The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
Open accessAbstract
Midline signaling by Hedgehog (Hh) family members has been implicated in patterning the vertebrate embryo. We have explored the potential regulatory role of cAMP-dependent protein kinase A (PKA) in these events. Zebrafish embryos injected with RNAs encoding Sonic hedgehog (Shh), Indian hedgehog (Ihh), or a dominant-negative regulatory subunit of PKA, PKI, have equivalent phenotypes. These include the expansion of proximal fates in the eye, ventral fates in the brain, and adaxial fates in somites and head mesenchyme. Moreover, ectopic expression of PKI partially rescues somite and optic stalk defects in no tail and cyclops mutants that lack midline structures that normally synthesize Shh. Conversely, all cell types promoted by ectopic expression of hhs and PKI are suppressed in embryos injected with RNA encoding a constitutively active catalytic subunit of PKA (PKA*). These results, together with epistasis studies on the block of ectopic Hh signaling by PKA*, indicate that PKA acts in target cells as a common negative regulator of Hedgehog signaling.
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Cites
Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
Self-citationInduction of dopaminergic neuron phenotype in the midbrain by sonic hedgehog protein
Wang, M. Z., Jin, P., Bumcrot, D. A., Marigo, V., Mcmahon, A. P., Wang, E. A., Woolf, T., & Pang, K. (1995) · Nature Medicine · doi:10.1038/nm1195-1184 · Cited by 158
Cited by
A Family of cAMP-Binding Proteins That Directly Activate Rap1
Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E., & Graybiel, A. M. (1998) · Science · doi:10.1126/science.282.5397.2275 · Cited by 1,362
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C., & Muenke, M. (1996) · Nature Genetics · doi:10.1038/ng1196-357 · Cited by 1,152
Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Self-citationIdentification of separate slow and fast muscle precursor cells in vivo, prior to somite formation
Devoto, S. H., Melançon, E., Eisen, J. S., & Westerfield, M. (1996) · Development · doi:10.1242/dev.122.11.3371 · Cited by 666
Metadata
- Authors
- Hammerschmidt, M., Bitgood, M. J., & McMahon, A. P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1996-03-15
- Volume
- 10
- Issue
- 6
- Pages
- 647-658
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1999100324
- Cited by
- 352
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. https://app.cochat.ai/papers/10.1101/gad.10.6.647
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- Hammerschmidt, M., Bitgood, M. J., & McMahon, A. P. (1996). Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes & Development. https://doi.org/10.1101/gad.10.6.647
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