The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi
Open accessAbstract
An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis in the germ line. Their sequence suggests a role in DNA repair and/or replication, in chromatin remodeling, or in cell cycle control; there are also many novel genes that are highly conserved from yeast to human. Because known mutator genes are causally involved in many hereditary and sporadic human cancers, it is likely that some of these new mutators are equally relevant in cancer etiology.
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Cites
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Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578
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Simmer, F., Moorman, C., van der Linden, A. M., Kuijk, E., van den Berghe, P. V. E., Kamath, R. S., Fraser, A. G., Ahringer, J., & Plasterk, R. H. A. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000012 · Cited by 638
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Liebler, D. C., & Guengerich, F. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1720 · Cited by 323
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
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Metadata
- Authors
- Pothof, J., van Haaften, G., Thijssen, K., Kamath, R. S., Fraser, A. G., Ahringer, J., Plasterk, R. H. A., & Tijsterman, M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-31
- Volume
- 17
- Issue
- 4
- Pages
- 443-448
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1984842319
- Cited by
- 212
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Pothof, J., van Haaften, G., Thijssen, K., Kamath, R. S., Fraser, A. G., Ahringer, J., Plasterk, R. H. A., & Tijsterman, M. (2003). Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes & Development. https://doi.org/10.1101/gad.1060703
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