cited by 409 · see citing works
Françoise Van Bambeke, A., Balzi, E., & Tulkens, P. M. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00291-4 · Cited by 404 · see citing works
McMurry, L. M., Oethinger, M. D., & Levy, S. B. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13905.x · Cited by 346 · see citing works
Efflux pumps and drug resistance in Gram-negative bacteria
Ma, D., Cook, D. N., Hearst, J. E., & Nikaido, H. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90654-8 · Cited by 282 · see citing works
Gales, A. C., & Jones, R. N. (2000) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(99)00092-9 · Cited by 189 · see citing works
Srikumar, R., Kon, T., Gotoh, N., & Poole, K. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.65 · Cited by 184 · see citing works
Sum, P., & Petersen, P. J. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(99)00216-4 · Cited by 173 · see citing works
Balancing the drug-resistance equation
Levy, S. B. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90607-6 · Cited by 148 · see citing works
The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump
Sánchez, L., Pan, W., Viñas, M., & Nikaido, H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.21.6855-6857.1997 · Cited by 143 · see citing works
Piddock, L. J. V., White, D. G., Gensberg, K., Pumbwe, L., & Griggs, D. J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3118-3121.2000 · Cited by 137 · see citing works
Mazzariol, A., Tokue, Y., Kanegawa, T. M., Cornaglia, G., & Nikaido, H. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.12.3441-3443.2000 · Cited by 124 · see citing works
Gene expression response to misfolded protein as a screen for soluble recombinant protein
Lesley, S. A., Graziano, J., Cho, C. Y., Knuth, M. W., & Klock, H. E. (2002) · Protein Engineering Design and Selection · doi:10.1093/protein/15.2.153 · Cited by 113 · see citing works
Epidemiology of tetracycline-resistance determinants
Roberts, M. C. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90610-6 · Cited by 110 · see citing works
In Vitro Activities of the Glycylcycline GAR-936 against Gram-Positive Bacteria
Boucher, H. W., Wennersten, C. B., & Eliopoulos, G. M. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.8.2225-2229.2000 · Cited by 98 · see citing works
Hoellman, D. B., Pankuch, G. A., Jacobs, M. R., & Appelbaum, P. C. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.4.1085-1088.2000 · Cited by 65 · see citing works
Resistance to Methotrexate Due to AcrAB-Dependent Export from Escherichia coli
Kopytek, S., Dyer, J. C. D., Knapp, G. S., & Hu, J. C. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3210-3212.2000 · Cited by 42 · see citing works
Extrachromosomal resistance in Gram-negative organisms: the evolution of β-lactamase
Jacoby, G. A. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90611-4 · Cited by 35 · see citing works
Linde, H. ‐., Notka, F., Irtenkauf, C., Decker, J., Wild, J., Niller, H. H., Heisig, P., & Lehn, N. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/49.4.625 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782 · see citing works
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
Li, X.-Z., Plésiat, P., & Nikaido, H. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00117-14 · Cited by 1,648 · see citing works
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,523 · see citing works
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231 · see citing works
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082 · see citing works
Beceiro, A., Tomás, M., & Bou, G. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00059-12 · Cited by 1,078 · see citing works
Efflux-Mediated Drug Resistance in Bacteria
Li, X.-Z., & Nikaido, H. (2009) · Drugs · doi:10.2165/11317030-000000000-00000 · Cited by 976 · see citing works
Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance
Fernández, L., & Hancock, R. E. W. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00043-12 · Cited by 905 · see citing works
Efflux-Mediated Drug Resistance in Bacteria
Li, X.-Z., & Nikaido, H. (2004) · Drugs · doi:10.2165/00003495-200464020-00004 · Cited by 803 · see citing works
Tetracycline Antibiotics and ResistancePreprint
Grossman, T. H. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025387 · Cited by 737 · see citing works
The role of antibiotics and antibiotic resistance in nature
Aminov, R. I. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01972.x · Cited by 689 · see citing works
Efflux-mediated multiresistance in Gram-negative bacteria
Poole, K. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2004.00763.x · Cited by 612 · see citing works
Bacterial resistance to antibiotics: Active efflux and reduced uptake
Kumar, A., & Schweizer, H. P. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.04.004 · Cited by 537 · see citing works
Mechanisms of antibiotic resistance
Munita, J. M., & Arias, C. A. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch17 · Cited by 421 · see citing works
Damier-Piolle, L., Magnet, S., Brémont, S., Lambert, T., & Courvalin, P. M. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00732-07 · Cited by 356 · see citing works
Hawkey, P. M., Warren, R. E., Livermore, D. M., McNulty, C. A. M., Enoch, D., Otter, J. A., & Wilson, A. P. R. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky027 · Cited by 331 · see citing works
Pankey, G. A. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki248 · Cited by 299 · see citing works
Tigecycline: A Critical Analysis
Stein, G. E., & Craig, W. A. (2006) · Clinical Infectious Diseases · doi:10.1086/505494 · Cited by 295 · see citing works
Bender, J. K., Cattoir, V., Hegstad, K., Sadowy, E., Coque, T. M., Westh, H., Hammerum, A. M., Schaffer, K., Burns, K., Murchan, S., et al. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.10.002 · Cited by 281 · see citing works
Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii
Peleg, A. Y., Adams, J. M., & Paterson, D. L. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01198-06 · Cited by 257 · see citing works
Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report
Peleg, A. Y., Potoski, B. A., Rea, R. S., Adams, J. M., Sethi, J., Capitano, B., Husain, S., Kwak, E. J., Bhat, S. V., & Paterson, D. L. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl441 · Cited by 248 · see citing works
Ruzin, A. V., Keeney, D. R., & Bradford, P. A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm058 · Cited by 238 · see citing works
Self-citationAlav, I., Kobylka, J., Kuth, M. S., Pos, K. M., Picard, M., Blair, J. M. A., & Bavro, V. N. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00055 · Cited by 234 · see citing works
McAleese, F., Petersen, P. J., Ruzin, A. V., Dunman, P. M., Murphy, E., Projan, S. J., & Bradford, P. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1865-1871.2005 · Cited by 233 · see citing works
Self-citationTigecycline: A New Glycylcycline for Treatment of Serious Infections
Noskin, G. A. (2005) · Clinical Infectious Diseases · doi:10.1086/431672 · Cited by 224 · see citing works
The Development of Third-Generation Tetracycline Antibiotics and New Perspectives
Rusu, A., & Buta, L. E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122085 · Cited by 221 · see citing works
Functional, biophysical, and structural bases for antibacterial activity of tigecycline
Olson, M. W., Ruzin, A., Feyfant, E., Rush, T. S., O'Connell, J., & Bradford, P. A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01499-05 · Cited by 207 · see citing works
Self-citationHoban, D. J., Bouchillon, S. K., Johnson, B., Johnson, J. L., & Dowzicky, M. J. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2005.06.001 · Cited by 201 · see citing works
Ruzin, A. V., Visalli, M. A., Keeney, D. R., & Bradford, P. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1017-1022.2005 · Cited by 203 · see citing works
Self-citationTigecycline: First of a New Class of Antimicrobial Agents
Rose, W. E., & Rybak, M. J. (2006) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.26.8.1099 · Cited by 196 · see citing works
Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa
Dreier, J., & Ruggerone, P. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00660 · Cited by 190 · see citing works
Kelesidis, T., Karageorgopoulos, D. E., Kelesidis, I., & Falagas, M. E. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn311 · Cited by 184 · see citing works
Stein, G. E., & Babinchak, T. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.12.004 · Cited by 183 · see citing works
The emergence of clinical resistance to tigecycline
Sun, Y., Cai, Y., Liu, X., Bai, N., Liang, B., & Wang, R. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.09.005 · Cited by 182 · see citing works
Newer antibacterial drugs for a new century
Devasahayam, G., Scheld, W. M., & Hoffman, P. S. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903505092 · Cited by 155 · see citing works
Keeney, D. R., Ruzin, A. V., McAleese, F., Murphy, E., & Bradford, P. A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm397 · Cited by 155 · see citing works
Self-citationLivermore, D. M., Mushtaq, S., Warner, M., & Woodford, N. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00436-16 · Cited by 152 · see citing works
Tigecycline: A glycylcycline antimicrobial agent
Doan, T.-L., Fung, H. B., Mehta, D., & Riska, P. F. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.08.011 · Cited by 152 · see citing works
Biological counterstrike: antibiotic resistance mechanisms of Gram-positive cocci
Woodford, N. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01140.x · Cited by 138 · see citing works
Villa, L., Feudi, C., Fortini, D., García-Fernández, A., & Carattoli, A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01803-13 · Cited by 136 · see citing works
Bialek-Davenet, S., Lavigne, J., Guyot, K., Mayer, N., Tournebize, R., Brisse, S., Leflon‐Guibout, V., & Nicolas-Chanoine, M.-H. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku340 · Cited by 136 · see citing works
Sekyere, J. O., Govinden, U., Bester, L. A., & Essack, S. Y. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13169 · Cited by 134 · see citing works
Bradford, P. A., Weaver‐Sands, D. T., & Petersen, P. J. (2005) · Clinical Infectious Diseases · doi:10.1086/431673 · Cited by 133 · see citing works
Self-citationTaking inventory: antibacterial agents currently at or beyond Phase 1
Bush, K., Macielag, M. J., & Weidner‐Wells, M. A. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.08.013 · Cited by 126 · see citing works
Entenza, J. M., & Moreillon, P. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2008.11.006 · Cited by 122 · see citing works
Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936)
Hirata, T., Saito, A., Nishino, K., Tamura, N., & Yamaguchi, A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2179-2184.2004 · Cited by 122 · see citing works
Presence of Tetracycline Resistance Determinants and Susceptibility to Tigecycline and Minocycline
Fluit, A. C., Florijn, A., Verhoef, J., & Milatović, D. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.4.1636-1638.2005 · Cited by 118 · see citing works
Wieczorek, P., Sacha, P., Hauschild, T., Żórawski, M., Krawczyk, M., & Tryniszewska, E. A. (2008) · Folia Histochemica et Cytobiologica · doi:10.2478/v10042-008-0056-x · Cited by 120 · see citing works
Hentschke, M., Wolters, M., Sobottka, I., Rohde, H., & Aepfelbacher, M. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00085-10 · Cited by 117 · see citing works
Karatzas, K. A. G., Randall, L. P., Webber, M., Piddock, L. J. V., Humphrey, T. J., Woodward, M. J., & Coldham, N. G. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01931-07 · Cited by 114 · see citing works
Keeney, D. R., Ruzin, A. V., & Bradford, P. A. (2007) · Microbial Drug Resistance · doi:10.1089/mdr.2006.9990 · Cited by 111 · see citing works
Self-citationEfflux systems in bacterial pathogens: An opportunity for therapeutic intervention? An industry view
Lynch, A. S. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.021 · Cited by 102 · see citing works
Vasilev, K. A., Reshedko, G., Orăsan, R., Sánchez, M., Teras, J., Babinchak, T., Dukart, G., Cooper, A., Dartois, N., Gandjini, H., et al. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn249 · Cited by 102 · see citing works
Tigecycline: a novel glycylcycline antibiotic
Zhanel, G. G., Karlowsky, J. A., Rubinstein, E., & Hoban, D. J. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.1.9 · Cited by 96 · see citing works
AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in Morganella morganii
Ruzin, A. V., Keeney, D. R., & Bradford, P. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.791-793.2005 · Cited by 93 · see citing works
Self-citationMechanisms and fitness costs of tigecycline resistance in Escherichia coli
Linkevičius, M., Sandegren, L., & Andersson, D. I. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt263 · Cited by 91 · see citing works
Pournaras, S., Koumaki, V., Spanakis, N., Gennimata, V., & Tsakris, A. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.04.017 · Cited by 91 · see citing works
Duffey, M., Jumde, R. P., da Costa, R. M. A., Ropponen, H., Blasco, B., & Piddock, L. J. V. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00091 · Cited by 88 · see citing works
Bouchillon, S. K., Hoban, D. J., Johnson, B., Johnson, J. L., Hsiung, A., & Dowzicky, M. J. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2005.06.004 · Cited by 87 · see citing works
Tigecycline: A new glycylcycline antimicrobial agent
Kasbekar, N. (2006) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp050487 · Cited by 86 · see citing works
Casey, A. L., Lambert, P. A., & Elliott, T. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(07)72175-1 · Cited by 85 · see citing works
Non-fermentative Gram-negative bacteria
Enoch, D., Birkett, C. I., & LUDLAM, H. A. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(07)72176-3 · Cited by 83 · see citing works
Bratu, S., Landman, D., George, A., Salvani, J., & Quale, J. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp186 · Cited by 81 · see citing works
Rubinstein, E., & Vaughan, D. (2005) · Drugs · doi:10.2165/00003495-200565100-00002 · Cited by 78 · see citing works
Bialek-Davenet, S., Marcon, E., Leflon‐Guibout, V., Lavigne, J., Bert, F., Moreau, R., & Nicolas-Chanoine, M.-H. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00156-11 · Cited by 73 · see citing works
Fritsche, T. R., Strabala, P., Sader, H. S., Dowzicky, M. J., & Jones, R. N. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2005.06.010 · Cited by 73 · see citing works
Clinical Pharmacokinetics and Pharmacodynamics of Tigecycline
Barbour, A., Schmidt, S., Ma, B., Schiefelbein, L., Rand, K. H., Burkhardt, O., & Derendorf, H. (2009) · Clinical Pharmacokinetics · doi:10.2165/11317100-000000000-00000 · Cited by 71 · see citing works
Frampton, J. E., & Curran, M. P. (2005) · Drugs · doi:10.2165/00003495-200565180-00008 · Cited by 66 · see citing works
Compound Efflux in Helicobacter pylori
Kutschke, A., & DeJonge, B. L. M. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.7.3009-3010.2005 · Cited by 64 · see citing works
Jones, C. H., Tuckman, M., Keeney, D. R., Ruzin, A. V., & Bradford, P. A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00883-08 · Cited by 61 · see citing works
Self-citationTigecycline: in-vitro performance as a predictor of clinical efficacy
Hawkey, P. M., & Finch, R. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01621.x · Cited by 60 · see citing works
Garrison, M. W., Neumiller, J. J., & Setter, S. M. (2005) · Clinical Therapeutics · doi:10.1016/j.clinthera.2005.01.007 · Cited by 60 · see citing works
Pérez, A., Canle, D., Latasa, C., Poza, M., Beceiro, A., Tomás, M., Fernández, A., Mallo, S., Pérez‐Castro, S., Molina, F., et al. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00072-07 · Cited by 58 · see citing works
Efflux pumps of Gram-negative bacteria in brief
Auda, I. G., Salman, I. M. A., & Odah, J. G. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100666 · Cited by 57 · see citing works
Microbiology of drugs for treating multiply drug-resistant Gram-positive bacteria
Eliopoulos, G. M. (2009) · Journal of Infection · doi:10.1016/s0163-4453(09)60004-9 · Cited by 49 · see citing works
Tigecycline: a new glycylcycline antimicrobial
Townsend, M. L., POUND, M. W., & Drew, R. H. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01188.x · Cited by 50 · see citing works
New advances in antibiotic development and discovery
Alekshun, M. N. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.2.117 · Cited by 50 · see citing works
Oritavancin and Tigecycline: Investigational Antimicrobials for Multidrug‐Resistant Bacteria
Guay, D. R. P. (2004) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.24.1.58.34808 · Cited by 47 · see citing works
Anaerobic choline metabolism in microcompartments promotes growth and swarming of P roteus mirabilis
Jameson, E., Fu, T., Brown, I. R., Paszkiewicz, K. H., Purdy, K. J., Frank, S., & Chen, Y. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13059 · Cited by 46 · see citing works
Lupien, A., Gingras, H., Leprohon, P., & Ouellette, M. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv211 · Cited by 46 · see citing works
Ruzin, A. V., Immermann, F. W., & Bradford, P. A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00591-08 · Cited by 46 · see citing works
Self-citationHentschke, M., Christner, M., Sobottka, I., Aepfelbacher, M., & Rohde, H. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00993-09 · Cited by 45 · see citing works
Kronvall, G., Karlsson, I., Walder, M., Sörberg, M., & Nilsson, L. E. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki489 · Cited by 43 · see citing works
Ruzin, A. V., Immermann, F. W., & Bradford, P. A. (2010) · Microbial Drug Resistance · doi:10.1089/mdr.2009.0131 · Cited by 41 · see citing works
Self-citationTian, Z., Liu, R., Zhang, H., Yang, M., & Zhang, Y. (2019) · Environment International · doi:10.1016/j.envint.2019.105008 · Cited by 40 · see citing works
Pakzad, I., Karin, M. Z., Taherikalani, M., Boustanshenas, M., & Lari, A. R. (2013) · Europe PMC (PubMed Central) · doi:10.3205/dgkh000215 · Cited by 37 · see citing works
Tigecycline challenge triggers sRNA production in Salmonella enterica serovar Typhimurium
Yu, J., & Schneiders, T. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-195 · Cited by 37 · see citing works
Tripartite efflux pumps of the RND superfamily: what did we learn from computational studies?
Athar, M., Gervasoni, S. I., Catte, A., Basciu, A., Malloci, G., Ruggerone, P., & Vargiu, A. V. (2023) · Microbiology · doi:10.1099/mic.0.001307 · Cited by 36 · see citing works
Current and novel antibiotics against resistant Gram-positive bacteria
Pérez, F. (2008) · Infection and Drug Resistance · doi:10.2147/idr.s3545 · Cited by 35 · see citing works
Tetracyclines, Glycylcyclines, and Chloramphenicol
Moffa, M. A., & Brook, I. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00026-6 · Cited by 39 · see citing works
Singh, A. K., Haldar, R., Mandal, D., & Kundu, M. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00460-06 · Cited by 36 · see citing works
Vouillamoz, J., Moreillon, P., Giddey, M., & Entenza, J. M. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm459 · Cited by 36 · see citing works
Gootz, T. D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.11.006 · Cited by 35 · see citing works
Miryala, S. K., Anbarasu, A., & Ramaiah, S. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29874 · Cited by 34 · see citing works
Darabi, A., Hocquet, D., & Dowzicky, M. J. (2010) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2009.12.009 · Cited by 34 · see citing works
Kalily, E., Hollander, A., Korin, B., Cymerman, I., & Yaron, S. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.03398-16 · Cited by 32 · see citing works
In vitro activity of tigecycline against strains isolated from diabetic foot ulcers
Sotto, A., Bouziges, N., Jourdan, N., Richard, J.-L., & Lavigne, J.-P. (2007) · Pathologie Biologie · doi:10.1016/j.patbio.2007.07.003 · Cited by 31 · see citing works
Study Group, Kresken, M., Becker, K., Seifert, H., Leitner, E., Körber-Irrgang, B., von Eiff, C., & Löschmann, P. A. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1197-y · Cited by 30 · see citing works
Cheng, N.-C., Hsueh, P., Liu, Y.-C., Shyr, J.-M., Huang, W.-K., Teng, L., & Liu, C. (2005) · Microbial Drug Resistance · doi:10.1089/mdr.2005.11.330 · Cited by 30 · see citing works
Evaluation of tigecycline activity in clinical isolates among Indian medical centers
Manoharan, A., Chatterjee, S., Madhan, S., & Mathai, D. C. (2010) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.72061 · Cited by 26 · see citing works
- Authors
- Visalli, M. A., Murphy, E., Projan, S. J., & Bradford, P. A.
- Affiliations
- Wyeth (US)
- Corresponding author
- Visalli, Melissa A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2003-02
- Volume
- 47
- Issue
- 2
- Pages
- 665-669
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC151746
- OpenAlex
- W1976898407
- Cited by
- 165
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- tigecycline, Proteus mirabilis, AcrAB efflux pump, multidrug efflux, transposon mutants, complementation, tetracycline resistance
- MeSH terms
- Tigecycline, Carrier Proteins, DNA Transposable Elements, Membrane Proteins, Minocycline, Proteus mirabilis, Drug Resistance, Bacterial, ATP-Binding Cassette, Sub-Family C Proteins, Escherichia coli Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review