Cited by 422Cancer Cells and MetastasisCancer, Hypoxia, and MetabolismMathematical Biology Tumor Growth

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Tumor Microenvironment and Differential Responses to Therapy

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Hirata, Eishu, Sahai, Erik·2017·Cold Spring Harbor Perspectives in Medicine

DOI 10.1101/cshperspect.a026781PMC PMC5495051

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Abstract

Cancer evolution plays a key role in both the development of tumors and their response to therapy. Like all evolutionary processes, tumor evolution is shaped by the environment. In tumors, this consists of a complex mixture of nontransformed cell types and extracellular matrix. Chemotherapy or radiotherapy imposes further strong selective pressures on cancer cells during cancer treatment. Here, we review how different components of the tumor microenvironment can modulate the response to chemo- and radiotherapy. We further describe how therapeutic strategies directly alter the composition, or function, of the tumor microenvironment, thereby further altering the selective pressures to which cancer cells are exposed. Last, we explore the consequences of these interactions for therapy outcomes and how to exploit our increasing understanding of the tumor microenvironment for therapeutic benefit.

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Authors: Hirata, E., & Sahai, E.
Affiliations: Kanazawa Medical University (JP)
The Francis Crick Institute (GB)
ORCID: Hirata, Eishu
Sahai, Erik
Venue: Cold Spring Harbor Perspectives in Medicine
Publisher: Cold Spring Harbor Laboratory
Published: 2017-02-17
Volume: 7
Issue: 7
Pages: a026781
ISSN: 2157-1422 (ISSN-L)
DOI: 10.1101/cshperspect.a026781
PMC: PMC5495051
OpenAlex: W2588118089
Cited by: 422
References: 130
Citations by year: 2026: 30 · 2025: 38 · 2024: 49 · 2023: 52 · 2022: 58 · 2021: 84 · 2020: 64 · 2019: 31 · 2018: 10 · 2017: 5
Type: posted content
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cold Spring Harbor Perspectives in Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Francis Crick Institute (10144)
Japan Society for the Promotion of Science (17K07181)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
Keywords: tumor microenvironment, tumor evolution, chemotherapy response, radiotherapy response, extracellular matrix, selection pressure, treatment options, cancer therapy outcomes
MeSH terms: Drug Therapy, Extracellular Matrix, Humans, Neoplasms, Radiotherapy, Tumor Microenvironment

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Tumor Microenvironment and Differential Responses to Therapy

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