Holmes, Michael V.

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Davies, N. M., Holmes, M. V., & Davey Smith, G. (2018) · BMJ

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 4,404

Mendelian randomization

Sanderson, E., Glymour, M. M., Holmes, M. V., Kang, H., Morrison, J., Munafò, M. R., Palmer, T., Schooling, C. M., Wallace, C., Zhao, Q., et al. (2022) · Nature Reviews Methods Primers

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 2,229

Guidelines for performing Mendelian randomization investigations

Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Holmes, M. V., Minelli, C., Relton, C. L., et al. (2020) · Wellcome Open Research

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 1,273

The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., et al. (2021) · Nature

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 972

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

Richardson, T. G., Sanderson, E., Palmer, T. M., Ala-Korpela, M., Ference, B. A., Davey Smith, G., & Holmes, M. V. (2020) · PLOS Medicine

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 843

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

Zheng, J., Haberland, V., Baird, D., Walker, V., Haycock, P., Hurle, M., Gutteridge, A., Erola, P., Liu, Y., Luo, S., et al. (2019) · Nature Genetics

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 812

Mendelian randomization of blood lipids for coronary heart disease

Holmes, M. V., Asselbergs, F. W., Palmer, T. M., Drenos, F., Lanktree, M. B., Nelson, C. P., Dale, C. E., Padmanabhan, S., Finan, C., Swerdlow, D. I., et al. (2015) · European Heart Journal

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 748

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen, L., Gustafsson, S., Wang, Q., Hansen, D. H., Hedman, Å. K., Schork, A., Page, K., Zhernakova, D. V., Wu, Y., Peters, J., et al. (2020) · Nature Metabolism

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 705

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Swerdlow, D. I., Preiss, D., Kuchenbaecker, K. B., Holmes, M. V., Engmann, J. E. L., Shah, T., Sofat, R., Stender, S., Johnson, P. C. D., Scott, R. A., et al. (2015) · The Lancet

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 680

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

Holmes, M. V., Ala-Korpela, M., & Smith, G. D. (2017) · Nature Reviews Cardiology

Genetic Associations and EpidemiologyNutrition, Genetics, and Disease

Cited by 679

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Holmes, M. V., Dale, C. E., Zuccolo, L., Silverwood, R. J., Guo, Y., Ye, Z., Prieto-Merino, D., Dehghan, A., Trompet, S., Wong, A., et al. (2014) · BMJ

Alcohol Consumption and Health EffectsGenetic Associations and Epidemiology

Cited by 669

Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China

Millwood, I. Y., Walters, R. G., Mei, X. W., Guo, Y., Yang, L., Bian, Z., Bennett, D. A., Chen, Y., Dong, C., Hu, R., et al. (2019) · The Lancet

Alcohol Consumption and Health EffectsGenetic Associations and Epidemiology

Cited by 514

Lipids, lipoproteins, and metabolites and risk of myocardial infarction and stroke

Holmes, M. V., Millwood, I. Y., Kartsonaki, C., Hill, M. R., Bennett, D. A., Boxall, R., Guo, Y., Xu, X., Bian, Z., Hu, R., et al. (2018) · Journal of the American College of Cardiology

Lipoproteins and Cardiovascular HealthMetabolomics and Mass Spectrometry Studies

Cited by 508

CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events: A Systematic Review and Meta-analysis

Holmes, M. V., Perel, P., Shah, T., Hingorani, A. D., & Casas, J. P. (2011) · JAMA

Antiplatelet Therapy and Cardiovascular DiseasesPharmacogenetics and Drug Metabolism

Cited by 472

GWAS identifies 14 loci for device-measured physical activity and sleep duration

Doherty, A., Smith-Byrne, K., Ferreira, T., Holmes, M. V., Holmes, C., Pulit, S. L., & Lindgren, C. M. (2018) · Nature Communications

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 408

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.

Swerdlow, D. I., Kuchenbaecker, K. B., Shah, S., Sofat, R., Holmes, M. V., White, J., Mindell, J. S., Kivimaki, M., Brunner, E. J., Whittaker, J. C., et al. (2016) · International Journal of Epidemiology

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 387

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., et al. (2017) · The Lancet Diabetes & Endocrinology

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 380

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis

Dale, C. E., Fatemifar, G., Palmer, T. M., White, J., Prieto-Merino, D., Zabaneh, D., Engmann, J. E. L., Shah, T., Wong, A., Warren, H. R., et al. (2017) · Circulation

Genetic Associations and EpidemiologyCardiovascular Disease and Adiposity

Cited by 345

Using Mendelian Randomization to Improve the Design of Randomized Trials

Ference, B. A., Holmes, M. V., & Smith, G. D. (2021) · Cold Spring Harbor Perspectives in Medicine

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 338

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation

Richardson, T. G., Leyden, G. M., Wang, Q., Bell, J. A., Elsworth, B., Davey Smith, G., & Holmes, M. V. (2022) · PLOS Biology

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 304

Association of Lipid Fractions With Risks for Coronary Artery Disease and Diabetes

White, J., Swerdlow, D. I., Preiss, D., Fairhurst-Hunter, Z., Keating, B. J., Asselbergs, F. W., Sattar, N., Humphries, S. E., Hingorani, A. D., & Holmes, M. V. (2016) · JAMA Cardiology

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 293

Mendel’s laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues

Davey Smith, G., Holmes, M. V., Davies, N. M., & Ebrahim, S. (2020) · European Journal of Epidemiology

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 287

Adherence to healthy lifestyle and cardiovascular diseases in the Chinese population

Lv, J., Yu, C., Guo, Y., Bian, Z., Yang, L., Chen, Y., Tang, X., Zhang, W., Qian, Y., Huang, Y., et al. (2017) · Journal of the American College of Cardiology

Cardiovascular Health and Risk FactorsNutritional Studies and Diet

Cited by 266

Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study

Lyall, D. M., Celis-Morales, C., Ward, J., Iliodromiti, S., Anderson, J. J., Gill, J. M. R., Smith, D. J., Ntuk, U. E., Mackay, D. F., Holmes, M. V., et al. (2017) · JAMA Cardiology

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 235