The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nodal activity in the node governs left-right asymmetry
Open accessAbstract
Nodal is expressed at the lateral edges of the mouse node, but its function in this “organizer” tissue remains unknown due to the early lethality of Nodal mutant embryos. Here we used a genetic strategy to selectively remove Nodal activity from the node. Embryos lacking Nodal in the node fail to initiate molecular asymmetry in the left lateral plate mesoderm and exhibit multiple left-right patterning defects. Nodal may also act as a short-range signal to establish a functional midline barrier. Our findings confirm that the mouse node is instrumental in initiating left-right axis specification and identify Nodal as the key morphogen regulating this process.
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Citations
Cites
Morphogenesis of the murine node and notochordal plate
Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K., & Schoenwolf, G. C. (1994) · Developmental Dynamics · doi:10.1002/aja.1002010309 · Cited by 338
Cited by
TGF-β Superfamily Signaling in Embryonic Development and Homeostasis
Wu, M. Y., & Hill, C. S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.012 · Cited by 746
Activin/nodal signalling in stem cells
Pauklin, S., & Vallier, L. (2015) · Development · doi:10.1242/dev.091769 · Cited by 195
Cilia, calcium and the basis of left-right asymmetry
Norris, D. P. (2012) · BMC Biology · doi:10.1186/1741-7007-10-102 · Cited by 73
Self-citation
Metadata
- Authors
- Brennan, J., Norris, D. P., & Robertson, E. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-09-15
- Volume
- 16
- Issue
- 18
- Pages
- 2339-2344
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2056824123
- Cited by
- 298
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Brennan, J., Norris, D. P., & Robertson, E. J. (2002). Nodal activity in the node governs left-right asymmetry. Genes & Development. https://doi.org/10.1101/gad.1016202
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
