Activin/nodal signalling in stem cells
Abstract
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human and murine Noggin exhibit high sequence homology and functional equivalence.
“Human and murine Noggin exhibit high sequence homology and functional equivalence (Holley and Ferguson, 1997; Pauklin and Vallier, 2015), with comparable pricing (recombinant human Noggin, €9.54/µg; recombinant murine Noggin, €10.93/µg, R&D Systems, Bio-Techne GmbH, Germany, pricing for 6 March 2026).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Pauklin and Vallier, 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442 · see citing works
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570 · see citing works
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816 · cited 2× · see citing works
“Following implantation, a gradient of Nodal signalling defines the proximal-distal axis, which in turn establishes the anterior-posterior axis of the developing embryo (Arnold and Robertson, 2009).”
BackgroundFunctional analysis of activins during mammalian development
Matzuk, M. M., Kumar, T. R., Vassalli, A., Bickenbach, J. R., Roop, D. R., Jaenisch, R., & Bradley, A. (1995) · Nature · doi:10.1038/374354a0 · Cited by 578 · see citing works
Yamazaki, S., Iwama, A., Takayanagi, S., Morita, Y., Eto, K., Ema, H., & Nakauchi, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601236 · Cited by 270 · see citing works
Evolution of the TGF-β Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi
Pang, K., Ryan, J. F., Baxevanis, A. D., & Martindale, M. Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024152 · Cited by 93 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Dunphy, K. A., Schneyer, A. L., Hagen, M. J. and Jerry, D. J. (2011). The role of activin in mammary gland development and oncogenesis. Journal of mammary gland biology and neoplasia 16, 117--126.
- Luisi, S., Florio, P., Reis, F. M. and Petraglia, F. (2001). Expression and secretion of activin A: possible physiological and clinical implications. European journal of endocrinology / European Federation of Endocrine Societies 145, 225--236.
Cited by
Sorted by citations
Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works
- Authors
- Pauklin, S., & Vallier, L.
- Affiliations
- Anne McLaren Laboratory For Regenerative Medicine, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, West Forvie Building, Robinson Way, University of Cambridge, Cambridge CB2 0SZ, UK
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-02-15
- Volume
- 142
- Issue
- 4
- Pages
- 607-619
- ISSN
- 1477-9129
- 0950-1991
- Cited by
- 183
- References
- 6
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
