The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
Open accessAbstract
c-Myc promotes cell growth and transformation by ill-defined mechanisms. c- myc −/− mice die by embryonic day 10.5 (E10.5) with defects in growth and in cardiac and neural development. Here we report that the lethality of c- myc −/− embryos is also associated with profound defects in vasculogenesis and primitive erythropoiesis. Furthermore, c- myc −/− embryonic stem (ES) and yolk sac cells are compromised in their differentiative and growth potential. These defects are intrinsic to c-Myc, and are in part associated with a requirement for c-Myc for the expression of vascular endothelial growth factor (VEGF), as VEGF can partially rescue these defects. However, c-Myc is also required for the proper expression of other angiogenic factors in ES and yolk sac cells, including angiopoietin-2, and the angiogenic inhibitors thrombospondin-1 and angiopoietin-1. Finally, c- myc −/− ES cells are dramatically impaired in their ability to form tumors in immune-compromised mice, and the small tumors that sometimes develop are poorly vascularized. Therefore, c-Myc function is also necessary for the angiogenic switch that is indispensable for the progression and metastasis of tumors. These findings support the model wherein c-Myc promotes cell growth and transformation, as well as vascular and hematopoietic development, by functioning as a master regulator of angiogenic factors.
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Citations
Cites
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Cited by
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
Phenotype molding of stromal cells in the lung tumor microenvironment
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Reflecting on 25 years with MYC
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Metadata
- Authors
- Baudino, T. A., McKay, C., Pendeville-Samain, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-10-01
- Volume
- 16
- Issue
- 19
- Pages
- 2530-2543
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2030816211
- Cited by
- 525
- References
- 55
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Baudino, T. A., McKay, C., Pendeville-Samain, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L. (2002). c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes & Development. https://doi.org/10.1101/gad.1024602
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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