PreprintCited by 581DNA Repair MechanismsGenetic factors in colorectal cancerFungal and yeast genetics research

The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair

Open access

Marsischky, G T, Filosi, N, Kane, M F, Kolodner, R·1996·Genes & Development

Open this paper in CoChat — free account Open PDF

Abstract

Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study the role of MSH2, MSH3, and MSH6 in mismatch repair has been examined by measuring the rate of accumulating mutations and mutation spectrum in strains containing different combinations of msh2, msh3, and msh6 mutations and by studying the physical interaction between the MSH2 protein and the MSH3 and MSH6 proteins. The results indicate that S. cerevisiae has two pathways of MSH2-dependent mismatch repair: one that recognized single-base mispairs and requires MSH2 and MSH6, and a second that recognizes insertion/deletion mispairs and requires a combination of either MSH2 and MSH6 or MSH2 and MSH3. The redundancy of MSH3 and MSH6 explains the greater prevalence of hmsh2 mutations in HNPCC families and suggests how the role of hmsh3 and hmsh6 mutations in cancer susceptibility could be analyzed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.10.4.407

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,884
Self-citation
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
Ionov, Y., Peinado, M. A., Malkhosyan, S. R., Shibata, D. K., & Perucho, M. (1993) · Nature · doi:10.1038/363558a0 · Cited by 2,691
Clues to the Pathogenesis of Familial Colorectal Cancer
Aaltonen, L. A., Peltomäki, P., Leach, F. S., Sistonen, P., Pylkkänen, L., Mecklin, J., Järvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., et al. (1993) · Science · doi:10.1126/science.8484121 · Cited by 2,683
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050
Self-citation
Mutation of a mutL Homolog in Hereditary Colon Cancer
Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,822
Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer
Nicolaides, N. C., Papadopoulos, N., Liu, B., Weit, Y.-F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., et al. (1994) · Nature · doi:10.1038/371075a0 · Cited by 1,543
The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
Strand, M. K., Prolla, T. A., Liskay, R. M., & Petes, T. D. (1993) · Nature · doi:10.1038/365274a0 · Cited by 1,090
Hypermutability and mismatch repair deficiency in RER+ tumor cells
Parsons, R. E., Li, G., Longley, M. J., Fang, W.-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., & Modrich, P. L. (1993) · Cell · doi:10.1016/0092-8674(93)90331-j · Cited by 1,054

Flagged first, then by citations

Show all 58 references

1 of the 58 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

1994, Mismatch repair proteins directly affect gene conversion in Saccharomyces cerevisiae by regulating heteroduplex tract length., Genetics, 137, 19
1995, Structure of the human MLH1 locus and analysis of HNPCC kindreds for mlhl mutations., Cancel Res., 55, 242
Sherman, F., G.R. Fink, and J.B. Hicks. 1986. Yeast DNA isolations. In Methods in yeast genetics, pp. 125–134. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Sorted by citations

Items 201–300 of 574

Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops
Lang, W. H., Coats, J. E., Majka, J., Hura, G. L., Lin, Y., Rasnik, I., & McMurray, C. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105461108 · Cited by 67
Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability.
Ikeda, M., Orimo, H., Moriyama, H., Nakajima, E., Matsubara, N., Mibu, R., Tanaka, N., Shimada, T., Kimura, A., & Shimizu, K. (1998) · PubMed · Cited by 67
Isolation and Characterization of New Proliferating Cell Nuclear Antigen ( POL30 ) Mutator Mutants That Are Defective in DNA Mismatch Repair
Lau, P. J., Flores‐Rozas, H., & Kolodner, R. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6669-6680.2002 · Cited by 66
Self-citation
Significance ofautocrine motility factor receptor gene expression as a prognostic factor in non-small-cell lung cancer
Takanami, I., Takeuchi, K., Watanabe, H., Yanagawa, T., Takagishi, K., & Raz, A. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(20011120)95:6 · Cited by 13
Identification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage
Xie, Y., Liu, Y., Argueso, J. L., Henricksen, L. A., Kao, H.-I., Bambara, R. A., & Alani, E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.4889-4899.2001 · Cited by 67
Novel dominant mutations in Saccharomyces cerevisiae MSH6
Gupta, R. D., & Kolodner, R. D. (2000) · Nature Genetics · doi:10.1038/71684 · Cited by 66
Self-citation
Microsatellite Instability Phenotype of Tumors: Genotyping or Immunohistochemistry? The Jury Is Still Out
de la Chapelle, A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.4.897 · Cited by 66
Strand discrimination in DNA mismatch repair
Putnam, C. D. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103161 · Cited by 65
EXO1 and MSH6 Are High-Copy Suppressors of Conditional Mutations in the MSH2 Mismatch Repair Gene of Saccharomyces cerevisiae
Sokolsky, T. D., & Alani, E. (2000) · Genetics · doi:10.1093/genetics/155.2.589 · Cited by 65
Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity
Degtyareva, N. P., Greenwell, P. W., Hofmann, E. R., Hengartner, M. O., Zhang, L., Culotti, J. G., & Petes, T. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032671599 · Cited by 67
Interaction between the Msh2 and Msh6 Nucleotide-binding Sites in the Saccharomyces cerevisiae Msh2-Msh6 Complex
Hargreaves, V. V., Shell, S. S., Mazur, D. J., Heß, M., & Kolodner, R. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096388 · Cited by 64
Self-citation
Dominant Saccharomyces cerevisiae msh6 Mutations Cause Increased Mispair Binding and Decreased Dissociation from Mispairs by Msh2-Msh6 in the Presence of ATP
Heß, M., Gupta, R. D., & Kolodner, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202282200 · Cited by 64
Self-citation
Frameshift mutation, microsatellites and mismatch repair
Strauss, B. S. (1999) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(99)00066-6 · Cited by 66
Identification of a Second MutL DNA Mismatch Repair Complex (hPMS1 and hMLH1) in Human Epithelial Cells
Leung, W. K., Kim, J. J., Wu, L., Sepulveda, J. L., & Sepulveda, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908768199 · Cited by 64
Sensitivity to Phosphonoacetic Acid
Li, L., Murphy, K. M., Kanevets, U., & Reha-Krantz, L. J. (2005) · Genetics · doi:10.1534/genetics.104.040295 · Cited by 63
'Saccharomyces cerevisiae MSH2/6 Complex Interacts with Holliday Junctions and Facilitates Their Cleavage by Phage Resolution Enzymes
Marsischky, G., Lee, S., Griffith, J. D., & Kolodner, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7200 · Cited by 63
Self-citation
Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
Zaanan, A., Meunier, K., Sangar, F., Fléjou, J., & Praz, F. (2011) · Cellular Oncology · doi:10.1007/s13402-011-0024-x · Cited by 66
Adaptive Mutation inSaccharomyces cerevisiae
Heidenreich, E. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701507773 · Cited by 62
Small Slipped Register Genetic Instabilities in Escherichia coli in Triplet Repeat Sequences Associated with Hereditary Neurological Diseases
Wells, R. D., Parniewski, P., Pluciennik, A., Bacolla, A., Gellibolian, R., & Jaworski, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19532 · Cited by 62
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
Mertz, T. M., Sharma, S., Chabes, A., & Shcherbakova, P. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422934112 · Cited by 62
Regulation of the Human MSH6 Gene by the Sp1 Transcription Factor and Alteration of Promoter Activity and Expression by Polymorphisms
Gazzoli, I., & Kolodner, R. D. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7992-8007.2003 · Cited by 61
Self-citation
Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway
Smith, C. E., Mendillo, M. L., Bowen, N., Hombauer, H., Campbell, C. S., Desai, A. B., Putnam, C. D., & Kolodner, R. D. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003869 · Cited by 60
Self-citation
Sequence Composition and Context Effects on the Generation and Repair of Frameshift Intermediates in Mononucleotide Runs in Saccharomyces cerevisiae
Harfe, B. D., & Jinks-Robertson, S. (2000) · Genetics · doi:10.1093/genetics/156.2.571 · Cited by 61
Cloning and Characterization of the Human andCaenorhabditis elegansHomologs of theSaccharomyces cerevisiae MSH5Gene
Winand, N. J., Panzer, J. A., & Kolodner, R. D. (1998) · Genomics · doi:10.1006/geno.1998.5447 · Cited by 60
Self-citation
Microsatellite Instability and DNA Mismatch Repair Deficiency Testing in Hereditary and Sporadic Gastrointestinal Cancers
Gologan, A., & Sepulveda, A. R. (2005) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.12.001 · Cited by 59
Functional analysis of human MutS and MutS complexes in yeast
Clark, A., Cook, M. E., Tran, H. T., Gordenin, D. A., Resnick, M. A., & Kunkel, T. A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.3.736 · Cited by 59
DNA mismatch repair and cancer
Prolla, T. A. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80005-7 · Cited by 59
Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ɛ
Clark, A., Lujan, S. A., Kissling, G. E., & Kunkel, T. A. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.02.001 · Cited by 58
Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes
Ou, J., Niessen, R. C., Lützen, A., Sijmons, R. H., Kleibeuker, J. H., de Wind, N., Rasmussen, L. J., & Hofstra, R. M. W. (2007) · Human Mutation · doi:10.1002/humu.20580 · Cited by 58
Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins
Bowen, N., Smith, C. E., Srivatsan, A., Willcox, S., Griffith, J. D., & Kolodner, R. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318971110 · Cited by 58
Self-citation
The immunogenicity of colorectal cancers with high-degree microsatellite instability
Banerjea, A., Bustin, S. A., & Dorudi, S. (2005) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-3-26 · Cited by 59
Mutation Rates, Spectra and Hotspots in Mismatch Repair-Deficient Caenorhabditis elegansSequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession nos. AY863110, AY863111, AY863112, AY863113, AY863114, AY863115, AY863116, AY863117, AY863118, AY863119, AY863120, AY863121, AY863122, AY863123, AY863124, AY863125, AY863126, AY863127, AY863128, AY863129, AY863130, AY863131, AY863132, AY863133, AY863134, AY863135, AY863136, AY863137, AY863138, AY863139, AY863140, AY863141, AY863142, AY863143.
Denver, D. R., Feinberg, S., Estes, S., Thomas, W. K., & Lynch, M. (2005) · Genetics · doi:10.1534/genetics.104.038521 · Cited by 56
Cloning, Structural Characterization, and Chromosomal Localization of the Human Orthologue ofSaccharomyces cerevisiaeMSH5 Gene
Her, C., & Doggett, N. A. (1998) · Genomics · doi:10.1006/geno.1998.5374 · Cited by 56
Concerted Action of Exonuclease and Gap-dependent Endonuclease Activities of FEN-1 Contributes to the Resolution of Triplet Repeat Sequences (CTG) - and (GAA) -derived Secondary Structures Formed during Maturation of Okazaki Fragments
Singh, P., Zheng, L., Chavez, V., Qiu, J., & Shen, B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606582200 · Cited by 55
TaMSH7: A cereal mismatch repair gene that affects fertility in transgenic barley (Hordeum vulgare L.)
Lloyd, A. H., Milligan, A. S., Langridge, P., & Able, J. A. (2007) · BMC Plant Biology · doi:10.1186/1471-2229-7-67 · Cited by 55
Removal of Frameshift Intermediates by Mismatch Repair Proteins in Saccharomyces cerevisiae
Harfe, B. D., & Jinks-Robertson, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4766 · Cited by 56
Separation-of-Function Mutations in Saccharomyces cerevisiae MSH2 That Confer Mismatch Repair Defects but Do Not Affect Nonhomologous-Tail Removal during Recombination
Studamire, B., Price, G. M., Sugawara, N., Haber, J. E., & Alani, E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7558 · Cited by 55
Analysis of the Binding of p53 to DNAs Containing Mismatched and Bulged Bases
Degtyareva, N. P., Subramanian, D., & Griffith, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006795200 · Cited by 55
Large-scale phenotypic analysis—the pilot project on yeast chromosome III
Rieger, K.-J., Kaniak, A., Coppée, J., Aljinovic, G., Baudin‐Baillieu, A., Orlowska, G., Gromadka, R., Groudinsky, O., di Rago, J., & Słonimski, P. P. (1997) · Yeast · doi:10.1002/(sici)1097-0061(199712)13:16 · Cited by 55
Frequent Germline Mutations and Somatic Repeat Instability in DNA Mismatch-Repair-Deficient Caenorhabditis elegans
Tijsterman, M., Pothof, J., & Plasterk, R. H. A. (2002) · Genetics · doi:10.1093/genetics/161.2.651 · Cited by 54
A DNA mismatch repair gene links to thePh2locus in wheat
Dong, C., Whitford, R., & Langridge, P. (2002) · Genome · doi:10.1139/g01-126 · Cited by 54
MSH6 germline mutations are rare in colorectal cancer families
Peterlongo, P., Nafa, K., Lerman, G. S., Glogowski, E., Shia, J., Ye, T. Z., Markowitz, A. J., Guillem, J. G., Kolachana, P., Boyd, J. A., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11415 · Cited by 53
Saccharomyces cerevisiae MSH2–MSH3 and MSH2–MSH6 Complexes Display Distinct Requirements for DNA Binding Domain I in Mismatch Recognition
Lee, S. D., Surtees, J. A., & Alani, E. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.099 · Cited by 52
Dual recognition–incision enzymes might be involved in mismatch repair and meiosis
Malik, H. S., & Henikoff, S. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01623-6 · Cited by 52
A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability
Kadyrova, L. Y., Mertz, T. M., Zhang, Y., Northam, M. R., Sheng, Z., Lobachev, K. S., Shcherbakova, P. V., & Kadyrov, F. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003899 · Cited by 53
The instability within: problems in current analyses of microsatellite instability
Maehara, Y., Oda, S., & Sugimachi, K. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00061-6 · Cited by 51
DNA Replication Error-Induced Extinction of Diploid Yeast
Herr, A. J., Kennedy, S. R., Knowels, G. M., Schultz, E. M., & Preston, B. D. (2014) · Genetics · doi:10.1534/genetics.113.160960 · Cited by 50
Simple Detection of Germline Microsatellite Instability for Diagnosis of Constitutional Mismatch Repair Cancer Syndrome
Ingham, D., Diggle, C. P., Berry, I. R., Bristow, C. A., Hayward, B. E., Rahman, N., Markham, A. F., Sheridan, E. G., Bonthron, D. T., & Carr, I. (2013) · Human Mutation · doi:10.1002/humu.22311 · Cited by 49
Mispair-specific Recruitment of the Mlh1-Pms1 Complex Identifies Repair Substrates of the Saccharomyces cerevisiae Msh2-Msh3 Complex
Srivatsan, A., Bowen, N., & Kolodner, R. D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.552190 · Cited by 48
Self-citation
Mlh2 Is an Accessory Factor for DNA Mismatch Repair in Saccharomyces cerevisiae
Campbell, C. S., Hombauer, H., Srivatsan, A., Bowen, N., Gries, K., Desai, A. B., Putnam, C. D., & Kolodner, R. D. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004327 · Cited by 48
Self-citation
Mutator effects of overproducing DNA polymerase η (Rad30) and its catalytically inactive variant in yeast
Pavlov, Y. I., Nguyen, D., & Kunkel, T. A. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00131-2 · Cited by 50
Bcl2 Impedes DNA Mismatch Repair by Directly Regulating the hMSH2-hMSH6 Heterodimeric Complex
Hou, Y., Gao, F., Wang, Q., Zhao, J., Flagg, T. O., Zhang, Y., & Deng, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608523200 · Cited by 48
The msh2 Gene of Schizosaccharomyces pombe Is Involved in Mismatch Repair, Mating-Type Switching, and Meiotic Chromosome Organization
Rudolph, C., Kunz, C., Parisi, S., Lehmann, E., Hartsuiker, E., Fartmann, B., Kramer, W., Kohli, J., & Fleck, O. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.241 · Cited by 48
A Saccharomyces cerevisiae RNase H2 Interaction Network Functions To Suppress Genome Instability
Allen, S., Martinez, S. L., Putnam, C. D., & Kolodner, R. D. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00960-13 · Cited by 48
Self-citation
Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival
Drotschmann, K., Topping, R. P., Clodfelter, J. E., & Salsbury, F. R. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.02.011 · Cited by 47
DNA REPAIR AND COLORECTAL CANCER
Marra, G., & Boland, C. R. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70273-9 · Cited by 47
Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast
Williams, L. N., Herr, A. J., & Preston, B. D. (2013) · Genetics · doi:10.1534/genetics.112.146910 · Cited by 48
A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair
Kolodner, R. D. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.11.009 · Cited by 46
Self-citation
Single-molecule views of MutS on mismatched DNA
Lee, J., Cho, W., Park, J., Jeon, Y., Kim, D., Lee, S. H., & Fishel, R. A. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.014 · Cited by 44
Spontaneous Frameshift Mutations in Saccharomyces cerevisiae: Accumulation During DNA Replication and Removal by Proofreading and Mismatch Repair Activities
Greene, C. N., & Jinks-Robertson, S. (2001) · Genetics · doi:10.1093/genetics/159.1.65 · Cited by 45
Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions
Martinez, S. L., & Kolodner, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000798107 · Cited by 44
Self-citation
GENETIC LOAD OF THE YEASTSACCHAROMYCES CEREVISIAEUNDER DIVERSE ENVIRONMENTAL CONDITIONS
Korona, R. (1999) · Evolution · doi:10.1111/j.1558-5646.1999.tb04577.x · Cited by 44
Mismatch Repair Blocks Expansions of Interrupted Trinucleotide Repeats in Yeast
Rolfsmeier, M. L., Dixon, M. J., & Lahue, R. S. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00146-5 · Cited by 44
Frequent Somatic Mutations ofhMSH3with Reference to Microsatellite Instability in Hereditary Nonpolyposis Colorectal Cancers
Akiyama, Y., Tsubouchi, N., & Yuasa, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6942 · Cited by 44
Oligonucleotide transformation of yeast reveals mismatch repair complexes to be differentially active on DNA replication strands
Kow, Y. W., Bao, G., Reeves, J., Jinks-Robertson, S., & Crouse, G. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704695104 · Cited by 43
Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain
Ellison, A. R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh855 · Cited by 45
Probing DNA- and ATP-mediated Conformational Changes in the MutS Family of Mispair Recognition Proteins Using Deuterium Exchange Mass Spectrometry
Mendillo, M. L., Putnam, C. D., Mo, A. O., Jamison, J. W., Li, S., Woods, V. L., & Kolodner, R. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108894 · Cited by 42
Self-citation
Do MSH6 mutations contribute to double primary cancers of the colorectum and endometrium?
Charames, G. S., Millar, A., Pal, T., Narod, S. A., & Bapat, B. V. (2000) · Human Genetics · doi:10.1007/s004390000417 · Cited by 42
Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: A population‐based study in northern Sweden
Cederquist, K., Emanuelsson, M., Göransson, I., Holinski‐Feder, E., Müller-Koch, Y., Golovleva, I., & Grönberg, H. (2004) · International Journal of Cancer · doi:10.1002/ijc.11718 · Cited by 41
Unpredictable Fitness Transitions Between Haploid and Diploid Strains of the Genetically Loaded Yeast Saccharomyces cerevisiae
Korona, R. (1999) · Genetics · doi:10.1093/genetics/151.1.77 · Cited by 41
Tumor-associated Apc mutations in Mlh1−/−Apc1638N mice reveal a mutational signature of Mlh1 deficiency
Kuraguchi, M., Edelmann, W., Yang, K., Lipkin, M., Kucherlapati, R., & Brown, A. M. C. (2000) · Oncogene · doi:10.1038/sj.onc.1203962 · Cited by 41
Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins
Shell, S. S., Putnam, C. D., & Kolodner, R. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704148104 · Cited by 40
Self-citation
Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae
Enserink, J. M., Hombauer, H., Huang, M., & Kolodner, R. D. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811083 · Cited by 40
Self-citation
The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor α
Wada‐Hiraike, O., Yano, T., Nei, T., Matsumoto, Y., Nagasaka, K., Takizawa, S., Oishi, H., Arimoto, T., Nakagawa, S., Yasugi, T., et al. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602614 · Cited by 39
Role of Mismatch Repair in the Fidelity of RAD51 - and RAD59 -Dependent Recombination in Saccharomyces cerevisiae
Spell, R. M., & Jinks-Robertson, S. (2003) · Genetics · doi:10.1093/genetics/165.4.1733 · Cited by 41
Isolation and Characterization of Point Mutations in Mismatch Repair Genes That Destabilize Microsatellites in Yeast
Sia, E. A., Dominska, M., Stefanovic, L., & Petes, T. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.23.8157-8167.2001 · Cited by 40
Hereditary Factors in Gynecologic Cancer
Lynch, H. T., Casey, M. J., Shaw, T. G., & Lynch, J. F. (1998) · The Oncologist · doi:10.1634/theoncologist.3-5-319 · Cited by 39
Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair
Ciotta, C., Ceccotti, S., Aquilina, G., Humbert, O., Palombo, F., Jiricny, J., & Bignami, M. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1559 · Cited by 39
Functional Studies and Homology Modeling of Msh2-Msh3 Predict that Mispair Recognition Involves DNA Bending and Strand Separation
Dowen, J. M., Putnam, C. D., & Kolodner, R. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01558-09 · Cited by 38
Self-citation
Analysis of Conditional Mutations in the Saccharomyces cerevisiae MLH1 Gene in Mismatch Repair and in Meiotic Crossing Over
Argueso, J. L., Smith, D. L., Yi, J., Waase, M., Sarin, S., & Alani, E. (2002) · Genetics · doi:10.1093/genetics/160.3.909 · Cited by 38
THE EFFECTS OF SEX AND MUTATION RATE ON ADAPTATION IN TEST TUBES AND TO MOUSE HOSTS BY SACCHAROMYCES CEREVISIAE
Grimberg, B. T., & Zeyl, C. (2005) · Evolution · doi:10.1111/j.0014-3820.2005.tb01001.x · Cited by 37
Mutator dynamics in sexual and asexual experimental populations of yeast
Raynes, Y., Gazzara, M. R., & Sniegowski, P. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-158 · Cited by 36
Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1.
Her, C., Wu, X., Griswold, M. D., & Zhou, F. (2003) · PubMed · Cited by 36
Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
Smith, C. E., Bowen, N., Graham, W. J., Goellner, E. M., Srivatsan, A., & Kolodner, R. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662189 · Cited by 35
Self-citation
MSH2-deficient human cells exhibit a defect in the accurate termination of homology-directed repair of DNA double-strand breaks.
Villemure, J.-F., Abaji, C., Cousineau, I., & Belmaaza, A. (2003) · PubMed · Cited by 35
RER phenotype and its associated mutations in familial gastric cancer
Shinmura, K. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.247 · Cited by 35
Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1Preprint
Terui, R., Nagao, K., Kawasoe, Y., Taki, K., Higashi, T. L., Tanaka, S., Nakagawa, T., Obuse, C., Masukata, H., & Takahashi, T. S. (2018) · Genes & Development · doi:10.1101/gad.310995.117 · Cited by 35
Neoadjuvant therapy in microsatellite-stable colorectal carcinoma induces concomitant loss of MSH6 and Ki-67 expression
Kuan, S., Ren, B., Brand, R. E., Dudley, B., & Pai, R. K. (2017) · Human Pathology · doi:10.1016/j.humpath.2017.02.003 · Cited by 34
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome
Raskin, L., Schwenter, F., Freytsis, M., Tischkowitz, M. D., Wong, N., Chong, G., Narod, S., Levine, D. A., Bogomolniy, F., Aronson, M. D., et al. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01594.x · Cited by 34
The influence of the mismatch-repair system on stationary-phase mutagenesis in the yeast Saccharomyces cerevisiae
Hałas, A., Baranowska, H., & Policińska, Z. (2002) · Current Genetics · doi:10.1007/s00294-002-0334-7 · Cited by 34
From bacteria to plants: A compendium of mismatch repair assays
Spampinato, C. P., Gómez, R., Galles, C., & Lario, L. D. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.07.001 · Cited by 34
Different genetic pathways in the development of periocular sebaceous gland carcinomas in presumptive Muir-Torre syndrome patients
Goldberg, M., Rummelt, C., Foja, S., Holbach, L., & Ballhausen, W. G. (2006) · Human Mutation · doi:10.1002/humu.20281 · Cited by 34
Association of Mismatch Repair Deficiency With PTEN Frameshift Mutations in Endometrial Cancers and the Precursors in a Japanese Population
Kanaya, T., Kyo, S., Sakaguchi, J., Maida, Y., Nakamura, M., Takakura, M., Hashimoto, M., Mizumoto, Y., & Inoue, M. (2005) · American Journal of Clinical Pathology · doi:10.1309/paac-lg8d-xdk0-x2b1 · Cited by 34
Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis
Schmidt, T. T., Reyes, G. X., Gries, K., Ceylan, C. Ü., Sharma, S., Meurer, M., Knop, M., Chabes, A., & Hombauer, H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618714114 · Cited by 33
Tracing Cell Fates in Human Colorectal Tumors from Somatic Microsatellite Mutations
Tsao, J., Zhang, J., Salovaara, R., Li, Z.-H., Järvinen, H., Mecklin, J., Aaltonen, L. A., & Shibata, D. K. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65663-5 · Cited by 33
Evidence for a direct association of hMRE11 with the human mismatch repair protein hMLH1
Her, C. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00079-4 · Cited by 33
Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway
Chen, Z., Tran, M. K., Tang, M., Wang, W., Gong, Z., & Chen, J. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.056093 · Cited by 33
The Yeast HSM3 Gene Acts in One of the Mismatch Repair Pathways
Федорова, И. В., Gracheva, L. M., Kovaltzova, S. V., Evstuhina, T. A., Alekseev, S., & Королев, В. Г. (1998) · Genetics · doi:10.1093/genetics/148.3.963 · Cited by 33
Absence of PTEN Repeat Tract Mutation in Endometrial Cancers with Microsatellite Instability
Cohn, D. E., Basil, J., Venegoni, A. R., Mutch, D. G., Rader, J. S., Herzog, T. J., Gersell, D. J., & Goodfellow, P. J. (2000) · Gynecologic Oncology · doi:10.1006/gyno.2000.5900 · Cited by 33
Characterization of Distinct Human Endometrial Carcinoma Cell Lines Deficient in Mismatch Repair That Originated from a Single Tumor
Glaab, W. E., Risinger, J. I., Umar, A., Kunkel, T. A., Barrett, J. C., & Tindall, K. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26662 · Cited by 33

Authors: Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R.
Affiliations: Dana-Farber Cancer Institute (US)
ORCID: Marsischky, G T
Kolodner, R
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1996-02-15
Volume: 10
Issue: 4
Pages: 407-420
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.10.4.407
OpenAlex: W2170472485
Cited by: 581
References: 58
Citations by year: 2026: 7 · 2025: 3 · 2024: 5 · 2023: 14 · 2022: 12 · 2021: 16 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 14 · 2016: 6 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 9
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (CA06516)
National Cancer Institute (CA06516, P30CA006516)
National Institute of General Medical Sciences (GM50006, R01GM050006)
National Institute of Allergy and Infectious Diseases (AI28691, P30AI028691)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: DNA mismatch repair, MSH2, MSH3, MSH6, MSH1, Saccharomyces cerevisiae, protein-protein interaction, mutation spectrum, mutation rate, Lynch syndrome, cancer susceptibility, MutS homologs
MeSH terms: MutS Homolog 3 Protein, Adenosine Triphosphatases, Alleles, Amino Acid Sequence, Bacterial Proteins, Base Sequence, DNA Repair, DNA-Binding Proteins, DNA, Fungal, Electrophoresis, Polyacrylamide Gel, Fungal Proteins, Genes, Fungal, Models, Genetic, Molecular Sequence Data, Phenotype, Phylogeny, Precipitin Tests, Saccharomyces cerevisiae, Databases, Factual, Sequence Alignment, Point Mutation, Sequence Homology, Amino Acid, Sequence Analysis, DNA Primers, Saccharomyces cerevisiae Proteins, Escherichia coli Proteins, MutS Homolog 2 Protein, MutS DNA Mismatch-Binding Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks