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The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses

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Peng, Jinrong, Carol, Pierre, Richards, Donald E., King, Kathryn E., Cowling, Rachel J., Murphy, George P., Harberd, Nicholas P.·1997·Genes & Development
DOI 10.1101/gad.11.23.3194
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Abstract

The Arabidopsis gai mutant allele confers a reduction in gibberellin (GA) responsiveness. Here we report the molecular cloning of GAI and a closely related gene GRS. The predicted GAI (wild-type) and gai (mutant) proteins differ only by the deletion of a 17-amino-acid segment from within the amino-terminal region. GAI and GRS contain nuclear localization signals, a region of homology to a putative transcription factor, and motifs characteristic of transcriptional coactivators. Genetic analysis indicates that GAI is a repressor of GA responses, that GA can release this repression, and that gai is a mutant repressor that is relatively resistant to the effects of GA. Mutations at SPY and GAR2 suppress the gai phenotype, indicating the involvement of GAI, SPY, and GAR2 in a signaling pathway that regulates GA responses negatively. The existence of this pathway suggests that GA modulates plant growth through derepression rather than through simple stimulation.

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Metadata

Authors
Peng, J., Carol, P., Richards, D. E., King, K. E., Cowling, R. J., Murphy, G. P., & Harberd, N. P.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1997-12-01
Volume
11
Issue
23
Pages
3194-3205
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.11.23.3194
OpenAlex
W1978678736
Cited by
1,153
References
5
Type
posted content
Language
en
Open access
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