Using Mendelian Randomization to Improve the Design of Randomized Trials

Cited by (339)

Items 101–200 of 339

1. Current state of nutritional psychiatry: A scoping review of randomized controlled trials
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2. Causal Association between Erectile Dysfunction with Urate Levels and Gout: A Two-Sample Mendelian Randomization Study
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3. Impaired immune metabolism in COPD driven by dysfunction of CXCL16 + alveolar macrophages: multivariate causal evidence
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4. Integrating Mendelian randomization and multi-omics analysis unravels gut microbiota-driven metabolic mechanisms in sepsis and identifies diagnostic biomarkers through experimental validation
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5. Mendelian randomization studies on the causal relationship between insomnia and disease
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6. Effect of viral hepatitis on type 2 diabetes: A Mendelian randomization study
   Yunfeng Yu, Gang Hu, Ke-Ke Tong, Xin-Yu Yang, Jingyi Wu, Rong Yu · 2024 · World Journal of Diabetes
7. Causal relationship between sleep traits and erectile dysfunction: Evidence from Mendelian Randomization analysis
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8. The impact of cortical and subcortical volumes on major depression risk: A genetic study
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9. Role of air pollution exposure in the alteration of brain cortical structure: A Mendelian randomization study
   Chaojuan Huang, Zimei Cheng, Xu Wu, Zhiwei Li, Mingxu Li, Xingliang Feng, Yuyang Zhang, Qian Zhao · 2025 · Ecotoxicology and Environmental Safety
10. Ankylosing spondylitis status and risk of secondary systemic amyloidosis: A two-sample mendelian randomization study
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11. The causal association between type 2 diabetes and spinal stenosis: A Mendelian randomization analysis
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12. The causal relationship between the human gut microbiota and pyogenic arthritis: a Mendelian randomization study
    BoLiang Bai, Long-Fei Luo, Feng Yao, Qian Sun, Xing-Guang Chen, Wen Zheng, Lang Jiang, Xiao-Dong Wang, Guang-hao Su · 2024 · Frontiers in Cellular and Infection Microbiology
13. Genetic analyses identify brain functional networks associated with the risk of Parkinson’s disease and drug-induced parkinsonism
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14. Complex Role of Circulating Triglycerides in Breast Cancer Onset and Survival: Insights From Two‐Sample Mendelian Randomization Study
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15. CAUSAL ASSOCIATION BETWEEN MEDICATION USE AND SEPSIS: A TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY
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16. Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study
    Jiaming Su, Jiyuan Hu, Hongfang Liu, Yan Guo, Yang Shi, Yicheng Zheng, Zhaoxi Dong, Jiayou Liu, Zheyu Xu, Xinhui Yu et al. · 2025 · Diabetology & Metabolic Syndrome
17. Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases
    Maria K. Sobczyk, Jie Zheng, George Davey Smith, Tom R. Gaunt · 2022 · medRxiv
18. A NATUrally Randomized trial Evaluating a vaccine-like strategy to lower LDL by inhibiting PCSK9 on the lifetime risk of major cardiovascular events (NATURE-PCSK9)
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19. Genetically Predicted Apolipoprotein E Levels with the Risk of Panvascular Diseases: A Mendelian Randomization Study
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20. Validation of TYK2 and exploration of PRSS36 as drug targets for psoriasis using Mendelian randomization
    Xin Dong Guo, Mengjun Tao, Xincan Ji, MengQi Han, Yue Shen, Cheng Hong, Hao‐Yang Guo, Wei Shi, Hui Shu Yuan · 2024 · Scientific Reports
21. The causal role of lipids in dementia: A Mendelian randomization study
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22. Causal relationship between inflammatory bowel disease and cardiovascular disease: a two-sample Mendelian randomized study
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23. Association of Sleep, Inflammation and Female Infertility: A Cross‐Sectional Survey and Genetic Approach
    Xin Xin, Jiaxi Li, Jinfu Zhang, Haicui Wu · 2025 · Brain and Behavior
24. Exploring the Causal Relationships and Underlying Mechanisms of Genetically Linked Immune Cells with Hemorrhagic Stroke
    Qi Li, Yingjie Shen, Yu Zhao, Yaolou Wang, Yongze Shen, Chunmei Guo, Shang Gao, Hongge Yang, Aili Gao, Hongsheng Liang · 2025 · Current Neurovascular Research
25. Mendelian randomization, lipids, and coronary artery disease: trade-offs between study designs and assumptions
    Joy Shi, Sonja A. Swanson, Elizabeth W. Diemer, Hanna Gerlovin, Daniel C. Posner, Peter W.F. Wilson, J. Michael Gaziano, Kelly Cho, Miguel Ángel Hernán, On Behalf of the VA Million Veteran Program · 2025 · American Journal of Epidemiology
26. Bidirectional causality between liver dysfunction and migraine: A mediating Mendelian randomization study
    Yi Su, Hua He, Lihua Hang · 2025 · Medicine
27. Causal effects of ferroptosis-related traits on ovarian dysfunction: insights from integrating genome-wide Mendelian randomization, DNA methylation, gene expression, and proteome
    Qun Yong Zhou, Bangli Song, Huifang Li, Yibo He, Hualiang Zhang, Jing Guo, Minjuan Wu, Wenjun Chen · 2025 · Journal of Ovarian Research
28. Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits
    Bin Zeng, Shuling Xu, Dongqi Zhou, Rumeng Chen, Yining Ding, Zhu Wu, Zhi Jie Zheng, Menghua Liu, Binsheng He, Sen Li et al. · 2025 · Medicine
29. Investigating causal relations between brain morphology and genetic risk variants in Parkinson’s disease
    Gabrielle Dagasso, Vibujithan Vigneshwaran, Anthony J Winder, Raissa Souza, Erik Y. Ohara, Matthias Wilms, Nils D. Forkert · 2025 · NeuroImage Clinical
30. Associations between lipoproteins and risk of ischemic stroke: a systematic review and meta-analysis of Mendelian randomization studies
    Yanwei Guo, Zhijian Guo, Yinnan Zhu, Zongzhi Xie, Caixin Yang, Shouyuan SUN · 2026 · Frontiers in Neurology
31. Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies
    Miguel Garcia‐Argibay, Robyn E. Wootton, Henrik Larsson, Manuel Mattheisen, Renato Polimanti, Sandra M. Meier · 2026 · Molecular Psychiatry
32. CAUSAL ROLES OF SERUM URIC ACID LEVELS AND GOUT IN SEPSIS: A MENDELIAN RANDOMIZATION STUDY
    Yujun Qin, Xia Yang, Ning Zong · 2024 · Shock
33. RETRACTED: Identification of potential therapeutic targets for breast cancer using Mendelian randomization analysis and drug target prediction
    Zhulan Huang, Hongping Zheng, Haiyu Wang, Haojie Ning, Aiwen Che, Cuidan Cai · 2024 · Environmental Toxicology · Retracted
34. Identification and Functional Investigation of Hub Genes Associated with Follicular Lymphoma
    Yidong Zhu, Xiaoyi Jin, Jun Liu, Wenzhong Yang · 2024 · Biochemical Genetics
35. Identification of biomarkers in multiple myeloma: A comprehensive study combining microarray analysis and Mendelian randomization
    Yidong Zhu, Jun Liu, Bo Wang · 2024 · Journal of Cellular and Molecular Medicine
36. Causal associations between chronic heart failure and the cerebral cortex: results from Mendelian randomization study and integrated bioinformatics analysis
    Liqi Peng, Huzhi Cai, Yanping Tang, Fang Zhou, Yuemei Liu, Zelin Xu, Qing-Yang Chen, Xinyu Chen · 2024 · Frontiers in Cardiovascular Medicine
37. Trans-ancestry analysis in over 799,000 individuals yields new insights into the genetic etiology of colorectal cancer
    Changlong Yang, Zhenglin Chang, Youguo Dai, Jinzhao Mo, Qitai Zhang, Mingming Zhu, Likun Luan, Jinhu Zhang, Baoqing Sun, Junyi Jia · 2024 · PLoS ONE
38. PM2.5 is linked to Alzheimer’s syndrome and delirium: a mendelian randomization analysis
    Xiaojin Sun · 2024 · International Journal of Clinical and Experimental Pathology
39. Mediation effect of plasma metabolites on the relationship between immune cells and the risk of prostatitis: A study by bidirectional 2-sample and Bayesian-weighted Mendelian randomization
    Chao Ding, Quanhua Gong, Shui Wan · 2024 · Medicine
40. Causal association between hypothyroidism and obstructive sleep apnea: A bidirectional 2-sample Mendelian Randomization study
    Ning Lu, Bi Chen, Pingli Liu, Cuocuo Wang, Zhaojun Lu, Shengli Li · 2024 · Medicine
41. Type 1 Diabetes and Cataracts: Investigating Mediating Effects of Serum Metabolites Using Bidirectional Mendelian Randomization
    Yumeng Shi, Jingxi Qin, Yankai Li, Jin Yang, Yi Lü · 2024 · Metabolites
42. Casual effect of ulcerative colitis on chronic heart failure: results from a bidirectional Mendelian randomization study
    Yuzhou Chu, Jianhua Li, Li Gong, Sheng Shao, Hao Chen, Pengfei He, Juntao Yan · 2025 · BMC Gastroenterology
43. Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis
    Yinghao Ren, Xin Wang, Weiliang Wang, Zeyu Wang · 2025 · Scientific Reports
44. Mendelian randomization study of lipid species reveals causal relationship with syphilis
    Weifeng Shen, Hui Zhou, Wei Wang, Wei Li · 2025 · AMB Express
45. Assessing the impact of common pain medications on gut microbiota composition and metabolites: insights from a Mendelian randomization study
    Wei Feng, Diefei Liang, Junxiong Qiu, Yuan Fu, Zhaopei Zeng, Jiarui Zhang, Xinyi Zhang, Jianwei Lin, Junmeng Zheng, Liling Lin · 2025 · Journal of Medical Microbiology
46. Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis
    Selena Wei Zhang, Jingze Guo, Yanxian Chen, Jiahao Liu, Yu Shu Huang, Xianwen Shang, Mingguang He · 2025 · Investigative Ophthalmology & Visual Science
47. Effect of the plasma lipidome, immune cells, inflammatory proteins, gut microbiota, and plasma metabolites on Alzheimer’s Disease: A two-sample Mendelian randomized study and mediation analysis
    Zenghui Liu, Lu Kuang, Xiaohui Zhou, Jiaxing Zhao, Qijun Chen, Huayu Yin, Xuehui Liu, Dabin Liu, Shao-Guo Wu, L.-C. Wu · 2025 · Brain Research
48. Analysis of the Relationship between Rheumatoid Arthritis and Osteoporosis Based on Mendelian Randomization
    Feichao Song, Chen Rong-rong, Shichang Ji, Bingjie Liu, Zhang Jun-feng · 2023 · Current Rheumatology Reviews
49. RETRACTED: Mendelian randomization based on immune cells in diabetic nephropathy
    Ye Zhou, Hengyan Zhang, Heguo Yan, Changxing Huang, Yangwen Liu · 2024 · Frontiers in Endocrinology · Retracted
50. Effect of vitamin D on health and disease
    Katerina Trajanoska, Fernando Rivadeneira, John Brent Richards, Despoina Manousaki · 2023 · Elsevier eBooks
51. Genetic influence of meningioma on cisplatin resistance: a Mendelian randomization analysis
    Kefu Yu, Ziming Li, Weizhong Shi, Shuxian Yang, Zhigang Zhao, Yang Li · 2024 · International Journal of Clinical Pharmacy
52. Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study
    Ke-Ke Tong, Yunfeng Yu, Xin-Yu Yang, Jingyi Wu, Rong Yu, Chuan-Chuan Tan · 2024 · World Journal of Diabetes
53. Keratoconus and inflammatory bowel disease: mendelian randomization
    Yiheng Jin, Yuanfeng Wang, Xu Qiu, Jiao Liu, Shugen Qu · 2024 · Frontiers in Genetics
54. Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study
    Yaming Du, Rui Wang, Xinzi Xu, Junli Wang, Wei Shao, Guohua Chen · 2024 · Frontiers in Neurology
55. Unveiling therapeutic targets for spinal stenosis from genetic insights: a Mendelian randomization analysis
    Zhaopeng Fan, Bohong Chen, Le Ding, Hua Guo · 2024 · Scientific Reports
56. Association of dietary preferences with primary ovarian insufficiency (POI): a mendelian randomization-based analysis
    Zhengqi Qiu, Emma Yun Zhi Huang, Yufei Li, Jun Cheng Du, Juntao Kan · 2024 · BMC Women s Health
57. Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study
    Dima Chaar, Aliya Yakubova, Chen Jiang, Thomas J. Hoffmann, Alice Rogot Pressman, Denis Plotnikov, Hélène Choquet · 2025 · Cephalalgia Reports
58. Causal Associations of Brain Imaging-Derived Phenotypes and Intracranial Aneurysm: A Bidirectional Mendelian Randomization Study
    Xiao Wu, Xichen Wan, Yue Tang, Yuxia Li, Zhen-Nan Ye, Haoyang Peng, Jincan Zhang, Li Pan, Peng Liu · 2025 · World Neurosurgery
59. Identification of effect modifiers using a stratified Mendelian randomization algorithmic framework
    Alice Man, Leona Knüsel, Josef Graf, Ricky Lali, Ann Le, Matteo Di Scipio, Pedrum Mohammadi‐Shemirani, Michael Chong, Marie Pigeyre, Zoltán Kutalik et al. · 2025 · European Journal of Epidemiology
60. Endothelial selective adhesion molecule and interleukin-16 play an intermediary role in psoriasis complicated with acute myocardial infarction: A Mendelian randomization study
    Xuan Kang, Chao Wang, Guoqiang Zhong, Hai-Jun Zhang · 2025 · Medicine
61. Mendelian randomization study supports the causal effects of air pollutants on cognitive function
    Yunyun Guo, Fei Gao, Yuxi Liang · 2025 · Atmospheric Pollution Research
62. Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis
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63. Genetic Association Between Sleep Traits and Vertigo Risk: A Two-sample Bidirectional Mendelian Randomization Study
    Weimin Xu, Engang Tian, Jun Wang, Xixi Yu, Zhaoqi Guo, Jingyu Chen, Sulin Zhang · 2025 · Current Molecular Medicine
64. The immune-related plasma protein LAT2 as a protective modulator in diabetic retinopathy: a Mendelian randomization study
    Ming Yang, Weizhen Wu · 2025 · Frontiers in Endocrinology
65. Genetic Association Between Rheumatoid Arthritis and Preeclampsia: A Bidirectional Mendelian Randomization and Bioinformatics Study
    Lixian Li, Xiaotian Li, Juanjuan Huang · 2025 · Maternal-Fetal Medicine
66. Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization
    Suwei Wang, Yuanjing Yang, Zeyu Pang, Yidan Li, Ke Li, Yan Sun, Jurong Yang · 2025 · Renal Failure
67. A Two‐Sample Mendelian Randomization Research Examining the Causal Association Between Ischemic Stroke and Obstructive Sleep Apnea
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68. Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study
    Xiaoqing Zhou, Yujie Zhou, Jialing Chen, Chen Chen, Ruilin Chen, Suqun Zheng, Zhen Wang, Linshui Zhou · 2025 · Journal of Asthma
69. Causal effect of serum lipopolysaccharide activity levels and inflammatory proteins on Alzheimer's disease: A Mendelian randomization study combined with meta-analysis in a large-scale cohort
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70. MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses
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71. Cerebrospinal Fluid Metabolites Mediate the Impact of Gut Microbiota on Amyotrophic Lateral Sclerosis: Novel Insights From Mendelian Randomization
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72. Multi-Omics Association Analysis of Mitochondrial Genes in Hypertrophic Scars: Application of Mendelian Randomization
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73. Causal genetic link between gut microbiome, metabolites, and autism spectrum disorder in a European cohort
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74. Genetic evidence supports therapeutic modulation of progranulin levels in Alzheimer’s Disease
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75. Gut microbiota, lipid metabolism, and PCOS: A Mendelian randomization and mediation analysis
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76. Phenome-Wide Mendelian Randomization Identifying Circulating Proteins for Cardiovascular Traits in Populations of African Ancestry
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77. Genetically predicted mannose-binding lectin levels and risk of future venous thromboembolism—the HUNT Study
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78. Lp(a) Has Specific Effects on Coronary Artery Disease Independent of LDL-C
    Moa P. Lee, Sarah H. Koenigsberg, Mohammad Yaser Anwar, Laura M. Raffield, Zhaotong Lin, Anna F Ballou, John N. Booth, Thibaut Davy-Méndez, Helina Kassahun, Shia T. Kent et al. · 2026 · JACC Advances
79. Exploring the Associations and Mechanisms Between Antihypertensive Drugs and Urological Tumors: Insights from a Mendelian Randomization Study
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80. Drug targets for lipid modification and risk of type 2 diabetes: a cis-Mendelian randomization study
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81. Genetically determined very low lipoprotein(a) is not associated with type 2 diabetes and glycemic traits
    Moa P. Lee, Paulina Baca, Fernando Rivas, Alice Zhang, Jesús Alegre-Díaz, Jaime Berumen-Campos, Pablo Kuri-Morales, Kari E. North, Carlos J. Rodriguez, Til Stürmer et al. · 2026 · American Journal of Preventive Cardiology
82. Association between urinary sodium and circulating lipid levels: a Mendelian randomization study
    Yuan Chi, Peijia Jing, Zhongyu Jian, Xin Wei · 2023 · Frontiers in Endocrinology
83. Association between 23 drugs and inflammatory bowel disease: a two-sample Mendelian randomization study
    Lei He, Tuo Deng, Yurong Huang, Wangliu Yang, Jie Yang, Gengqing Song · 2024 · Frontiers in Medicine
84. Exploring the role of mitochondrial proteins SIRT5 and MRPL33 through Mendelian randomization in primary biliary cholangitis
    Jingqin Hu, Yuqiang Mi, Li Wang, Feng Jiang, Ping Li · 2024 · Clinics and Research in Hepatology and Gastroenterology
85. Causal association between diabetes mellitus and rheumatoid arthritis: A bidirectional Mendelian randomization study
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86. Appraising the effectiveness of immune cells on thyroid cancer: a Mendelian randomization study
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87. Gut microbiota as a residual risk factor causally influencing cardiac structure and function: Mendelian randomization analysis and biological annotation
    Yihua Li, Meidan Yao, Fei Xie, Yijun Qiu, Xinjun Zhao, Rong Li · 2024 · Frontiers in Microbiology
88. Causal relationship between IgA nephropathy and common neuropsychiatric disorders: A two-sample Mendelian randomization analysis
    Lin Xu, Gui-Bing Chen, Keyi Li, Yajuan Xu · 2024 · Journal of Affective Disorders
89. Relationship between Guillain–Barré syndrome and cardiovascular disease: a bidirectional Mendelian randomization study
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90. The causal association of smoking, alcohol intake, and coffee intake with the risk of bacterial pneumonia: A Mendelian randomization study
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91. Genetic evidence supports the causal effects of exposure to ambient air pollution on autoimmune eye diseases
    Jun Zhang, Hongxia Yang, Lu Li, Shuqiong Hu, Yongqing Liu, Suyan Li, Wu Li, Tao He · 2025 · International Journal of Environmental Health Research
92. Association Between Chronic Obstructive Pulmonary Disease and Rheumatoid Arthritis: Findings of the Observational and Mendelian Randomization Study
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93. Comments on “An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk”
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94. Genetic determinants of micronutrient levels and their causal impact on osteonecrosis of the femoral head: A 2-sample Mendelian randomization study
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95. A causal association between serum mitochondrial-related proteins and the risk of chronic kidney disease
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96. Causal Relationship Between Matrix Metalloproteinase and Cervical Lesions: A Two-Sample Mendelian Randomization Analysis
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97. The Role of Endometriosis in Intestinal Inflammation: A Combined Mendelian Randomization and Cellular Study
    Zhigang Li, Fang Wang, Ernv Kang, Xiaoguang Zhen, Jianli Liu, Wenhao Wang · 2025 · Journal of Cellular and Molecular Medicine
98. Gut microbiota mediates the relationship between smoking and fall risk: A 2-step Mendelian randomization study
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99. Cathepsin causal association with pulmonary embolism: a Mendelian randomization analysis
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100. A Two-step Bayesian Mendelian Randomization Study on Cholecystitis and Dermatitis
     Chenyu Zhao, Chang-Qian Cen, Ruihan Zhang, Wenjin He, Yiyang Jiao, Zhuoya Chen, Zhaoqi Wu, Ting Luan · 2024 · medRxiv