The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene

Coleman, K G; Poole, S J; Weir, M P; Soeller, W C; Kornberg, T

doi:10.1101/gad.1.1.19

Cited by 153Developmental Biology and Gene RegulationGenomics and Chromatin DynamicsNeurobiology and Insect Physiology Research

The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene

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Coleman, K G, Poole, S J, Weir, M P, Soeller, W C, Kornberg, T·1987·Genes & Development

DOI 10.1101/gad.1.1.19

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Abstract

The invected and engrailed genes are juxtaposed in the Drosophila genome and are closely related in sequence and pattern of expression. The structure of the most abundant invected transcript was defined by obtaining the full-length cDNA sequence and by S1 nuclease sensitivity and primer extension studies; a partial sequence of the invected gene was determined; and the developmental profile of invected expression was characterized by Northern analysis and by in situ localization. The invected gene, like the engrailed gene, is expressed in the embryonic and larval cells of the posterior developmental compartments and in the embryonic hindgut, clypeolabrum, and nervous system. Like the engrailed gene, the invected gene can encode a protein of approximately 60 kD that contains a homeo box near its carboxyl terminus; indeed, a sequence of 117 amino acids in the carboxy-terminal region of both proteins is almost identical. The developmental role of the invected gene is not known.

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Microexons, defined as 3-27 nucleotide exons, have been largely missed by genome annotations and transcriptome profiling studies, especially those shorter than 15 nucleotides.
“In particular, microexons (Beachy et al., 1985; Coleman et al., 1987), defined here as 3-27 nucleotide (nt)-long exons, have been largely missed by genome annotations and transcriptome profiling studies (Volfovsky et al., 2003; Wu et al., 2013; Wu and Watanabe, 2005). This is especially true for microexons shorter than 15 nts.”
From A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains (2014) · cites this paper as Coleman et al., 1987

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Authors: Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C., & Kornberg, T.
Affiliations: University of California, San Francisco (US)
ORCID: Coleman, K G
Poole, S J
Weir, M P
Kornberg, T
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1987-03
Volume: 1
Issue: 1
Pages: 19-28
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1.1.19
OpenAlex: W2096881883
Cited by: 153
References: 23
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 1
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: engrailed, homeobox genes, Drosophila, gene sequence homology, gene expression patterns, hindgut, clypeolabrum, nervous system, cDNA sequence
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, DNA, Drosophila melanogaster, Gene Expression Regulation, Genes, Genes, Homeobox, Molecular Sequence Data, Proteins, Transcription, Genetic

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The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene

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