Position effects on eukaryotic gene expression
Integrity signals
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Translational and/or post-translational processes might also be rate-limiting for protein production, because of the lack of correlation between gene copy number and the amount of secreted proteins.
“It has been suggested that translational and/or post-translational processes might also be rate-limiting for protein production, because of the lack of correlation between gene copy number and the amount of secreted proteins (Wilson et al., 1990;Mohan et al., 2008).”
From Therapeutic glycoprotein production in mammalian cells (2017) · cites this paper as Wilson et al., 1990
Cites
Temporal control of puffing activity in polytene chromosomes
Ashburner, M., Chihara, C., Meltzer, P., & Richards, G. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.038.01.070 · Cited by 641 · see citing works
Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C., & Kornberg, T. (1987) · Genes & Development · doi:10.1101/gad.1.1.19 · Cited by 153 · see citing works
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Refinement of Tools for Targeted Gene Expression in Drosophila
Pfeiffer, B. D., Ngo, T.-T. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010) · Genetics · doi:10.1534/genetics.110.119917 · Cited by 1,153 · see citing works
Chung, J. H., Whiteley, M., & Felsenfeld, G. (1993) · Cell · doi:10.1016/0092-8674(93)80052-g · Cited by 854 · see citing works
Deans, C., & Maggert, K. A. (2015) · Genetics · doi:10.1534/genetics.114.173492 · Cited by 554 · see citing works
Yang, X. W., Model, P., & Heintz, N. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-859 · Cited by 544 · see citing works
Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription
Milot, E., Strouboulis, J., Trimborn, T., Wijgerde, M., de Boer, E., Langeveld, A., Tan-Un, K., Vergeer, W., Yannoutsos, N., Grosveld, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81327-6 · Cited by 314 · see citing works
Therapeutic glycoprotein production in mammalian cells
Lalonde, M.-E., & Durocher, Y. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.04.028 · Cited by 296 · see citing works
Guidelines to cell engineering for monoclonal antibody production
Rita Costa, A., Elisa Rodrigues, M., Henriques, M., Azeredo, J., & Oliveira, R. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.10.002 · Cited by 178 · see citing works
Young, 3., & Gainer, H. (2003) · Neuroendocrinology · doi:10.1159/000073702 · Cited by 103 · see citing works
- Authors
- Wilson, C., Bellen, H. J., & Gehring, W. J.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1990-11
- Volume
- 6
- Issue
- 1
- Pages
- 679-714
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W2101287056
- Cited by
- 379
- References
- 2
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 11 · 2017: 11 · 2016: 11 · 2015: 19 · 2014: 11 · 2013: 14 · 2012: 11
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- position effect, eukaryotic gene expression, gene expression regulation, chromatin, transcriptional repression, cis-regulatory elements
- MeSH terms
- Animals, Chromosome Mapping, Chromosomes, Enhancer Elements, Genetic, Gene Expression Regulation, Humans, Regulatory Sequences, Nucleic Acid, Gene Rearrangement, Animals, Genetically Modified
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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