The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
Open accessAbstract
The activity of the E2F transcription factor is controlled by physical association with the retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family members are thought to control different aspects of E2F activity, but it has been unclear what the respective functions of these proteins might be. To dissect the specific functions of pRB, p107, and p130 we have investigated how the expression of E2F-regulated genes is changed in cultures of primary cells lacking each of these family members. Whereas no changes were found in the expression of E2F-target genes in cells lacking either p107 or p130, deregulated expression of E2F targets was seen in cells lacking pRB and in cells lacking both p107 and p130. Surprisingly, the genes that were disregulated in these two settings were completely different. These findings show that pRB and p107/p130 indeed provide different functions in E2F regulation and identify target genes that are dependent on pRB family proteins for their normal expression.
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“Although previous studies hinted that RB family proteins can regulate different E2F targets (Hurford et al., 1997) and that loss of RB can ultimately lead to increased loading of replications complexes on chromatin (Srinivasan et al., 2007), the selectivity of RB towards repressing replication genes was not appreciated.”
From Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence (2010) · cites this paper as Hurford et al., 1997
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Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264
Requirement for a functional Rb-1 gene in murine development
Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
Johnson, D. G., Schwarz, J. K., Cress, W. D., & Nevins, J. R. (1993) · Nature · doi:10.1038/365349a0 · Cited by 943
DeGregori, J. V., Kowalik, T. F., & Nevins, J. R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4215 · Cited by 918
Cyclin-Dependent Regulation of G 1 in Mammalian Fibroblasts
Ohtsubo, M., & Roberts, J. M. (1993) · Science · doi:10.1126/science.8384376 · Cited by 767
Resnitzky, D., Gossen, M., Bujard, H., & Reed, S. I. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1669 · Cited by 664
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- Tabor, S. and K. Struhl. 1994. DNA-dependent DNA polymerases. In Current protocols in molecular biology (ed. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl], pp. 3.5.1–3.5.15. Wiley/Greene, New York, NY.
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Bagella, L. (2012) · InTech eBooks · doi:10.5772/32543
Immortalization of primary rodent cells by SV40
Darmon, A. J., & Jut, P. S. (2001) · Perspectives in medical virology · doi:10.1016/s0168-7069(01)05002-9
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Weaks, R. L. (2010) · Digital Commons-TMC (Texas Medical Center)
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Hauck, L., & von Harsdorf, R. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18932-6_9
Lovicu, F. J., & Robinson, M. L. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511529825.001
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Kwak, K., Bae, B. N., Kim, K. H., Kim, H. J., Kim, Y., Kim, H. Y., Park, K. M., & Han, S. (2003) · Journal of Breast Cancer · doi:10.4048/jkbcs.2003.6.3.155
Epigenetic Control in Cellular Senescence
Helmbold, H., Deppert, W., & Bohn, W. (2011) · Wiley eBooks · doi:10.1002/9781118005743.ch3
Regulation Of Mammalian Myb Gene Expression
Tavner, F. J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-2869-4_10
The Regulation of Satellite Cell Function and Myogenesis by Isoforms of C/EBPβ
Lee, H. (2015) · uO Research (University of Ottawa) · doi:10.20381/ruor-4173
The tip60 HAT-complex is recruited to chromatin by the transcription factors E2F and Myc
Taubert, S. (2003) · reroDoc Digital Library
(2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511529825.014
Les protéines de la famille pRb sont des intégrateurs des signaux antiprolifératifs
Fabbrizio, E., & Sardet, C. (2001) · médecine/sciences · doi:10.4267/10608/2057
Assembly and regulation of the DREAM complex
Felthousen, J. G. (2016) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/yt55-ny74
Control of Cardiomyocyte Proliferation by p53/MDM2-Regulated microRNAs
Stanley-Hasnain, S. (2016) · TSpace (University of Toronto)
The Role of the Retinoblastoma Protein Family in Skeletal Myogenesis
Ciavarra, G. (2011) · Library and Archives Canada (Government of Canada)
Changes in Protein Abundance are Essential for Proper Cell Cycle Regulation
Lane, K. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/ek0g-9846
Cell Cycle Regulatory Genes as Targets of Retinoids
Soprano, K. J., Zhang, S., Zhang, D., Holmes, W. F., Masciullo, V., Giordano, A., & Soprano, D. R. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-401-6_7
Cell cycle progression requires repression by Groucho during S-phase and its relief at G2-phasePreprint
Bar-Cohen, S., & Paroush, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.22.481413
Kaldis, P. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.3090956.2774054
Receptors, Signaling Pathways, Cell Cycle, and DNA Damage Repair
Cagle, P. T. (2008) · Molecular pathology library · doi:10.1007/978-0-387-72430-0_2
Mira, H., Díez del Corral, R., & Morales, A. V. (2020) · Frontiers research topics · doi:10.3389/978-2-88963-988-5
Coschi, C. H., Ishak, C. A., Gallo, D., Marshall, A. E., Talluri, S., Wang, J., Cecchini, M. J., Martens, A. L., Percy, V., Welch, I., et al. (2023) · doi:10.1158/2159-8290.22529598
Dai, T., Chen, S., Liu, W. T., Zhang, B., Wu, L., Zhang, Z., Zhang, Q., Li, X., Wang, F., Pan, Y., et al. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100833
Kivinen, L. (1999) · Työväentutkimus Vuosikirja
Retinoblastoma Protein in Growth Control and Differentiation
Stepanova, L., & Harper, J. W. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-230-2_6
Metadata
- Authors
- Hurford, R. K., Cobrinik, D., Lee, M. H., & Dyson, N.
- Affiliations
- Massachusetts General Hospital (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-06-01
- Volume
- 11
- Issue
- 11
- Pages
- 1447-1463
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2151812144
- Cited by
- 431
- References
- 85
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 11 · 2012: 7
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA64402, R01CA064402)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- retinoblastoma protein, p107, p130, E2F transcription factors, E2F target genes, gene expression regulation, cell cycle regulation, cell cycle-dependent transcription
- MeSH terms
- Animals, Carrier Proteins, Cell Cycle, Cells, Cultured, DNA-Binding Proteins, Embryo, Mammalian, Fibroblasts, Gene Expression Regulation, Nuclear Proteins, Phosphoproteins, Promoter Regions, Genetic, Protein Binding, Proteins, Transcription Factors, Transfection, Trans-Activators, Retinoblastoma Protein, Culture Media, Serum-Free, Genes, Reporter, Mice, Knockout, Cell Cycle Proteins, Transcription Factor DP1, E2F Transcription Factors, Retinoblastoma-Like Protein p130, Retinoblastoma-Like Protein p107, Mice, Retinoblastoma-Binding Protein 1
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