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Cited by 274

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.

Open access
Kaya, G, Rodriguez, I, Jorcano, J L, Vassalli, P, Stamenkovic, I·1997·Genes & Development
DOI 10.1101/gad.11.8.996
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Abstract

CD44 is a broadly distributed polymorphic glycoprotein that serves as the principal cell-surface receptor for hyaluronate. Although CD44-mediated cell interaction with hyaluronate has been implicated in a variety of physiologic events, including cell-cell and cell-substrate adhesion, cell migration, proliferation, and activation, as well as hyaluronate uptake and degradation, the biologic role of CD44 in vivo in various tissues remains to be determined. In the present work we have developed transgenic mice that express an antisense CD44 cDNA driven by the keratin-5 promoter. These mice lack detectable CD44 expression in skin keratinocytes and corneal epithelium and display abnormal hyaluronate accumulation in the superficial dermis and corneal stroma, distinct morphologic alterations of basal keratinocytes and cornea, and defective keratinocyte proliferation in response to mitogen and growth factors. These alterations are reflected by a decrease in skin elasticity, impaired local inflammatory response and tissue repair, delayed hair regrowth, and failure of the epidermis to undergo hyperplasia in response to carcinogen. Our observations indicate that two major functions of CD44 in skin are the regulation of keratinocyte proliferation in response to extracellular stimuli and the maintenance of local hyaluronate homeostasis.

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Metadata

Authors
Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P., & Stamenkovic, I.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1997-04-15
Volume
11
Issue
8
Pages
996-1007
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.11.8.996
OpenAlex
W1979458027
Cited by
274
References
37
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. https://app.cochat.ai/papers/10.1101/gad.11.8.996
The paper
Kaya, G., Rodriguez, I., Jorcano, J. L., Vassalli, P., & Stamenkovic, I. (1997). Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes & Development. https://doi.org/10.1101/gad.11.8.996

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.