PreprintCited by 581DNA Repair MechanismsGenetic factors in colorectal cancerFungal and yeast genetics research

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Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair

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Marsischky, G T, Filosi, N, Kane, M F, Kolodner, R·1996·Genes & Development

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Abstract

Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study the role of MSH2, MSH3, and MSH6 in mismatch repair has been examined by measuring the rate of accumulating mutations and mutation spectrum in strains containing different combinations of msh2, msh3, and msh6 mutations and by studying the physical interaction between the MSH2 protein and the MSH3 and MSH6 proteins. The results indicate that S. cerevisiae has two pathways of MSH2-dependent mismatch repair: one that recognized single-base mispairs and requires MSH2 and MSH6, and a second that recognizes insertion/deletion mispairs and requires a combination of either MSH2 and MSH6 or MSH2 and MSH3. The redundancy of MSH3 and MSH6 explains the greater prevalence of hmsh2 mutations in HNPCC families and suggests how the role of hmsh3 and hmsh6 mutations in cancer susceptibility could be analyzed.

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Self-citation
The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.
Kuraguchi, M., Yang, K., Wong, E., Avdievich, E., Fan, K., Kolodner, R. D., Lipkin, M., Brown, A. M. C., Kucherlapati, R., & Edelmann, W. (2001) · PubMed · Cited by 72
Self-citation
Endonuclease activities of MutLα and its homologs in DNA mismatch repair
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Authors: Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R.
Affiliations: Dana-Farber Cancer Institute (US)
ORCID: Marsischky, G T
Kolodner, R
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1996-02-15
Volume: 10
Issue: 4
Pages: 407-420
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.10.4.407
OpenAlex: W2170472485
Cited by: 581
References: 58
Citations by year: 2026: 7 · 2025: 3 · 2024: 5 · 2023: 14 · 2022: 12 · 2021: 16 · 2020: 7 · 2019: 11 · 2018: 5 · 2017: 14 · 2016: 6 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 9
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (CA06516)
National Cancer Institute (CA06516, P30CA006516)
National Institute of General Medical Sciences (GM50006, R01GM050006)
National Institute of Allergy and Infectious Diseases (AI28691, P30AI028691)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: DNA mismatch repair, MSH2, MSH3, MSH6, MSH1, Saccharomyces cerevisiae, protein-protein interaction, mutation spectrum, mutation rate, Lynch syndrome, cancer susceptibility, MutS homologs
MeSH terms: MutS Homolog 3 Protein, Adenosine Triphosphatases, Alleles, Amino Acid Sequence, Bacterial Proteins, Base Sequence, DNA Repair, DNA-Binding Proteins, DNA, Fungal, Electrophoresis, Polyacrylamide Gel, Fungal Proteins, Genes, Fungal, Models, Genetic, Molecular Sequence Data, Phenotype, Phylogeny, Precipitin Tests, Saccharomyces cerevisiae, Databases, Factual, Sequence Alignment, Point Mutation, Sequence Homology, Amino Acid, Sequence Analysis, DNA Primers, Saccharomyces cerevisiae Proteins, Escherichia coli Proteins, MutS Homolog 2 Protein, MutS DNA Mismatch-Binding Protein

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Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair

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