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EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1
Open accessAbstract
The TGF-β signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-β signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-β signaling than anticipated previously.
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Cited by
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Lee, S.-J. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.012103.135836 · Cited by 819
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510
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de Caestecker, M. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.004 · Cited by 464
The left-right axis in the mouse: from origin to morphology
Shiratori, H., & Hamada, H. (2006) · Development · doi:10.1242/dev.02384 · Cited by 301
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Namwanje, M., & Brown, C. W. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021881 · Cited by 294
Metadata
- Authors
- Cheng, S. K., Olale, F., Bennett, J. T., Brivanlou, A. H., & Schier, A. F.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-01
- Volume
- 17
- Issue
- 1
- Pages
- 31-36
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2131037997
- Cited by
- 161
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Cheng, S. K., Olale, F., Bennett, J. T., Brivanlou, A. H., & Schier, A. F. (2003). EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1. Genes & Development. https://doi.org/10.1101/gad.1041203
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