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Cited by 357

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog

Open access
Blagden, Chris S., Currie, Peter D., Ingham, Philip W., Hughes, Simon M.·1997·Genes & Development

Abstract

The patterning of vertebrate somitic muscle is regulated by signals from neighboring tissues. We examined the generation of slow and fast muscle in zebrafish embryos and show that Sonic hedgehog (Shh) secreted from the notochord can induce slow muscle from medial cells of the somite. Slow muscle derives from medial adaxial myoblasts that differentiate early, whereas fast muscle arises later from a separate myoblast pool. Mutant fish lacking shh expression fail to form slow muscle but do form fast muscle. Ectopic expression of shh,either in wild-type or mutant embryos, leads to ectopic slow muscle at the expense of fast. We suggest that Shh acts to induce myoblasts committed to slow muscle differentiation from uncommitted presomitic mesoderm.

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Crossref · 10.1101/gad.11.17.2163

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Metadata

Authors
Blagden, C. S., Currie, P. D., Ingham, P. W., & Hughes, S. M.
Venue
Genes & Development
Published
1997-09-01
Volume
11
Issue
17
Pages
2163-2175
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2134253526
Cited by
357
References
66
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. https://app.cochat.ai/papers/10.1101/gad.11.17.2163
The paper
Blagden, C. S., Currie, P. D., Ingham, P. W., & Hughes, S. M. (1997). Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes & Development. https://doi.org/10.1101/gad.11.17.2163

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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