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Tumor Microenvironment and Differential Responses to Therapy
Open accessAbstract
Cancer evolution plays a key role in both the development of tumors and their response to therapy. Like all evolutionary processes, tumor evolution is shaped by the environment. In tumors, this consists of a complex mixture of nontransformed cell types and extracellular matrix. Chemotherapy or radiotherapy imposes further strong selective pressures on cancer cells during cancer treatment. Here, we review how different components of the tumor microenvironment can modulate the response to chemo- and radiotherapy. We further describe how therapeutic strategies directly alter the composition, or function, of the tumor microenvironment, thereby further altering the selective pressures to which cancer cells are exposed. Last, we explore the consequences of these interactions for therapy outcomes and how to exploit our increasing understanding of the tumor microenvironment for therapeutic benefit.
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“both conventional DNA damaging chemotherapy and radiotherapy can trigger changes in CAF biology, with fibrosis being a common late side effect of radiotherapy151.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [151]
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Self-citation
Metadata
- Authors
- Hirata, E., & Sahai, E.
- Affiliations
- Kanazawa Medical University (JP)
- The Francis Crick Institute (GB)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-02-17
- Volume
- 7
- Issue
- 7
- Pages
- a026781
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC5495051
- OpenAlex
- W2588118089
- Cited by
- 422
- References
- 130
- Citations by year
- 2026: 30 · 2025: 38 · 2024: 49 · 2023: 52 · 2022: 58 · 2021: 84 · 2020: 64 · 2019: 31 · 2018: 10 · 2017: 5
- Type
- posted content
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Francis Crick Institute (10144)
- Japan Society for the Promotion of Science (17K07181)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- tumor microenvironment, tumor evolution, chemotherapy response, radiotherapy response, extracellular matrix, selection pressure, treatment options, cancer therapy outcomes
- MeSH terms
- Drug Therapy, Extracellular Matrix, Humans, Neoplasms, Radiotherapy, Tumor Microenvironment
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